Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jane E Bourke"'
Patient-specific tracheal deformation, predicted toxicant uptake and histopathology in lung fibrosis
Autor:
Rebecca Bascom, Minyoung Kim, Simon G. Royce, Zachary Bitzer, Shirin Borhan, Pauline H. Go, Rickhesvar P.M. Mahraj, Negar Rassaei, Mary Vogt, James S. Ultman, Jane E. Bourke, Ali Borhan
Publikováno v:
Hygiene and Environmental Health Advances, Vol 13, Iss , Pp 100117- (2025)
Background: Our simulations previously predicted focal areas of gaseous pollutant dose delivered to the airway mucosa of a patient with idiopathic pulmonary fibrosis (IPF). We hypothesize a relation between these dose predictions and clinically meani
Externí odkaz:
https://doaj.org/article/f630f81ded4e49a09de7f14cf454000d
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122069 (2015)
The bacterial endotoxin, lipopolysaccharide (LPS) has been associated with occupational airway diseases with asthma-like symptoms and in acute exacerbations of COPD. The direct and indirect effects of LPS on small airway reactivity have not been full
Externí odkaz:
https://doaj.org/article/ada20f28e2ff4b1aa7f89700013fa3f9
Autor:
Chantal Donovan, Simon G Royce, James Esposito, Jenny Tran, Zaridatul Aini Ibrahim, Mimi L K Tang, Simon Bailey, Jane E Bourke
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74101 (2013)
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study used a mouse model of chronic allergic airways disease to induce inflammation and remodelling and determine whether in vi
Externí odkaz:
https://doaj.org/article/1edfeed6c9024142b6e69aacf349720e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Precision cut lung slices (PCLS) have emerged as powerful experimental tools for respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary airway contractility have been extended to pulmonary arteries and for assessment of
Externí odkaz:
https://doaj.org/article/af5f52d2455c4d8d9e7749ed6f6a6164
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
SARS-CoV-2 infection causes a variety of physiological responses in the lung, and understanding how the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), and its proteolytic activator, transmembrane serine protease 2 (TMPRSS2
Externí odkaz:
https://doaj.org/article/609ed4e6a10842b2948bcb8feeeccfd1
Autor:
Cheng Xue Qin, Lauren T. May, Renming Li, Nga Cao, Sarah Rosli, Minh Deo, Amy E. Alexander, Duncan Horlock, Jane E. Bourke, Yuan H. Yang, Alastair G. Stewart, David M. Kaye, Xiao-Jun Du, Patrick M. Sexton, Arthur Christopoulos, Xiao-Ming Gao, Rebecca H. Ritchie
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
G Protein-Coupled Receptors (GPCRs) can adopt different conformations, each linked to distinct cellular outcomes. Here the authors show that compound 17b, a novel agonist of the GPCR family member FPR, robustly activates cardioprotective but not detr
Externí odkaz:
https://doaj.org/article/662689059cf2432b82994c3add7656fb
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d51ee629457ea7ee0aa4c25a79f52c3
https://doi.org/10.1165/rcmb.2021-0544oc
https://doi.org/10.1165/rcmb.2021-0544oc
Autor:
Jane E. Bourke, Jiayin Diao, Karen J. Gregory, Ben Capuano, Aaron DeBono, Katie Leach, Tracy M. Josephs
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] The CaSR is a class C G protein-coupled receptor (GPCR) that acts as a multimodal chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic target in hyperparathyroidism and has emerged as a putative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490e43c525fe6dc6f3ec03a60ec4e3cc
https://doi.org/10.1021/acsptsci.1c00046
https://doi.org/10.1021/acsptsci.1c00046
Publikováno v:
Airway cell biology and immunopathology.
1. Precision cut lung slices (PCLS) offer a unique integrated experimental platform for investigating both inflammatory and immune responses to viral infection. 2. This study aimed to develop a protocol for robust infection of PCLS ex vivo with influ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4ef24d672e66b19d2de65f798b4650e
https://doi.org/10.1183/13993003.congress-2021.pa3691
https://doi.org/10.1183/13993003.congress-2021.pa3691
Publikováno v:
Life Science Alliance
A novel mouse model of induced-usual interstitial pneumonia shows bimodal fibrosis with honeycombing, similar to chronic lung disease seen with idiopathic pulmonary fibrosis.
Idiopathic pulmonary fibrosis is pathologically represented by usual i
Idiopathic pulmonary fibrosis is pathologically represented by usual i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d86b1ef6c6c82783af77823237cc50
https://pubmed.ncbi.nlm.nih.gov/34728556
https://pubmed.ncbi.nlm.nih.gov/34728556