Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jane E, Sexton"'
Autor:
Ana P. Luiz, Federico Iseppon, James J. Cox, John N. Wood, Jing Zhao, Sonia Santana-Varela, Yury D. Bogdanov, Andrei L. Okorokov, Samuel J. Gossage, Larissa de Clauser, Shengnan Li, Jane E. Sexton, Marta Alves-Simoes
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types. Using an advillin promoter, w
Externí odkaz:
https://doaj.org/article/f64ad67d3e6048f8af0b481f7da9b730
Autor:
M.A. Bangash, Sascha R.A. Alles, Sonia Santana-Varela, Queensta Millet, Shafaq Sikandar, Larissa de Clauser, Freija ter Heegde, Abdella M. Habib, Vanessa Pereira, Jane E. Sexton, Edward C. Emery, Shengnan Li, Ana P. Luiz, Janka Erdos, Samuel J. Gossage, Jing Zhao, James J. Cox, John N. Wood
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expres
Externí odkaz:
https://doaj.org/article/321b7fa64d604323a2606b1a61824c71
Autor:
Kathryn Quick, Jing Zhao, Niels Eijkelkamp, John E. Linley, Francois Rugiero, James J. Cox, Ramin Raouf, Martine Gringhuis, Jane E. Sexton, Joel Abramowitz, Ruth Taylor, Andy Forge, Jonathan Ashmore, Nerissa Kirkwood, Corné J. Kros, Guy P. Richardson, Marc Freichel, Veit Flockerzi, Lutz Birnbaumer, John N. Wood
Publikováno v:
Open Biology, Vol 2, Iss 5 (2012)
Summary Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly ad
Externí odkaz:
https://doaj.org/article/c8717fd280dc494cb9d546d9c1fe8e6a
Autor:
Jane E. Sexton, Yury D. Bogdanov, Samuel J. Gossage, Shengnan Li, Andrei L. Okorokov, Larissa de Clauser, Federico Iseppon, Ana P. Luiz, Jing Zhao, John N. Wood, Sonia Santana-Varela, James J. Cox, Marta Alves-Simoes
Publikováno v:
Wellcome Open Research. 6:250
Background: Somatosensation depends on primary sensory neurons of the trigeminal and dorsal root ganglia (DRG). Transcriptional profiling of mouse DRG sensory neurons has defined at least 18 distinct neuronal cell types. Using an advillin promoter, w
Autor:
Queensta Millet, Jane E. Sexton, Julie Tordo, Alice M. Fuller, Michael Linden, Stephen E. Moss, Jyoti S. Choudhary, Els Henckaerts, Stéphane Lolignier, Vanessa Pereira, Richard J. Lewis, Sonia Santana-Varela, John N. Wood, Ramin Raouf, Anna M Biller, Mark O. Collins
Publikováno v:
Science Signaling
Science Signaling, American Association for the Advancement of Science, 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩
Science Signaling, American Association for the Advancement of Science (AAAS), 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩
Raouf, R, Lolignier, S, Sexton, J E, Millet, Q, Santana-Varela, S, Biller, A, Fuller, A M, Pereira, V, Choudhary, J S, Collins, M O, Moss, S E, Lewis, R, Tordo, J, Henckaerts, E, Linden, M & Wood, J N 2018, ' Inhibition of somatosensory mechanotransduction by annexin A6 ', Science Signaling, vol. 11, no. 535, eaao2060 . https://doi.org/10.1126/scisignal.aao2060
Science Signaling, American Association for the Advancement of Science, 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩
Science Signaling, American Association for the Advancement of Science (AAAS), 2018, 11 (535), ⟨10.1126/scisignal.aao2060⟩
Raouf, R, Lolignier, S, Sexton, J E, Millet, Q, Santana-Varela, S, Biller, A, Fuller, A M, Pereira, V, Choudhary, J S, Collins, M O, Moss, S E, Lewis, R, Tordo, J, Henckaerts, E, Linden, M & Wood, J N 2018, ' Inhibition of somatosensory mechanotransduction by annexin A6 ', Science Signaling, vol. 11, no. 535, eaao2060 . https://doi.org/10.1126/scisignal.aao2060
Patients with osteoarthritis experience pain when moving or, sometimes, touching the affected joints. Raouf et al. identified proteins that bound to a toxin that inhibits mechanically induced pain, including the membrane-binding protein annexin A6. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817616de32e174a126da9c7636d79807
https://hal.uca.fr/hal-03512530
https://hal.uca.fr/hal-03512530
Autor:
Sascha R.A. Alles, Janka Erdos, Queensta Millet, Freija Ter Heegde, Shengnan Li, Vanessa Pereira, Jane E. Sexton, John N. Wood, Edward C. Emery, M A Bangash, Jing Zhao, Abdella M. Habib, Ana P. Luiz, Shafaq Sikandar, Samuel J. Gossage, Larissa de Clauser, Sonia Santana-Varela, James J. Cox
Publikováno v:
Wellcome Open Research
Bangash, M A, Alles, S R A, Santana-varela, S, Millet, Q, Sikandar, S, De Clauser, L, Ter Heegde, F, Habib, A M, Pereira, V, Sexton, J E, Emery, E C, Li, S, Luiz, A P, Erdos, J, Gossage, S J, Zhao, J, Cox, J J & Wood, J N 2018, ' Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions ', Wellcome Open Research, vol. 3, pp. 78 . https://doi.org/10.12688/wellcomeopenres.14641.1
Bangash, M A, Alles, S R A, Santana-varela, S, Millet, Q, Sikandar, S, De Clauser, L, Ter Heegde, F, Habib, A M, Pereira, V, Sexton, J E, Emery, E C, Li, S, Luiz, A P, Erdos, J, Gossage, S J, Zhao, J, Cox, J J & Wood, J N 2018, ' Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions ', Wellcome Open Research, vol. 3, pp. 78 . https://doi.org/10.12688/wellcomeopenres.14641.1
Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expres
Publikováno v:
Annual review of pharmacology and toxicology. 58
Pain is an increasing clinical challenge affecting about half the population, with a substantial number of people suffering daily intense pain. Such suffering can be linked to the dramatic rise in opioid use and associated deaths in the United States
Autor:
Vanessa Pereira, Alice M. Fuller, Stephen E. Moss, John N. Wood, Jyoti S. Choudhary, Sonia Santana-Varela, Queensta Millet, Ramin Raouf, Julie Tordo, Michael Linden, Mark O. Collins, Anna M Biller, Jane E. Sexton, Stéphane Lolignier
Sensory neuron mechanically-activated slowly adapting currents have been linked to noxious mechanosensation. We identified a Conotoxin, Noxious Mechanosensation Blocker -1, that blocks such currents selectively and inhibits mechanical pain Using an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b188e9ae1795d7f52a0c1a188afea1da
Autor:
Jörg Isensee, Leonhardt Krahé, Tim Hucho, Vanessa Pereira, Jane E. Sexton, Xiaohui Sun, Edward C. Emery, John N. Wood, Katharina Moeller
Genetic loss of the voltage-gated sodium channel Na(v)1.7 (Nav1.7(-/-)) results in lifelong insensitivity to pain in mice and humans. One underlying cause is an increase in the production of endogenous opioids in sensory neurons. We analyzed whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d8165cf046908767a821f0944aecb7
https://europepmc.org/articles/PMC6711404/
https://europepmc.org/articles/PMC6711404/
Autor:
Jane E, Sexton, Terri, Desmonds, Kathryn, Quick, Ruth, Taylor, Joel, Abramowitz, Andy, Forge, Corné J, Kros, Lutz, Birnbaumer, John N, Wood
Publikováno v:
Neuroscience Letters
Highlights • The contribution of multiple TRPC channels on mechanosensory function is demonstrated. • We observe a critical role for TRPC channels in touch sensation. • TRPC channels contribute to cutaneous and auditory mechanosensation in a co