Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jane D. Wobken"'
Autor:
Erik S. Carlson, Anna Petryk, Phu V. Tran, Michael K. Georgieff, Stephanie J. B. Fretham, Jane D. Wobken
Publikováno v:
Hippocampus. 22:1691-1702
Iron is a necessary substrate for neuronal function throughout the lifespan, but particularly during development. Early life iron deficiency (ID) in humans (late gestation through 2–3 years) results in persistent cognitive and behavioral abnormalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c4a85cbd027c56eff8ee4144ca4202
https://doi.org/10.1002/hipo.22004
https://doi.org/10.1002/hipo.22004
Autor:
Jane D. Wobken, Stephanie J. B. Fretham, Phu V. Tran, Bradley S. Miller, Michael K. Georgieff
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 302:E316-E324
Gestational-neonatal iron deficiency, a common micronutrient deficiency affecting the offspring of more than 30% of pregnancies worldwide, leads to long-term cognitive and behavioral abnormalities. Preclinical models of gestational-neonatal iron defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd030ac466a01d7a456a1452eb755304
https://doi.org/10.1152/ajpendo.00369.2011
https://doi.org/10.1152/ajpendo.00369.2011
Publikováno v:
Developmental Neuroscience. 32:238-248
The hippocampus develops rapidly during the late fetal and early postnatal periods. Fetal/neonatal iron deficiency anemia (IDA) alters the genomic expression, neurometabolism and electrophysiology of the hippocampus during the period of IDA and, stri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3548b49e7d4cc196c03c2af5ba42e1ae
https://doi.org/10.1159/000314341
https://doi.org/10.1159/000314341
Publikováno v:
Brain Research. 1237:195-203
The hippocampus is especially sensitive to the effects of gestational and neonatal iron deficiency, even after iron repletion. This study compared the effects of iron deficiency, maintained from gestational day 2 to postnatal day (P)7, on “delay”
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b3de41cd931829dc1d06a1f8119b94
https://doi.org/10.1016/j.brainres.2008.08.079
https://doi.org/10.1016/j.brainres.2008.08.079
Autor:
Jenni L. Bradley, Stephen L. Clarke, Michael K. Georgieff, Elizabeth A. Leibold, Richard S. Eisenstein, Jane D. Wobken, Kimberly B. Zumbrennen, Z. Leah Harris
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 287:R894-R901
Placental iron transport during the last trimester of pregnancy determines the iron endowment of the neonate. Iron transport is a function of the major iron transport proteins: transferrin receptor-1 (TfR-1) and ferroportin-1 (FPN-1). The mRNAs for T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321026d709e98d4120960c086332e2e9
https://doi.org/10.1152/ajpregu.00525.2003
https://doi.org/10.1152/ajpregu.00525.2003
Autor:
James R. Connor, Ashajyothi M. Siddappa, Kelly Casperson, Elizabeth A. Leibold, Michael K. Georgieff, Raghavendra Rao, Jane D. Wobken
Publikováno v:
Pediatric Research. 53:800-807
Iron plays an important role in numerous vital enzyme systems in the perinatal brain. The membrane proteins that mediate iron transport [transferrin receptor (TfR) and divalent metal transporter 1 (DMT-1)] and the iron regulatory proteins (IRP-1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b6d6ae44dba5d66ea13b0ac59d3bc3
https://doi.org/10.1203/01.pdr.0000058922.67035.d5
https://doi.org/10.1203/01.pdr.0000058922.67035.d5
Publikováno v:
Developmental Neuroscience. 25:412-420
Iron deficiency early in life is associated with cognitive disturbances that persist beyond the period of iron deficiency. Within cognitive processing circuitry, the hippocampus is particularly susceptible to insults during the perinatal period. Duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15559db17901acac17413045894d7e01
https://doi.org/10.1159/000075667
https://doi.org/10.1159/000075667
Early-life iron deficiency anemia (IDA) alters the expression of critical genes involved in neuronal dendritic structural plasticity of the hippocampus, thus contributing to delayed maturation of electrophysiology, and learning and memory behavior in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feba00a68e135ef109d8dd168b99a12
https://europepmc.org/articles/PMC3888229/
https://europepmc.org/articles/PMC3888229/
Publikováno v:
The Journal of Pediatrics. 127:308-311
Neonatal liver (storage) but not heart (nonstorage) tissue iron concentrations were reduced by 60% at autopsy in 15 newborn infants who had gestations complicated by uteroplacental insufficiency because of maternal hypertension or Potter syndrome. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84acf1a0c39632de6dff8ee621553fc8
https://doi.org/10.1016/s0022-3476(95)70317-9
https://doi.org/10.1016/s0022-3476(95)70317-9
Autor:
Charles A. Nelson, Jane D. Wobken, Raghavendra Rao, Marissa deUngria, Monica Luciana, Michael K. Georgieff
Publikováno v:
Obstetric and Gynecologic Survey. 56:191-193
Intrauterine growth retardation and diabetes mellitus during human gestation result in significant losses of fetal and neonatal brain iron. Brain iron deficiency is associated with impaired cognitive processes including memory and attention. The regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b7528ae15ca6f36a554ac388942096
https://doi.org/10.1097/00006254-200104000-00003
https://doi.org/10.1097/00006254-200104000-00003