Výsledky vyhledávání - "Jane D. Robertson"

Data from Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization

Purpose: Maintenance therapy with olaparib has improved progression-free survival in women with high-grade serous ovarian cancer (HGSOC), particularly those harboring BRCA1/2 mutations. The objective of this study was to characterize long-term (LT) v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f3cf8b7ca62d919c2266027f7eb78d
https://doi.org/10.1158/1078-0432.c.6527036.v1

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Supplementary material from Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization

Supplementary Figure 1. Mutational analysis of TP53 in the olaparib arm. (A) Analysis of TP53 mutation type. (B) BRCA1 and BRCA2 mutation type Supplementary Table 1. Platinum sensitivity and outcome on olaparib maintenance treatment. Supplementary Ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dce4e67ff8abc1435358f47967de32e
https://doi.org/10.1158/1078-0432.22468700.v1

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Dynamics of telomere shortening in neutrophils and T lymphocytes during ageing and the relationship to skewed X chromosome inactivation patterns

Autor: Nydia G Testa, Rosemary E. Gale, Mark Dougal, Jane D. Robertson, David C. Linch, Robert Wynn, Rajesh Chopra

Publikováno v: British Journal of Haematology. 109:272-279

Human haemopoiesis undergoes profound changes throughout life, resulting in compromised regenerative capacity of haemopoietic stem cells. It has been suggested that telomere shortening results in senescence of haemopoietic stem cell subsets and may i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a0023098f0031e458adf17069828714
https://doi.org/10.1046/j.1365-2141.2000.01970.x

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