Výsledky vyhledávání - "Jane Croft Harrelson"

Biochemical and pharmacologic properties of 2614W94, a reversible, competitive inhibitor of monoamine oxidase-A

Autor: Philip W. Scates, Morton Harfenist, Jane Croft Harrelson, John E. Hughes, Ron M. Norton, Helen L. White, Barrett R. Cooper, Greg C. Rigdon, Thomas E. Johnson, Stacey A. Jones

Publikováno v: Drug Development Research. 45:1-9

2614W94 [3-(1-trifluoromethyl)ethoxyphenoxathiin 10,10-dioxide] is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and a Ki value of 1.6 nM with serotonin as substrate. In pretreated rats, the ED50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44a25e0b5600923f48269e88d37572b4
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<1::aid-ddr1>3.0.co

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High Performance Liquid Chromatographic Assay for Cisatracurium and Its Metabolites in Human Urine

Autor: Jane Croft Harrelson, B. J. Bryant, D. Ryan Cook, Charles D. James

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 20:2041-2051

An HPLC assay for the analysis of cisatracurium and its metabolites, laudanosine and the cis-monoquaternary alcohol (MQA), in human urine was developed. The assay involved solid-phase extraction followed by HPLC analysis on a strong cation exchange c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9ccba7742d1a782a1891d2533cccbd0
https://doi.org/10.1080/10826079708005563

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A High Performance Liquid Chromato-Graphic Method for a Novel Serotonin Reuptake Inhibitor 5-Chloro-2-[[2-(dimethylamino)methyl]phenyl]benzyl Alcohol (403U76)

Autor: Richard M. Welch, Jane Croft Harrelson, Ivin S. Silver, Robert M. Wurm

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 19:1117-1126

A sensitive and selective high performance liquid chromatographic assay using UV-detection was developed for the analysis of 403U76, a structurally novel serotonin reuptake inhibitor, and two demethylated metabolites, 515U88 and 336U76 in rat plasma.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db2d3ff2c1ab1a69d038e4dbd4fb8145
https://doi.org/10.1080/10826079608006306

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High-Performance Liquid Chromatographic Assay with Ultraviolet Detection for the Analysis of BW 1370U87 and Its Two Major Metabolites in Human Plasma

Autor: Steven Wintermute, Thomas E. Johnson, Lewis L. Kanics, Richard M. Welch, Jane Croft Harrelson

Publikováno v: Journal of Liquid Chromatography. 16:2387-2398

A sensitive and selective high performance liquid chromatographic assay with UV detection was developed for the analysis of BW 1370U87, a novel MAO-A inhibitor, and its major metabolites, BW 183U88 and BW 1003U88 in human plasma. The compounds were i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e4627691e8eb3d5ebc38ad452e32b0
https://doi.org/10.1080/10826079308020993

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Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry

Autor: Gordon J. Dear, Anne E. Jones, Jane Croft Harrelson, Stephen Pleasance, Thomas E. Johnson

Publikováno v: Rapid communications in mass spectrometry : RCM. 9(14)

Cisatracurium, (1R, 1'R, 2R, 2'R)-2,2-[1,5-pentanediylbis-[oxy(3-oxo- 3,1-propanediyl]]bis[1-[(3,4-dimethoxyphenyl)-methyl]-1,2,3,4- tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] dibenzenesulphonate (51W89), is an intermediate-acting neuromuscular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c223b2f58335337d2991248594443a99
https://pubmed.ncbi.nlm.nih.gov/8534894

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Pharmacokinetics of mivacurium in normal patients and in those with hepatic or renal failure

Autor: Jane Croft Harrelson, B. Samara, J.A. Freeman, D. R. Cook, R. M. Welch, Richard L. Stiller, Yoogoo Kang, A. A. Lai, S Aggarwal

Publikováno v: British journal of anaesthesia. 69(6)

We have determined the pharmacokinetics and duration of action of a bolus dose of mivacurium (0.15 mg kg-1) during isoflurane and nitrous oxide anaesthesia in nine patients with normal renal and liver function, nine patients undergoing cadaveric kidn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d140c52189b6c5c525a4df4dc617848
https://pubmed.ncbi.nlm.nih.gov/8123424

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Stereoselective high-performance liquid chromatographic assay with fluorometric detection for the isomers of mivacurium in human plasma

Autor: Richard M. Welch, Charles D. James, Alan Robert Brown, Jane Croft Harrelson

Publikováno v: Journal of chromatography. 578(2)

A high-performance liquid chromatographic assay with fluorometric detection was developed for the analysis of the stereoisomers of mivacurium, a new short-acting neuromuscular blocker, in plasma. The isomers were isolated from plasma by solid-phase e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cfef4cdfa8afa80de0d1863c8b8ea1
https://pubmed.ncbi.nlm.nih.gov/1400811

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Pharmacokinetics of Mivacurium in Normal Patients and Those with Hepatic or Renal Failure

Autor: A. A. Lai, B. Samara, R. L. Stiller, Jane Croft Harrelson, Judith A. Freeman, Yoogoo Kang, S Aggarwal, R. M. Welch, D. R. Cook

Publikováno v: Survey of Anesthesiology. 37:197

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e370675d750448a8b5d9b81ad4a7043
https://doi.org/10.1097/00132586-199308000-00018

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