Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jane Chua-Couzens"'
Autor:
Karen Chen, William C. Mobley, Scott E. Daniels, Randolph M. Johnson, Yuling Sun, Enrico Alleva, Elaine J. Carlson, Charles J. Epstein, David M. Holtzman, David J. Fontana, Daniela Santucci, Jane Chua-Couzens, Joshua Kilbridge
Publikováno v:
Proceedings of the National Academy of Sciences. 93:13333-13338
To study the pathogenesis of central nervous system abnormalities in Down syndrome (DS), we have analyzed a new genetic model of DS, the partial trisomy 16 (Ts65Dn) mouse. Ts65Dn mice have an extra copy of the distal aspect of mouse chromosome 16, a
Autor:
Joshua Kilbridge, Ahmad Salehi, Jonathan D. Cooper, Belichenko Pavel Vasilyevich, William C. Mobley, Jane Chua-Couzens, Charles L. Howe, Elaine J. Carlson, Charles J. Epstein, Jean-Dominique Delcroix
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(18)
Age-related degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive decline in Alzheimer's disease and Down's syndrome. With aging, the partial trisomy 16 (Ts65Dn) mouse model of Down's syndrome exhibited reductions in BF
Autor:
William C. Mobley, Larry L. Butcher, Tracy T. Yeo, Jonathan D. Cooper, Frank M. Longo, Jane Chua-Couzens, Dale E. Bredesen, Janice S. Valletta
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 17(20)
Emerging evidence suggests that the p75 neurotrophin receptor (p75NTR) mediates cell death; however, it is not known whether p75NTRnegatively regulates other neuronal phenotypes. We found that mice null for p75NTRdisplayed highly significant increase
Autor:
David M. Holtzman, Jane Chua-Couzens, Houhui Xia, Yiwen Li, William C. Mobley, David S. Bredt, Sandra Lee
Publikováno v:
Neurochemical research. 21(7)
Nerve growth factor (NGF) acts through the receptor tyrosine kinase trkA to serve as a trophic factor for cholinergic neurons in the medial septal nucleus and vertical limb of the diagonal band. We have previously shown that the neuronal isoform of n
Autor:
William C. Mobley, Jane Chua-Couzens, David L. Kaplan, Beat Knusel, Yiwen Li, Douglas O. Clary, Lawrence F. Kromer, David M. Holtzman
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 15(4)
TrkA is a receptor tyrosine kinase whose activation transduces NGF signaling. TrkA expression has been demonstrated in NGF-responsive adult basal forebrain cholinergic neurons (BFCNs). Several lines of evidence have suggested that endogenous NGF play