Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jane Cheeseman"'
Autor:
Hussein Al-Mossawi, Nicole Yager, Chelsea A. Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A. Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C. Knight, Paul Bowness, Benjamin P. Fairfax
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Interleukin-7 (IL-7) is a central cytokine in T cell homeostasis. Here the authors show that allelic variation at rs6897932, an autoimmune GWAS risk allele at IL7R, regulates surface and soluble IL-7R in stimulated monocytes, indicating a function of
Externí odkaz:
https://doaj.org/article/049d83c02bd448feb336fe01a336bc58
Autor:
Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W Rayner, Reedik Mägi, Fredrik H Pettersson, John Broxholme, Matt J Neville, Quin F Wills, Jane Cheeseman, GIANT Consortium, MolPAGE Consortium, Maxine Allen, Chris C Holmes, Tim D Spector, Jan Fleckner, Mark I McCarthy, Fredrik Karpe, Cecilia M Lindgren, Krina T Zondervan
Publikováno v:
PLoS Genetics, Vol 8, Iss 2, p e1002505 (2012)
Metabolic Syndrome (MetS) is highly prevalent and has considerable public health impact, but its underlying genetic factors remain elusive. To identify gene networks involved in MetS, we conducted whole-genome expression and genotype profiling on abd
Externí odkaz:
https://doaj.org/article/48c00fdd38354c18b5237e49bea1cf97
Autor:
Mahesh M Umapathysivam, Elisa Araldi, Benoit Hastoy, Adem Y Dawed, Hasan Vatandaslar, Shahana Sengupta, Adrian Kaufmann, Søren Thomsen, Bolette Hartmann, Anna E Jonsson, Hasan Kabakci, Swaraj Thaman, Niels Grarup, Christian T Have, Kristine Færch, Anette P Gjesing, Sameena Nawaz, Jane Cheeseman, Matthew J Neville, Oluf Pedersen, Mark Walker, Christopher Jennison, Andrew T Hattersley, Torben Hansen, Fredrik Karpe, Jens J Holst, Angus G Jones, Michael Ristow, Mark I McCarthy, Ewan R Pearson, Markus Stoffel, Anna L Gloyn
Patients with type 2 diabetes vary in their response to currently available therapeutic agents (including GLP-1 receptor agonists) leading to suboptimal glycemic control and increased risk of complications. We show that human carriers of hypomorphic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::157451176660a0e343840228d18dc298
https://doi.org/10.1101/2023.04.07.23288197
https://doi.org/10.1101/2023.04.07.23288197
Publikováno v:
BMJ Open Quality, Vol 7, Iss 3 (2018)
Delivering high quality care in acute psychiatry requires a coordinated approach from a multidisciplinary team (MDT). Weekly ward rounds are an important forum for reviewing a patient’s progress and developing a personalised care plan for the comin
Externí odkaz:
https://doaj.org/article/1d40aa200e5843aa9ceb1cd8e7ab9b0c
Autor:
Paul Bowness, Isar Nassiri, Chelsea A Taylor, James J. Gilchrist, Wanseon Lee, Benjamin P. Fairfax, Evelyn Lau, Julian C. Knight, Matt J. Neville, E Mahe, H Al-Mossawi, Seiko Makino, S Danielli, Nicole Yager, Laila Rizvi, J De Wit, Jane Cheeseman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
IL-7 is a key factor in T cell immunity and common variants at IL7R, encoding its receptor, are associated with autoimmune disease susceptibility. IL7R mRNA is induced in stimulated monocytes, yet a function for IL7R in monocyte biology remains unexp
Autor:
Hussein Al-Mossawi, Nicole Yager, Chelsea Taylor, Evelyn Lau, Sara Danielli, Jelle de Wit, James Gilchrist, Isar Nassiri, Elise A Mahe, Wanseon Lee, Laila Rizvi, Seiko Makino, Jane Cheeseman, Matt Neville, Julian C Knight, Paul Bowness, Benjamin P Fairfax
IL-7 is a key factor in T-cell immunity and IL7R polymorphisms are implicated in autoimmune pathogenesis. IL7R mRNA is induced in stimulated monocytes in a genetically determined manner, yet a role for IL7R in monocyte biology remains unexplored. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e14e4d9a885b4fffcc639faa6f58dcb
https://doi.org/10.1101/262410
https://doi.org/10.1101/262410
Autor:
Oliver A. Leach, Adam R. Johnson, Jane Cheeseman, Fredrik Karpe, Thomas R Barber, Gurman Kaur, Hayley G. Evans, Charles Eigenbrot, Adrian Cortes, Stephen Sawcer, Lars Fugger, Luke Jostins, Lydia Shipman, John Bell, Soren L. Faergeman, Calliope A. Dendrou, Kathrine E. Attfield, Christine Everett, Mark Ultsch, Alastair Compston, Gil McVean, Christiane Desel, Subita Balaram Kuttikkatte, Matt J. Neville
Publikováno v:
Dendrou, C A, Cortes, A, Shipman, L, Evans, H G, Attfield, K E, Jostins, L, Barber, T, Kaur, G, Kuttikkatte, S B, Leach, O A, Desel, C, Faergeman, S L, Cheeseman, J, Neville, M J, Sawcer, S, Compston, A, Johnson, A R, Everett, C, Bell, J I, Karpe, F, Ultsch, M, Eigenbrot, C, McVean, G & Fugger, L 2016, ' Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity ', Science Translational Medicine, vol. 8, no. 363, pp. 363ra149 . https://doi.org/10.1126/scitranslmed.aag1974
Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence reg
Autor:
Leanne Hodson, Fredrik Karpe, Toralph Ruge, Barbara A. Fielding, A. Louise Dennis, Sandy M. Humphreys, Keith N. Frayn, Jane Cheeseman
CONTEXT: Absence or excess of adipose tissue are both associated with metabolic complications, implying the importance of well-functioning adipose tissue present in normal amounts. Adipose tissue sequesters dietary fat and thus protects other tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cc4c28b413a3a869bb8725e2d2582b
https://ora.ox.ac.uk/objects/uuid:f6e00f61-5407-46c2-966e-1b0e992e11ed
https://ora.ox.ac.uk/objects/uuid:f6e00f61-5407-46c2-966e-1b0e992e11ed
Autor:
M Gilbert, Fredrik Karpe, Jane Cheeseman, A. Louise Dennis, Matt Neville, S. McQuaid, Toralph Ruge, Sandy M. Humphreys, Barbara A. Fielding, Keith N. Frayn, Leanne Hodson
Publikováno v:
Diabetes
OBJECTIVE Lipotoxicity and ectopic fat deposition reduce insulin signaling. It is not clear whether excess fat deposition in nonadipose tissue arises from excessive fatty acid delivery from adipose tissue or from impaired adipose tissue storage of in