Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jane C. Stewart"'
Autor:
Elizabeth G. Porter, Alisha Dhiman, Basudev Chowdhury, Benjamin C. Carter, Hang Lin, Jane C. Stewart, Majid Kazemian, Michael K. Wendt, Emily C. Dykhuizen
Publikováno v:
iScience, Vol 15, Iss , Pp 196-210 (2019)
Summary: Polybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly clear cell renal carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm-associated factors), and is characterized by six tandem
Externí odkaz:
https://doaj.org/article/1d1816adb31e482ea9e1fce69294c445
Autor:
Basudev Chowdhury, Elizabeth G Porter, Jane C Stewart, Christina R Ferreira, Matthew J Schipma, Emily C Dykhuizen
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153718 (2016)
Polybromo-1 (PBRM1) is a component of the PBAF (Polybromo-associated-BRG1- or BRM-associated factors) chromatin remodeling complex and is the second most frequently mutated gene in clear-cell renal cell Carcinoma (ccRCC). Mutation of PBRM1 is believe
Externí odkaz:
https://doaj.org/article/595651c6a9284fe5be6136d5bfc9c0a5
Autor:
Emily C. Dykhuizen, Benjamin Carter, Hang Lin, Michael K. Wendt, Alisha Dhiman, Basudev Chowdhury, Majid Kazemian, Elizabeth G. Porter, Jane C. Stewart
Publikováno v:
iScience
Department of Biochemistry Faculty Publications
iScience, Vol 15, Iss, Pp 196-210 (2019)
Department of Biochemistry Faculty Publications
iScience, Vol 15, Iss, Pp 196-210 (2019)
Summary Polybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly clear cell renal carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm-associated factors), and is characterized by six tandem b
Autor:
Majid Kazemian, Elizabeth G. Porter, Michael K. Wendt, Benjamin Carter, Jane C. Stewart, Hang Lin, Basudev Chowdhury, Alisha Dhiman, Emily C. Dykhuizen
SummaryPolybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly renal clear cell carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm Associated Factors) and is characterized by six tandem bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70941fa2c5c2358725e428df61a825ee
Autor:
James F. Naughton, Nikki Parker, Lindsey M. Fourez, Ryan Rothenbuhler, Linda M. Murphy, Joseph A. Reddy, Liang Cheng, Christopher P. Leamon, Jane C. Stewart, José A. Ramos-Vara, Iontcho Radoslavov Vlahov, Philip S. Low, Michael O. Koch, Patrick J. Klein, Deborah W. Knapp, Deepika Dhawan
Publikováno v:
Cancer Research. 73:875-884
Folate receptors (FR) may be of use for targeted delivery of cytotoxic drugs in invasive urothelial carcinoma (iUC), for which improved therapy is needed. FR expression and function in iUC were explored and the antitumor activity and toxicity of a fo
Autor:
G. A. Nagana Gowda, Jian Zhang, Deborah W. Knapp, Daniel Raftery, Jane C. Stewart, Siwei Wei, Lingyan Liu, Patty L. Bonney
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1822(11):1807-1814
Bladder cancer is one of the leading lethal cancers worldwide. With the high risk of recurrence for bladder cancer following the initial diagnoses, lifelong monitoring of patients is necessary. The lack of adequate sensitivity and specificity of curr
Autor:
Deborah W. Knapp, E.J. Arnold, Kean Ming Tan, Lindsey M. Fourez, Patty L. Bonney, Michael O. Childress, Jane C. Stewart
Publikováno v:
Journal of Veterinary Internal Medicine. 25:1385-1390
Background Transitional cell carcinoma (TCC) of the urinary bladder of dogs can be a difficult cancer to treat, and effective therapies are limited. Vinblastine has been used in humans with TCC and has potent anti-proliferative effects against canine
Autor:
David R. Jones, Lindsey M. Fourez, Andrea R. Masters, A.H. Abbo, Deborah W. Knapp, Jane C. Stewart
Publikováno v:
Journal of Veterinary Internal Medicine. 24:1124-1130
Background: Transitional cell carcinoma (TCC) is the most common cancer of the urinary tract in dogs. The most frequent cause of death is urinary obstruction from the primary tumor. Standard medical therapy for TCC is only partially effective. Hypoth
Publikováno v:
Urologic Oncology: Seminars and Original Investigations. 27:284-292
Objectives Urinary bladder cancer is the fifth most common form of cancer in humans in the United States. Urinary bladder cancer also occurs in pet dogs, and naturally-occurring bladder cancer in pet dogs very closely resembles invasive bladder cance
Publikováno v:
Molecular Cancer Therapeutics. 7:897-904
Transitional cell carcinoma of the urinary bladder is the second most common genitourinary malignancy in people in the United States. Cyclooxygenase-2 (COX-2) is overexpressed in bladder cancer. COX-2 inhibitors have had antitumor activity against bl