Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling

Autor: Matthew J. Elder, Steve J. Webster, Timothy J. Fitzmaurice, Aran S. D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, Jane C. Goodall

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a

Externí odkaz: https://doaj.org/article/d37c0112f5e9441b8aa4a1a774e80bea

β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production

Autor: Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immuni

Externí odkaz: https://doaj.org/article/7b61fa02b4424390890f997b33134bad

TCR usage, gene expression and function of two distinct FOXP3 + Treg subsets within CD4 + CD25 hi T cells identified by expression of CD39 and CD45RO

Autor: Dmitriy M. Chudakov, Lei Jiang, Ekaterina V. Putintseva, Hill Gaston, Ting Li, Libin Zhang, Lingying Ye, Huji Xu, Giles S.H. Yeo, Li Lin, Jian Yin, Mikhail Shugay, Brian Y.H. Lam, Wei Liu, Xin Wu, Jane C. Goodall

Publikováno v: Immunology & Cell Biology. 94:293-305

FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4413e5d95da12d3b5af88043a682862
https://doi.org/10.1038/icb.2015.90

New concepts in Chlamydia induced inflammasome responses

Autor: Jane C. Goodall, Steve J. Webster

Publikováno v: Microbes and infection. 20(7-8)

Since the concept of the inflammasome was introduced by Martinon, Burns and Tschopp in 2002, there has been an exponential increase in our understanding of how inflammasomes (caspase activating molecular platforms) regulate innate inflammatory respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f21668a255af335954daef2cef86e1
https://pubmed.ncbi.nlm.nih.gov/29248634

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

Autor: Severine Vermeire, Morten H. Vatn, Simone Lipinski, Xiao Liu, Sebastian Zeissig, Manuel A. Rivas, Hu Zhang, Mauro D'Amato, Manfred Kayser, Bernhard O. Boehm, Jeremy D. Sanderson, Cisca Wijmenga, Anna Latiano, Nadezhda Tsankova Doncheva, Ulla Vogel, Rinse K. Weersma, Jurgita Skieceviciene, Markus M. Nöthen, Stefan Schreiber, Tom H. Karlsen, Vito Annese, Carlo Berzuini, Fuman Jiang, James Lee, Mario Albrecht, Tao Jiang, Susanna Nikolaus, Thomas Illig, Qing Liu, Stephan Brand, Carsten Büning, David P. Strachan, Andreas Keller, Jun Wang, Michael Nothnagel, Andreas Till, Juliane Winkelmann, Miquel Sans, Jane C. Goodall, Philip Rosenstiel, David Ellinghaus, Andre Franke, Michael Krawczak, Richard H. Duerr, Cyriel Y. Ponsioen, Miles Parkes, Jonas Halfvarson, Björn Stade, Michael Forster, Vibeke Andersen, Suresh Subramani, Eva Ellinghaus, Limas Kupčinskas, Gabriele Mayr, Jürgen Glas, Paul Rutgeerts, Christopher G. Mathew, Robert Häsler, Wendy L. McArdle, Yana Bromberg, Mark J. Daly

Publikováno v: Gastroenterology, 145(2), 339-347. W.B. Saunders Ltd
Gastroenterology, 145(2), 339-347. W B SAUNDERS CO-ELSEVIER INC
Gastroenterology, 145(2), 339-347. W.B. Saunders
Ellinghaus, D, Zhang, H, Zeissig, S, Lipinski, S, Till, A, Jiang, T, Stade, B, Bromberg, Y, Ellinghaus, E, Keller, A, Rivas, M A, Skieceviciene, J, Doncheva, N T, Liu, X, Liu, Q, Jiang, F, Forster, M, Mayr, G, Albrecht, M, Häsler, R, Boehm, B O, Goodall, J, Berzuini, C R, Lee, J, Andersen, V, Vogel, U B, Kupcinskas, L, Kayser, M, Krawczak, M, Nikolaus, S, Weersma, R K, Ponsioen, C Y, Sans, M, Wijmenga, C, Strachan, D P, McArdle, W L, Vermeire, S, Rutgeerts, P, Sanderson, J D, Mathew, C G, Vatn, M H, Wang, J, Nöthen, M M, Duerr, R H, Büning, C, Brand, S, Glas, J, Winkelmann, J, Illig, T, Latiano, A, Annese, V, Halfvarson, J, D'Amato, M, Daly, M J, Nothnagel, M, Karlsen, T H, Subramani, S, Rosenstiel, P, Schreiber, S, Parkes, M & Franke, A 2013, ' Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies ', Gastroenterology, vol. 145, no. 2, 23727859, pp. 339-347 . https://doi.org/10.1053/j.gastro.2013.04.040, https://doi.org/10.1053/j.gastro.2013.04.040

Background & Aims Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8578ee5bf2838341c1d6e35ab72c0c4
https://research.rug.nl/en/publications/d9e69cad-10a0-4485-b996-25f5f3cb6c91