GDF15 antagonism limits severe heart failure and prevents cardiac cachexia in mice

Autor: Minoru Takaoka, John A. Tadross, Ali Al-Hadithi, Rocío Villena-Gutiérrez, Jasper Tromp, Shazia Absar, Marcus Au, James Harrison, Anthony P. Coll, Stefan J. Marciniak, Debra Rimmington, Eduardo Oliver, Borja Ibáñez, Adriaan A. Voors, Stephen O’Rahilly, Ziad Mallat, Jane C. Goodall

Heart failure and associated cachexia is an unresolved and important problem. We report a new model of severe heart failure that consistently results in cachexia. Mice lacking the integrated stress response (ISR) induced eIF2α phosphatase, PPP1R15A,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec273ed5489a7538e35e97c7a1cb25ac
https://doi.org/10.1101/2022.09.06.506633

Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection.

Autor: Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall

Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)

The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo

Externí odkaz: https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5

TCR usage, gene expression and function of two distinct FOXP3 + Treg subsets within CD4 + CD25 hi T cells identified by expression of CD39 and CD45RO

Autor: Dmitriy M. Chudakov, Lei Jiang, Ekaterina V. Putintseva, Hill Gaston, Ting Li, Libin Zhang, Lingying Ye, Huji Xu, Giles S.H. Yeo, Li Lin, Jian Yin, Mikhail Shugay, Brian Y.H. Lam, Wei Liu, Xin Wu, Jane C. Goodall

Publikováno v: Immunology & Cell Biology. 94:293-305

FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4413e5d95da12d3b5af88043a682862
https://doi.org/10.1038/icb.2015.90

New concepts in Chlamydia induced inflammasome responses

Autor: Jane C. Goodall, Steve J. Webster

Publikováno v: Microbes and infection. 20(7-8)

Since the concept of the inflammasome was introduced by Martinon, Burns and Tschopp in 2002, there has been an exponential increase in our understanding of how inflammasomes (caspase activating molecular platforms) regulate innate inflammatory respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f21668a255af335954daef2cef86e1
https://pubmed.ncbi.nlm.nih.gov/29248634

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

Autor: Severine Vermeire, Morten H. Vatn, Simone Lipinski, Xiao Liu, Sebastian Zeissig, Manuel A. Rivas, Hu Zhang, Mauro D'Amato, Manfred Kayser, Bernhard O. Boehm, Jeremy D. Sanderson, Cisca Wijmenga, Anna Latiano, Nadezhda Tsankova Doncheva, Ulla Vogel, Rinse K. Weersma, Jurgita Skieceviciene, Markus M. Nöthen, Stefan Schreiber, Tom H. Karlsen, Vito Annese, Carlo Berzuini, Fuman Jiang, James Lee, Mario Albrecht, Tao Jiang, Susanna Nikolaus, Thomas Illig, Qing Liu, Stephan Brand, Carsten Büning, David P. Strachan, Andreas Keller, Jun Wang, Michael Nothnagel, Andreas Till, Juliane Winkelmann, Miquel Sans, Jane C. Goodall, Philip Rosenstiel, David Ellinghaus, Andre Franke, Michael Krawczak, Richard H. Duerr, Cyriel Y. Ponsioen, Miles Parkes, Jonas Halfvarson, Björn Stade, Michael Forster, Vibeke Andersen, Suresh Subramani, Eva Ellinghaus, Limas Kupčinskas, Gabriele Mayr, Jürgen Glas, Paul Rutgeerts, Christopher G. Mathew, Robert Häsler, Wendy L. McArdle, Yana Bromberg, Mark J. Daly

Publikováno v: Gastroenterology, 145(2), 339-347. W.B. Saunders Ltd
Gastroenterology, 145(2), 339-347. W B SAUNDERS CO-ELSEVIER INC
Gastroenterology, 145(2), 339-347. W.B. Saunders
Ellinghaus, D, Zhang, H, Zeissig, S, Lipinski, S, Till, A, Jiang, T, Stade, B, Bromberg, Y, Ellinghaus, E, Keller, A, Rivas, M A, Skieceviciene, J, Doncheva, N T, Liu, X, Liu, Q, Jiang, F, Forster, M, Mayr, G, Albrecht, M, Häsler, R, Boehm, B O, Goodall, J, Berzuini, C R, Lee, J, Andersen, V, Vogel, U B, Kupcinskas, L, Kayser, M, Krawczak, M, Nikolaus, S, Weersma, R K, Ponsioen, C Y, Sans, M, Wijmenga, C, Strachan, D P, McArdle, W L, Vermeire, S, Rutgeerts, P, Sanderson, J D, Mathew, C G, Vatn, M H, Wang, J, Nöthen, M M, Duerr, R H, Büning, C, Brand, S, Glas, J, Winkelmann, J, Illig, T, Latiano, A, Annese, V, Halfvarson, J, D'Amato, M, Daly, M J, Nothnagel, M, Karlsen, T H, Subramani, S, Rosenstiel, P, Schreiber, S, Parkes, M & Franke, A 2013, ' Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies ', Gastroenterology, vol. 145, no. 2, 23727859, pp. 339-347 . https://doi.org/10.1053/j.gastro.2013.04.040, https://doi.org/10.1053/j.gastro.2013.04.040

Background & Aims Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8578ee5bf2838341c1d6e35ab72c0c4
https://research.rug.nl/en/publications/d9e69cad-10a0-4485-b996-25f5f3cb6c91