Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jane Boesen"'
Autor:
Per Nørgaard, Jing Su, Jane Boesen Frantzen, Zhiru Yang, Anne Bugge, Chih-Chuan Chang, Linu M. John, Anna Secher, Zhenhua He, Haisun Zhu, Tao Huang, Wei Yang, Kristian Tage Hansen, Xiaoai Wu, Xiang Gao, Sarah J Paulsen, Sebastian Beck Jørgensen, Jacob Jeppesen, Zhe Sun, Linda Yang, Haibin Chen, Bing Shan, Xun Li, Karin Hultman, Jishu Wang, Søren Berg Padkjær, Dennis Madsen
Publikováno v:
Nature Medicine. 23:1158-1166
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate receptor of GDF15 is unknown. Here we show that GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7309da29b5ef10acefc642a3c77d83
https://doi.org/10.1038/nm.4394
https://doi.org/10.1038/nm.4394
Autor:
Günther H.J. Peters, Kasper Damgaard Tidemand, Pernille Harris, Hans Erik Mølager Christensen, Niclas Hoeck, Jane Boesen
Publikováno v:
Tidemand, K D, Christensen, H E M, Hoeck, N, Harris, P, Boesen, J & Peters, G H J 2016, ' Stabilization of Tryptophan Hydroxylase 2 by L-Phenylalanine Induced Dimerization ', F E B S Open Bio, vol. 6, no. 10, pp. 987-999 . https://doi.org/10.1002/2211-5463.12100
FEBS Open Bio
FEBS Open Bio
Tryptophan hydroxylase 2 (TPH2) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. Full-length TPH2 is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1988c0e3f5ef874ee4035fa2d194875
https://orbit.dtu.dk/en/publications/fab2fb05-4db6-4ed0-9bfd-0dd3381553ac
https://orbit.dtu.dk/en/publications/fab2fb05-4db6-4ed0-9bfd-0dd3381553ac
Publikováno v:
Journal of Inorganic Biochemistry. 104:136-145
Insight into the nature of oxygen activation in tryptophan hydroxylase has been obtained from density functional computations. Conformations of O(2)-bound intermediates have been studied with oxygen trans to glutamate and histidine, respectively. An
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de84bfcda3919a55bcd78299af935fdc
https://doi.org/10.1016/j.jinorgbio.2009.10.010
https://doi.org/10.1016/j.jinorgbio.2009.10.010
Autor:
Jane Boesen, Trine V. Vendelboe, Pernille Harris, Astrid Munch, Hans Erik Mølager Christensen, Michael Ericsson Skovbo Nielsen, Charlotte Rode Petersen
Publikováno v:
Protein Expression and Purification. 57:116-126
Tryptophan hydroxylase (TPH) [EC 1.14.16.4] catalyzes the conversion of tryptophan to 5-hydroxytryptophan, which is the first and rate-determining step in the biosynthesis of the neurotransmitter serotonin. We have expressed the catalytic domain of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc2407983f04240967be9a3d541c948
https://doi.org/10.1016/j.pep.2007.10.016
https://doi.org/10.1016/j.pep.2007.10.016
Akademický článek
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Autor:
Pernille Efferbach Karlsen, Jane Boesen, Hans Erik Mølager Christensen, Michael Skovbo Windahl
Publikováno v:
The protein journal. 28(9-10)
Tryptophan hydroxylase exists in two isoforms: Isoform 1 catalyses the first and rate-limiting step in the synthesis of serotonin in the peripheral parts of the body while isoform 2 catalyses this step in the brain. The catalytic domains of human try
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfec618e8412dc4df7e7b733540332ee
https://pubmed.ncbi.nlm.nih.gov/19816759
https://pubmed.ncbi.nlm.nih.gov/19816759