The Shared Ethical Responsibility of Medically and Non-medically Qualified Experts in Human Drug Development Teams

Autor: Sandor Kerpel-Fronius, Sander Becker, Jane Barrett, Johan Brun, Roberto Carlesi, Anthony Chan, Luis F. Collia, Dominique J. Dubois, Peter Kleist, Greg Koski, Chieko Kurihara, Luis F. Laranjeira, Johanna Schenk, Honorio Silva

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

The complexity of developing and applying increasingly sophisticated new medicinal products has led to the participation of many non-medically qualified scientists in multi-disciplinary non-clinical and clinical drug development teams world-wide. In

Externí odkaz: https://doaj.org/article/ca3a8796f31a4ed4b674d0e11c3d82a5

HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

Autor: Milana A. Bergamino, Elena López-Knowles, Gabriele Morani, Holly Tovey, Lucy Kilburn, Eugene F. Schuster, Anastasia Alataki, Margaret Hills, Hui Xiao, Chris Holcombe, Anthony Skene, John F. Robertson, Ian E. Smith, Judith M. Bliss, Mitch Dowsett, Maggie C.U. Cheang, Abigail Evans, Adrian Ball, Akhil Johri, Ali Nejim, Alison Jones, Allan Corder, Amanda Thorne, Ambika Anand, Amitabha Chakrabarti, Anne Robinson, Anupam Modi, Ashraf Patel, Ashutosh Kothari, Brendan McFall, Caroline Mortimer, Caroline Lee, Charlie Chan, Charlotte Abson, Christopher Holcombe, Christopher Hinton, Ciaran Hollywood, Claire Murphy, Clare Crowley, Claudia Harding-Mackean, Clive Griffith, Conrad Lewanski, Daniel Rea, David Hwang, Derek Crawford, Dinesh Thekkinkattil, Douglas Ferguson, Douglas Adamson, Duncan Wheatley, Duraisamy Ravichandran, Ed Babu, Elaine Hyett, Fawzia Ashkanani, Fiona Hoar, Frances Kenny, Gary Dyke, Geoffrey Sparrow, null Gilbert, Giles Cunnick, Hafiz Algurafi, Helen Sweetland, Highes-Davies Prof, Hisham Hamed, Ian Smith, Ian Laidlaw, Ilyas Khattak, Jacqueline Newby, Jacqueline Rees-Lee, Jalal Kokan, Jane Barrett, Jay Dolatrai Naik, Jayant Vaidya, Jennifer Forrest, Jitendra Parmar, Jocelyn Adams, John Fox, Jonathan Roberts, Jonathan Dawson, Julie Doughty, Jull Donnelly, Kathleen Dunn, Kian Chin, Kieran Horgan, Kislaya Thakur, Ludger Barthelmes, Lynda Wyld, Madhumita Bhattacharyya, Maher Hadaki, Makam Kishore, Marcus Ornstein, Maria Bramley, Maria Bews-Hair, Marina Parton, Mark Sibbering, Mark Kissin, Mark Churn, Martin Hogg, Mary Quigley, Matthew Hatton, Matthew Winter, Matthew Adelekan, Michael Shere, Michael Carr, Michael Williams, Mohammed Absar, Muhammad Sharif, Muireann Kelleher, Nawaz Walji, Nicholas Williams, Nicholas Gallegos, Nigel Bundred, Olivia Hatcher, Perric Crellin, Peter Crane, Peter Donnelly, Peter Kneeshaw, Philip Walker, Prakash Sinha, Pudhupalayam Bhaskar, Racheal Soulsby, Radha Todd, Raghavan Vidya, Rakesh Mehra, Ramachandran Prasad, Ramsay Cutress, Ravi Sharma, Rebecca Roylance, Rebecca Goranova, Reem Ramzi Salman, Riccardo Bonom, Richard Johnson, Richard Sutton, Rick Linforth, Rob Coleman, Robert Grieve, Robert Leonard, Robert Reichert, Robert Kennedy, Roshan Agarwal, Rozenn Allerton, Russell Burcombe, Ruth Davis, Sankaran Narayanan, Sankaran Chandrasekharan, Sarah Vesty, Seema Seetharam, Serena Ledwidge, Shabana Iqbal, Shamaela Wahee, Shobha Silva, Simon Pain, Simon Holt, Simon Thomson, Simon Smith, Simon Ellenbogen, Siobhan Laws, Stephen Chan, Stephen Johnston, Steve Holt, Steven Thrush, Stuart McIntosh, Sumohan Chatterjee, Susan Cleator, Tamoor Usman, Tayo Johnson, Tibor Kovacs, Tracey Irvine, Urmila Barthkur, Vanessa Pope, Victoria Alexandra Brown, Vummiti Muralikrishna, Walid Samra, William Maxwell, Zoe Winters

Publikováno v: EBioMedicine. 83

Background: oestrogen receptor positive/ human epidermal growth factor receptor positive (ER+/HER2+) breast cancers (BCs) are less responsive to endocrine therapy than ER+/HER2- tumours. Mechanisms underpinning the differential behaviour of ER+HER2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c36f0affe9cade26299ca49ee96f2
https://pubmed.ncbi.nlm.nih.gov/35985932

The Shared Ethical Responsibility of Medically and Non-medically Qualified Experts in Human Drug Development Teams

Autor: Chieko Kurihara, David Dubois, Jane Barrett, Luís Filipe Laranjeira, Greg Koski, Luis Francisco Collia, Roberto Carlesi, Sandor Kerpel-Fronius, Anthony A.W. Chan, Peter Kleist, Honorio Silva, Johan Brun, Sander Becker, Johanna Schenk

Publikováno v: Frontiers in Pharmacology, 9 (SEP
Frontiers in Pharmacology, Vol 9 (2018)

The complexity of developing and applying increasingly sophisticated new medicinal products has led to the participation of many non-medically qualified scientists in multi-disciplinary non-clinical and clinical drug development teams world-wide. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60734b27dbb8168f2836eaad7f4c9dd1
https://doi.org/10.3389/fphar.2018.00843

An audit of cancer of unknown primary notifications: A cautionary tale for population health research using cancer registry data

Autor: Andrea L Schaffer, Jane Barrett, Chuang Ching Er, Claire M. Vajdic, Robyn L. Ward, Lucy Wyld, Nicola S. Meagher, Timothy Dobbins, Sallie-Anne Pearson

Publikováno v: Cancer Epidemiology. 38:460-464

Background: Cancer of unknown primary (CUP) is a common cancer yet little is known about the reliability of incidence data. Methods: We audited 574 CUP (C80.9) diagnoses (median age 81 years) registered by the New South Wales (NSW) Central Cancer Reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0866ef6c308a482db0d8853da9d30b7b
https://doi.org/10.1016/j.canep.2014.05.004

Prevention and Detection of Fraud in Clinical Trials

Autor: Jane Barrett

INTRODUCTION Fraud and misconduct in clinical research can be found wherever research takes place whether that research is academic or sponsored by the pharmaceutical industry. Numerically, however, most detected cases have been found in industry-spo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24a95dc959ce0c84c5bcb4531a567ce3
https://doi.org/10.3109/9781420081831-44