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Akademický článek

Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

Autor: Alex F Thompson, Patrick R Blackburn, Noah S Arons, Sarah N Stevens, Dusica Babovic-Vuksanovic, Jane B Lian, Eric W Klee, Jason Stumpff

Publikováno v: eLife, Vol 11 (2022)

The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the i

Externí odkaz: https://doaj.org/article/8723f0c9edc84db2b8e75bfe755aa234

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Akademický článek

Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells.

Autor: Terri L Messier, Joseph R Boyd, Jonathan A R Gordon, Coralee E Tye, Natalie A Page, Rabail H Toor, Sayyed K Zaidi, Barry S Komm, Seth Frietze, Janet L Stein, Jane B Lian, Gary S Stein

Publikováno v: PLoS ONE, Vol 17, Iss 7, p e0271725 (2022)

Selective estrogen receptor modulators (SERMs), including the SERM/SERD bazedoxifene (BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) risk. One of the most persistent unresolved questions regarding menopausal ho

Externí odkaz: https://doaj.org/article/23747e72e03144299f6791559e911b97

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Akademický článek

Genome-wide DNase hypersensitivity, and occupancy of RUNX2 and CTCF reveal a highly dynamic gene regulome during MC3T3 pre-osteoblast differentiation.

Autor: Phillip W L Tai, Hai Wu, André J van Wijnen, Gary S Stein, Janet L Stein, Jane B Lian

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188056 (2017)

The ability to discover regulatory sequences that control bone-related genes during development has been greatly improved by massively parallel sequencing methodologies. To expand our understanding of cis-regulatory regions critical to the control of

Externí odkaz: https://doaj.org/article/85178e64e02d4c448fb22b597120e206

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Akademický článek

TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts.

Autor: John R Hawse, Muzaffer Cicek, Sarah B Grygo, Elizabeth S Bruinsma, Nalini M Rajamannan, Andre J van Wijnen, Jane B Lian, Gary S Stein, Merry Jo Oursler, Malayannan Subramaniam, Thomas C Spelsberg

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e19429 (2011)

Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals. Calvarial osteoblasts isolated from TIEG1 knockout (K

Externí odkaz: https://doaj.org/article/c3b2d29944cd4ce390182c32fdb11d6f

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Akademický článek

LncMIR181A1HG is a novel chromatin-bound epigenetic suppressor of early stage osteogenic lineage commitment

Autor: Coralee E. Tye, Prachi N. Ghule, Jonathan A. R. Gordon, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Kirsten M. Tracy, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Bone formation requires osteogenic differentiation of multipotent mesenchymal stromal cells (MSCs) and lineage progression of committed osteoblast precursors. Osteogenic phenotype commitment is epigenetically controlled by genomic (chromatin

Externí odkaz: https://doaj.org/article/cb869d076f7b42c0a921afee30acdf08

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