Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Jane Alder"'
1
Structure-Based Design of Potent Selective Nanomolar Type-II Inhibitors of Glycogen Synthase Kinase-3β
Autor: Philip J. Welsby, Concepción Pérez, Rocio Benitez, Matthew P. Davies, Sven Jakupovic, Klaudia Magdalena Rzepecka, Jane Alder, Ana Martínez, Colin Davidson, Joseph Hayes
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
For the first time, the in silico design, screening, and in vitro validation of potent GSK-3β type-II inhibitors are presented. In the absence of crystallographic evidence for a DFG-out GSK-3β activation loop conformation, computational models were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffe78ae031a6e5ae4275a14b1e4937e
http://hdl.handle.net/10261/261557
Zobrazit plný text záznamu
2
Raman hyperspectral imaging coupled to three-dimensional discriminant analysis: Classification of meningiomas brain tumour grades
Autor: Taha Lilo, Camilo L.M. Morais, Katherine M. Ashton, Charles Davis, Timothy P. Dawson, Francis L. Martin, Jane Alder, Gareth Roberts, Arup Ray, Nihal Gurusinghe
Publikováno v: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 273:121018
Meningiomas remains a clinical dilemma. They are the commonest "benign" types of brain tumours and, although being typically benign, they are divided into three WHO grades categories (I, II and III) which are associated with the tumour growth rate an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86533bca506a7fd8a44c230d27e230d0
https://doi.org/10.1016/j.saa.2022.121018
Zobrazit plný text záznamu
3
Tailoring functional nanostructured lipid carriers for glioblastoma treatment with enhanced permeability through in-vitro 3D BBB/BBTB models
Autor: Tamara Zwain, Andrew Shaw, Kamalinder K. Singh, Andrea Julie Burrow, Jane Alder, Bassem Sabagh
Publikováno v: Materials scienceengineering. C, Materials for biological applications. 121
The blood-brain barrier (BBB) and blood-brain tumour barrier (BBTB) pose a significant challenge to drug delivery to brain tumours, including aggressive glioblastoma (GB). The present study rationally designed functional nanostructured lipid carriers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0e2f0b1f0ca33250b4c6059b931740
https://pubmed.ncbi.nlm.nih.gov/33579439
Zobrazit plný text záznamu
4
A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells
Autor: Carla Lucia Esposito, Roberto Pallini, Clare Louise Lawrence, Silvia Nuzzo, Vittorio de Franciscis, Swati A. Kumar, Lucia Ricci-Vitiani, Jane Alder, Lisa Shaw, Anna Rienzo, Silvia Catuogno
Publikováno v: Journal of controlled release 238 (2016): 43–57. doi:10.1016/j.jconrel.2016.07.032
info:cnr-pdr/source/autori:Esposito, Carla L.; Nuzzo, Silvia; Kumar, Swati A.; Rienzo, Anna; Lawrence, Clare L.; Pallini, Roberto; Shaw, Lisa; Alder, Jane E.; Ricci-Vitiani, Lucia; Catuogno, Silvia; de Franciscis, Vittorio/titolo:A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells/doi:10.1016%2Fj.jconrel.2016.07.032/rivista:Journal of controlled release/anno:2016/pagina_da:43/pagina_a:57/intervallo_pagine:43–57/volume:238
A minor population of glioblastoma stem-like cells (GSCs) has been implicated in the relapse and resistance of glioblastoma to therapeutic treatments. Based on knowledge of the involvement of multiple microRNAs in GSC propagation, we designed a combi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e7eb769d95eae2b4a9fdcd5343303b
https://doi.org/10.1016/j.jconrel.2016.07.032
Zobrazit plný text záznamu
5
The identification and validation of novel aptamers for the diagnosis of oligodendroglioma
Autor: Jane Alder, Catherine Coxon, Lisa Shaw, Clare Louise Lawrence
Oligodendroglioma account for nearly 12% of brain tumours (Jain et al., 2017). In the United Kingdom, 0.4 people per 100 000 per year are newly diagnosed with oligodendroglioma (Crocetti et al., 2012). Early diagnosis and treatment of oligodendroglio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249470cca68ec79721779ab9b8d499e1
https://europepmc.org/articles/PMC5791674/
Zobrazit plný text záznamu
6
Folate: Friend or Foe? An investigation into the opposing roles of folate in glioma
Autor: Robert W. Lea, Michelle Claire Rudd, Jane Alder
For individuals diagnosed with a glioma, survival rates have shown little improvement over the last 40 years due to the heterogeneity of tumours and the difficulty of specifically targeting the tumour whilst sparing surrounding healthy tissue. Altere
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112bb62688a3d29576e2e6e2ce12f06d
https://europepmc.org/articles/PMC5791709/
Zobrazit plný text záznamu
7
Selective Targeting to Glioma with Nucleic Acid Aptamers
Autor: Lisa Shaw, Robert W. Lea, Shraddha Aptekar, Timothy Dawson, Katherine M. Ashton, Mohit Arora, Clare Louise Lawrence, Jane Alder
Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134957 (2015)
PLoS ONE
Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis and treatment is difficult and patient survival is poor. Aptamers contribute a promising and unique tec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19a770a64448cd3a4907793c4feb98e
https://doaj.org/article/d5a2cfd38ea24e51bb014a99a0cdda93
Zobrazit plný text záznamu
9
P41IDENTIFICATION OF GLIOMA SPECIFIC APTAMER TARGETS
Autor: Charles Davis, Jane Alder, Mohit Arora, Timothy Dawson, Clare Louise Lawrence, Greg Hall, Lisa Shaw
INTRODUCTION: Aptamers are in vitro generated DNA and RNA sequences which are randomly created as a library, with multiple permutations and combinations. These are then exposed to the target structure against which we want an aptamer ‘selected’ u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b108c2986d7eff4c8f337489ecec9ed2
https://europepmc.org/articles/PMC4200909/
Zobrazit plný text záznamu
10
P47THE IDENTIFICATION OF NOVEL APTAMERS TO GLIOMA
Autor: Lisa Shaw, Jane Alder, Karl Norris, Clare Louise Lawrence
INTRODUCTION: Glioma represent less than 2% of all cancer cases in the UK, however, 80% of these tumours are glioblastoma (GBM). GBM is a highly aggressive tumour with poor patient survival rates, despite treatment involving surgery and radiotherapy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed20488732bae9b97b0855be0394cb0
https://europepmc.org/articles/PMC4200914/
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje