Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jane A. Wakeman"'
Publikováno v:
Experimental Results, Vol 1 (2020)
Chordoma is a rare bone cancer for which there are no approved drugs. Surgery is the principle treatment but complete resection can be challenging due to the location of the tumours in the spine and therefore finding an effective drug treatment is a
Externí odkaz:
https://doaj.org/article/eb286dba64824fab93a36ee85ecb8e20
Autor:
Vicente Planells-Palop, Ali Hazazi, Julia Feichtinger, Jana Jezkova, Gerhard Thallinger, Naif O. Alsiwiehri, Mikhlid Almutairi, Lee Parry, Jane A. Wakeman, Ramsay J. McFarlane
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-18 (2017)
Abstract Background Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that t
Externí odkaz:
https://doaj.org/article/173a926d7ccd41439322b850a8a214a4
Autor:
Natalia Gomez-Escobar, Ahad A A Alsaiari, Hanadi A S Alahamadi, Othman Alzahrani, Ellen Vernon, Hussam A E Althagafi, Nasser S Almobadel, David W Pryce, Jane A Wakeman, Ramsay J McFarlane
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010267 (2022)
The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder of cancer-associated chromosomal translocation breakpoint junctions leading to the sugge
Externí odkaz:
https://doaj.org/article/0d9ad75f05fd4a4dba7235dd3ca3a650
Autor:
Jane A. Wakeman, Ramsay J. McFarlane
Publikováno v:
Trends in Cancer. 6:450-453
Dicer-deficient cancers have poor prognoses, which is linked to the degradation of tumour-suppressing miRNA precursors by the Translin-Trax (Tn-Tx) ribonuclease. Inhibition of Tn-Tx potentially offers a new therapeutic intervention point. However, Tn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae60207551120186809071b1aba560e
https://doi.org/10.1016/j.trecan.2020.02.014
https://doi.org/10.1016/j.trecan.2020.02.014
Publikováno v:
Trends in Cancer. 6:271-273
New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86372d374445650258bcf4e3c310222c
https://doi.org/10.1016/j.trecan.2020.01.014
https://doi.org/10.1016/j.trecan.2020.01.014
All-trans retinoic acid (ATRA) reduces proliferative capacity and Brachyury levels in chordoma cells
Chordoma is a rare bone cancer for which there are no approved drugs. Surgery is the principle treatment but complete resection can be challenging due to the location of the tumours in the spine and therefore finding an effective drug treatment is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb9b247fce9b75e487ccbda305e299a
Publikováno v:
Experimental Results. 1
Chordoma is a rare bone cancer for which there are no approved drugs. Surgery is the principle treatment but complete resection can be challenging due to the location of the tumours in the spine and therefore finding an effective drug treatment is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f45dc33186e09f50451f68ce2c387a
https://doi.org/10.1017/exp.2020.31
https://doi.org/10.1017/exp.2020.31
Autor:
Ramsay J. McFarlane, Jane A. Wakeman
Publikováno v:
Cancer Research. 77:5712-5716
Cancer cells have many abnormal characteristics enabling tumors to grow, spread, and avoid immunologic and therapeutic destruction. Central to this is the innate ability of populations of cancer cells to rapidly evolve. One feature of many cancers is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9895448287ce9b6f2d3caf5345df4d
https://doi.org/10.1158/0008-5472.can-17-1535
https://doi.org/10.1158/0008-5472.can-17-1535
Autor:
Gerhard G. Thallinger, Ramsay J. McFarlane, Jane A. Wakeman, Ali Hazazi, Julia Feichtinger, Naif O. Alsiwiehri, Jana Jezkova, Lee Parry, Vicente Planells-Palop, Mikhlid Almutairi
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-18 (2017)
Molecular Cancer
Molecular Cancer
Background Cancer/testis (CT) genes have expression normally restricted to the testis, but become activated during oncogenesis, so they have excellent potential as cancer-specific biomarkers. Evidence is starting to emerge to indicate that they also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36166e9294c8a1a3b59064cb3096d01
http://link.springer.com/article/10.1186/s12943-017-0653-4
http://link.springer.com/article/10.1186/s12943-017-0653-4
Autor:
Gerhard G. Thallinger, Nasser Almobadel, Natalia Gomez-Escobar, Othman Alzahrani, Vicente Planells-Palop, Julia Feichtinger, Jane A. Wakeman, Ramsay J. McFarlane, Zafer Saad Alshehri
Publikováno v:
Oncotarget
// Natalia Gomez-Escobar 1,* , Nasser Almobadel 1,* , Othman Alzahrani 1,* , Julia Feichtinger 2,3,* , Vicente Planells-Palop 1,* , Zafer Alshehri 1 , Gerhard G. Thallinger 2,3 , Jane A. Wakeman 1 and Ramsay J. McFarlane 1 1 North West Cancer Researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70ffd6af6e780cc5dca098149c3d995
https://doi.org/10.18632/oncotarget.9278
https://doi.org/10.18632/oncotarget.9278