Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Jane A. Plumb"'
Publikováno v:
Journal of Inorganic Biochemistry. 128:124-130
The sgc8c aptamer is a 41-base DNA oligonucleotide that binds to leukaemia cells with high affinity and specificity. In this work we examined the utility of this aptamer as both a delivery vehicle and an active targeting agent for an inert platinum c
Autor:
Jane A. Plumb, Wojciech Chrzanowski, Sarah D. Brown, Roisin E. Brown, Norbert Schreiter, Amelia J. Wagstaff, Gemma E. Craig, Nial J. Wheate, Megan R. Holden
Publikováno v:
Inorganica Chimica Acta. 393:328-333
The platinum-based chemotherapeutic drug cisplatin is highly effective in the treatment of solid tumours, but its use is restricted by poor bioavailability, severe dose-limiting side effects and rapid development of drug resistance. In light of this
Autor:
Nicola Steele, Andrew Walley, Wei Dai, S. Rizzo, A. van der Zee, Afshan Siddiq, Robert S. Brown, Constanze Zeller, Jane A. Plumb, Charlotte Wilhelm-Benartzi
Publikováno v:
ONCOGENE, 31(42), 4567-4576. Nature Publishing Group
Multiple DNA methylation changes in the cancer methylome are associated with the acquisition of drug resistance; however it remains uncertain how many represent critical DNA methylation drivers of chemoresistance. Using isogenic, cisplatin-sensitive/
Publikováno v:
British Journal of Cancer
Histone deacetylation and DNA methylation have a central role in the control of gene expression in tumours, including transcriptional repression of tumour suppressor genes and genes involved in sensitivity to chemotherapy. Treatment of cisplatin-resi
Autor:
Michele Lieb, Hinrich Gronemeyer, Robert S. Brown, Mirjam T. Epping, René Bernards, Liming Wang, Jane A. Plumb
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104 (45), pp.17777-82. ⟨10.1073/pnas.0702518104⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104 (45), pp.17777-82. ⟨10.1073/pnas.0702518104⟩
Understanding the pathways that are targeted by cancer drugs is instrumental for their rational use in a clinical setting. Inhibitors of histone deacetylases (HDACI) selectively inhibit proliferation of malignant cells and are used for the treatment
Autor:
Paul Workman, Jane A. Plumb
Publikováno v:
International Journal of Cancer. 56:134-139
Studies with purified DT-diaphorase have shown that the enzyme is capable of catalyzing a two-electron reduction of the novel indoloquinone E09 to a DNA-damaging alkylating species. The aim of this study was to determine to what extent DT-diaphorase
Publikováno v:
Journal of Ovarian Research
Background Ovarian cancer is the most fatal of gynaecological malignancies, usually detected at a late stage with intraperitoneal dissemination. Appropriate preclinical models are needed that recapitulate both the histopathological and molecular feat
Autor:
Paul J. Smith, Laurence Hylton Patterson, Jane A. Plumb, Robert S. Brown, Paul H. Teesdale-Spittle, Klaus Pors, Mark Searcey
Publikováno v:
Journal of Medicinal Chemistry. 48:6690-6695
A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkylamino side chains. One aminoanthraquinone (13) was further derivat
Autor:
Robert S. Brown, Manel Esteller, Peter A. Dervan, Alison A. Murphy, Edward J. Fox, William M. Gallagher, Ilse-Maria Nolan, Orla Bergin, Fiona O'Mahony, David J. Easty, Linda Hughes, Raymond L. Stallings, Aedín C. Culhane, Mario F. Fraga, Susan McDonnell, Jane A. Plumb, L. McArdle, Mairin Rafferty, Aileen Byrne, Caroline A. Currid, Zoe D. Kelly, Catherine Moss
Publikováno v:
Carcinogenesis. 26:1856-1867
The incidence of melanoma is increasing rapidly, with advanced lesions generally failing to respond to conventional chemotherapy. Here, we utilized DNA microarray-based gene expression profiling techniques to identify molecular determinants of melano
Autor:
David J. Kerr, Matthew N. Hodgkin, Graeme MacAully, Jane A. Plumb, Michael J.O. Wakelam, Michael J. Cross, Allison Stewart, Paul Workman, Valerie G. Brunton, Robert A. Hill
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1362(1):29-38
Growth factors and certain oncogenes activate a range of phospholipid-mediated signal transduction pathways resulting in cell proliferation. Demethoxyviridin (DMV), a structural analogue of wortmannin and recently reported as a potent inhibitor of ph