Zobrazeno 1 - 10
of 385
pro vyhledávání: '"Jane A. Mckeating"'
Autor:
Atish Mukherji, Frank Jühling, Yogy Simanjuntak, Emilie Crouchet, Fabio Del Zompo, Yuji Teraoka, Alexandre Haller, Philippe Baltzinger, Soumith Paritala, Fahmida Rasha, Naoto Fujiwara, Cloé Gadenne, Nevena Slovic, Marine A. Oudot, Sarah C. Durand, Clara Ponsolles, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Ming-Lun Yeh, Hiromi Abe-Chayama, Mathias Heikenwälder, Angelo Sangiovanni, Massimo Iavarone, Massimo Colombo, Steven K. H. Foung, Jane A. McKeating, Irwin Davidson, Ming-Lung Yu, Raymond T. Chung, Yujin Hoshida, Kazuaki Chayama, Joachim Lupberger, Thomas F. Baumert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the identity and epigenetic regulation of rhythmically exp
Externí odkaz:
https://doaj.org/article/faee0116ddb14568af297762b93cc7d2
Autor:
Upkar S Gill, Patrick T F Kennedy, Andrew Hall, Rageshri Dhairyawan, Alberto Quaglia, James M Harris, Colin Nixon, Fadi Issa, Amy Cross, Edward Arbe-Barnes, Jane A McKeating, Dimitra Peppa
Publikováno v:
eGastroenterology, Vol 2, Iss 3 (2024)
Background and aims The intrahepatic processes associated with chronic hepatitis B (CHB), especially in the context of hepatitis delta virus (HDV) and HIV co-infection, require a better understanding. Spatial transcriptomics can provide new insights
Externí odkaz:
https://doaj.org/article/fc1ee0e355574540accc5e4589a7d9e0
Autor:
Senko Tsukuda, James M Harris, Andrea Magri, Peter Balfe, Aleem Siddiqui, Peter A C Wing, Jane A McKeating
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011917 (2024)
Chronic hepatitis B is a global health problem and current treatments only suppress hepatitis B virus (HBV) infection, highlighting the need for new curative treatments. Oxygen levels influence HBV replication and we previously reported that hypoxia
Externí odkaz:
https://doaj.org/article/4b1aa3e102fc4e3c95dc5a03913a0d01
Autor:
Xiaodong Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James M. Harris, Senko Tsukuda, Eleanor Bentley, Adam Kirby, Simon de Neck, Hongbing Yang, Peter Balfe, Peter A.C. Wing, David Matthews, Adrian L. Harris, Anja Kipar, James P. Stewart, Dalan Bailey, Jane A. McKeating
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108763- (2024)
Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limi
Externí odkaz:
https://doaj.org/article/52733874b25843c39f1dfa58054f20fe
Autor:
Helene Borrmann, Görkem Ulkar, Anna E. Kliszczak, Dini Ismed, Mirjam Schilling, Andrea Magri, James M. Harris, Peter Balfe, Sridhar Vasudevan, Persephone Borrow, Xiaodong Zhuang, Jane A. McKeating
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107007- (2023)
Summary: Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism’s response to its environment and
Externí odkaz:
https://doaj.org/article/5f956c81ca754f56adc211d1c7804d32
Autor:
Peter A C Wing, Nathalie M Schmidt, Rory Peters, Maximilian Erdmann, Rachel Brown, Hao Wang, Leo Swadling, COVIDsortium Investigators, Joseph Newman, Nazia Thakur, Kaho Shionoya, Sophie B Morgan, Timothy Sc Hinks, Koichi Watashi, Dalan Bailey, Scott B Hansen, Andrew D Davidson, Mala K Maini, Jane A McKeating
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011323 (2023)
The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for ch
Externí odkaz:
https://doaj.org/article/e445203a65eb44e382330b64fd988f25
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Autor:
Lewis Taylor, Felix Von Lendenfeld, Anna Ashton, Harshmeena Sanghani, Simona Di Pretoro, Laura Usselmann, Maria Veretennikova, Robert Dallmann, Jane A. McKeating, Sridhar Vasudevan, Aarti Jagannath
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105877- (2023)
Summary: Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection follow
Externí odkaz:
https://doaj.org/article/a1abe26ff9904b94aa701cbd4db3ba41
Autor:
Peter A C Wing, Maria Prange-Barczynska, Amy Cross, Stefania Crotta, Claudia Orbegozo Rubio, Xiaotong Cheng, James M Harris, Xiaodong Zhuang, Rachel L Johnson, Kathryn A Ryan, Yper Hall, Miles W Carroll, Fadi Issa, Peter Balfe, Andreas Wack, Tammie Bishop, Francisco J Salguero, Jane A McKeating
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010807 (2022)
Understanding the host pathways that define susceptibility to Severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define the transcrip
Externí odkaz:
https://doaj.org/article/3c410b7e7d0e4ff392b4c3a2e70b9525
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Autor:
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses
Externí odkaz:
https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
Autor:
Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D’Arienzo, Laurent Mailly, James M. Harris, Peter A. C. Wing, Helene Borrmann, Mirjam Schilling, Andrea Magri, Claudia Orbegozo Rubio, Robert J. Maidstone, Mudassar Iqbal, Miguel Garzon, Rosalba Minisini, Mario Pirisi, Sam Butterworth, Peter Balfe, David W. Ray, Koichi Watashi, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 d
Externí odkaz:
https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8