Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Jane A. McKeating"'
Autor:
Xiaodong Zhuang, Giulia Gallo, Parul Sharma, Jiyeon Ha, Andrea Magri, Helene Borrmann, James M. Harris, Senko Tsukuda, Eleanor Bentley, Adam Kirby, Simon de Neck, Hongbing Yang, Peter Balfe, Peter A.C. Wing, David Matthews, Adrian L. Harris, Anja Kipar, James P. Stewart, Dalan Bailey, Jane A. McKeating
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108763- (2024)
Summary: Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness in young children and elderly individuals. Our knowledge of the host pathways that define susceptibility to infection and disease severity are limi
Externí odkaz:
https://doaj.org/article/52733874b25843c39f1dfa58054f20fe
Autor:
Helene Borrmann, Görkem Ulkar, Anna E. Kliszczak, Dini Ismed, Mirjam Schilling, Andrea Magri, James M. Harris, Peter Balfe, Sridhar Vasudevan, Persephone Borrow, Xiaodong Zhuang, Jane A. McKeating
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107007- (2023)
Summary: Human immunodeficiency virus 1 (HIV-1) causes major health burdens worldwide and still lacks curative therapies and vaccines. Circadian rhythms are endogenous daily oscillations that coordinate an organism’s response to its environment and
Externí odkaz:
https://doaj.org/article/5f956c81ca754f56adc211d1c7804d32
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Autor:
Lewis Taylor, Felix Von Lendenfeld, Anna Ashton, Harshmeena Sanghani, Simona Di Pretoro, Laura Usselmann, Maria Veretennikova, Robert Dallmann, Jane A. McKeating, Sridhar Vasudevan, Aarti Jagannath
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105877- (2023)
Summary: Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection follow
Externí odkaz:
https://doaj.org/article/a1abe26ff9904b94aa701cbd4db3ba41
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Autor:
Nathalie M. Schmidt, Peter A. C. Wing, Mariana O. Diniz, Laura J. Pallett, Leo Swadling, James M. Harris, Alice R. Burton, Anna Jeffery-Smith, Nekisa Zakeri, Oliver E. Amin, Stephanie Kucykowicz, Mirjam H. Heemskerk, Brian Davidson, Tim Meyer, Joe Grove, Hans J. Stauss, Ines Pineda-Torra, Clare Jolly, Elizabeth C. Jury, Jane A. McKeating, Mala K. Maini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Shared metabolic pathways could allow simultaneous manipulation of T cells, viruses and tumours. Here the authors show targeting cholesterol esterification restrains hepatitis B in vitro, whilst bolstering exhausted antigen-specific T cell responses
Externí odkaz:
https://doaj.org/article/80c091a62a0e452aadda8e67b452162c
Autor:
Xiaodong Zhuang, Donall Forde, Senko Tsukuda, Valentina D’Arienzo, Laurent Mailly, James M. Harris, Peter A. C. Wing, Helene Borrmann, Mirjam Schilling, Andrea Magri, Claudia Orbegozo Rubio, Robert J. Maidstone, Mudassar Iqbal, Miguel Garzon, Rosalba Minisini, Mario Pirisi, Sam Butterworth, Peter Balfe, David W. Ray, Koichi Watashi, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al. show that REV-ERB regulates hepatitis B virus entry and BMAL1 d
Externí odkaz:
https://doaj.org/article/6a8ef38d436d4d3fbb7a5a30aa9a40f8
Autor:
Lindsay G. A. McKay, Jordan Thomas, Wejdan Albalawi, Antoine Fattaccioli, Marc Dieu, Alessandra Ruggiero, Jane A. McKeating, Jonathan K. Ball, Alexander W. Tarr, Patricia Renard, Georgios Pollakis, William A. Paxton
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Following acute HCV infection, the virus establishes a chronic disease in the majority of patients whilst few individuals clear the infection spontaneously. The precise mechanisms that determine chronic HCV infection or spontaneous clearance are not
Externí odkaz:
https://doaj.org/article/f92175559e4d475f92e4cd98ff8fb59a
Autor:
Yibin Liu, Jingfei Cheng, Paulina Siejka-Zielińska, Carika Weldon, Hannah Roberts, Maria Lopopolo, Andrea Magri, Valentina D’Arienzo, James M. Harris, Jane A. McKeating, Chun-Xiao Song
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract We present long-read Tet-assisted pyridine borane sequencing (lrTAPS) for targeted base-resolution sequencing of DNA methylation and hydroxymethylation in regions up to 10 kb from nanogram-level input. Compatible with both Oxford Nanopore an
Externí odkaz:
https://doaj.org/article/51a16a1b45b7443391655c421790aeea
Autor:
Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103144- (2021)
Summary: The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the re
Externí odkaz:
https://doaj.org/article/9e863295d0ed4df8a498ce0d3e971ee4
Autor:
Xiaodong Zhuang, Wei Wang, Helene Borrmann, Peter Balfe, Philippa C. Matthews, David W. Eyre, Elizabeth B. Klerman, Jane A. McKeating
Publikováno v:
Viruses, Vol 14, Iss 8, p 1728 (2022)
Circadian rhythms influence and coordinate an organism’s response to its environment and to invading pathogens. We studied the diurnal variation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasal/throat swabs collected in
Externí odkaz:
https://doaj.org/article/5af2de907b2b406280a36761accf3a4f
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
Autor:
Peter A.C. Wing, Thomas P. Keeley, Xiaodong Zhuang, Jeffrey Y. Lee, Maria Prange-Barczynska, Senko Tsukuda, Sophie B. Morgan, Adam C. Harding, Isobel L.A. Argles, Samvid Kurlekar, Marko Noerenberg, Craig P. Thompson, Kuan-Ying A. Huang, Peter Balfe, Koichi Watashi, Alfredo Castello, Timothy S.C. Hinks, William James, Peter J. Ratcliffe, Ilan Davis, Emma J. Hodson, Tammie Bishop, Jane A. McKeating
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109020- (2021)
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension,
Externí odkaz:
https://doaj.org/article/0e81e8390d8b4bff8a888f023b7b0038