Zobrazeno 1 - 10 of 77 pro vyhledávání: '"Jane A. Goodall"'
1
Akademický článek
Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling
Autor: Matthew J. Elder, Steve J. Webster, Timothy J. Fitzmaurice, Aran S. D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases. TSLP is produced by many cell types, but has predominantly been characterized as a
Externí odkaz: https://doaj.org/article/d37c0112f5e9441b8aa4a1a774e80bea
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2
Akademický článek
β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production
Autor: Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall
Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immuni
Externí odkaz: https://doaj.org/article/7b61fa02b4424390890f997b33134bad
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3
Akademický článek
Detection of a microbial metabolite by STING regulates inflammasome activation in response to Chlamydia trachomatis infection.
Autor: Steve J Webster, Sven Brode, Lou Ellis, Timothy J Fitzmaurice, Matthew J Elder, Nelson O Gekara, Panagiotis Tourlomousis, Clare Bryant, Simon Clare, Ronnie Chee, Hill J S Gaston, Jane C Goodall
Publikováno v: PLoS Pathogens, Vol 13, Iss 6, p e1006383 (2017)
The innate immune system is a critical component of host defence against microbial pathogens, but effective responses require an ability to distinguish between infectious and non-infectious insult to prevent inappropriate inflammation. Using the impo
Externí odkaz: https://doaj.org/article/cc7ab21c35704bf99075bec68f1688a5
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6
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress
Autor: Bradly G. Wouters, Elisa Laurenti, Peter van Galen, Nathan Mbong, Tim J. Fitzmaurice, Erno Wienholds, Karin G. Hermans, John E. Dick, Antonija Kreso, Joseph E. Chambers, Jane C. Goodall, Stephanie Z. Xie, David G. Kent, Stefan J. Marciniak, Anthony R. Green, Kolja Eppert
The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived due to their capacity for self-renewal. A consequence of longevity is exposure to stress stimuli including reactive oxygen species (ROS), nutrient fluctua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981e365b2d05641ae55c7b072eabcfaf
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7
TCR usage, gene expression and function of two distinct FOXP3 + Treg subsets within CD4 + CD25 hi T cells identified by expression of CD39 and CD45RO
Autor: Dmitriy M. Chudakov, Lei Jiang, Ekaterina V. Putintseva, Hill Gaston, Ting Li, Libin Zhang, Lingying Ye, Huji Xu, Giles S.H. Yeo, Li Lin, Jian Yin, Mikhail Shugay, Brian Y.H. Lam, Wei Liu, Xin Wu, Jane C. Goodall
Publikováno v: Immunology & Cell Biology. 94:293-305
FOXP3+ regulatory T (Treg) cells are indispensable for immune homeostasis, but their study in humans is complicated by heterogeneity within Treg, the difficulty in purifying Tregs using surface marker expression (e.g. CD25) and the transient expressi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4413e5d95da12d3b5af88043a682862
https://doi.org/10.1038/icb.2015.90
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8
TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils
Autor: Karsten Skjødt, Valeria Radjabova, Edwin R. Chilvers, Alexander D. Barrow, Bernard de Bono, Jane C. Goodall, Jatinder K. Juss, Des C. Jones, Piero Mastroeni, John Trowsdale, Paola Zaccone
Publikováno v: Radjabova, V, Mastroeni, P, Skjødt, K, Zaccone, P, de Bono, B, Goodall, J C, Chilvers, E R, Juss, J K, Jones, D C, Trowsdale, J & Barrow, A D 2015, ' TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils ', Journal of Immunology, vol. 195, no. 7, pp. 3149-3159 . https://doi.org/10.4049/jimmunol.1401847
We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell–interacting, activating receptor on myeloid cells-1 (TARM1). The transmembrane regi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e88727cb8071758fe749f3ff5fa744
https://doi.org/10.4049/jimmunol.1401847
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9
New concepts in Chlamydia induced inflammasome responses
Autor: Jane C. Goodall, Steve J. Webster
Publikováno v: Microbes and infection. 20(7-8)
Since the concept of the inflammasome was introduced by Martinon, Burns and Tschopp in 2002, there has been an exponential increase in our understanding of how inflammasomes (caspase activating molecular platforms) regulate innate inflammatory respon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f21668a255af335954daef2cef86e1
https://pubmed.ncbi.nlm.nih.gov/29248634
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