Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jane A. Endicott"'
Autor:
Rhianna J. Rowland, Svitlana Korolchuk, Marco Salamina, Natalie J. Tatum, James R. Ault, Sam Hart, Johan P. Turkenburg, James N. Blaza, Martin E. M. Noble, Jane A. Endicott
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we present the cryo-EM structure of CDK2-cycli
Externí odkaz:
https://doaj.org/article/7f9036edb0fb4c63978dfd51fe5e5873
Autor:
Rhianna J. Rowland, Richard Heath, Daniel Maskell, Rebecca F. Thompson, Neil A. Ranson, James N. Blaza, Jane A. Endicott, Martin E. M. Noble, Marco Salamina
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract p27KIP1 (cyclin-dependent kinase inhibitor 1B, p27) is a member of the CIP/KIP family of CDK (cyclin dependent kinase) regulators that inhibit cell cycle CDKs. p27 phosphorylation by CDK1/2, signals its recruitment to the SCFSKP2 (S-phase ki
Externí odkaz:
https://doaj.org/article/255a782ee4174ccbb388f8fffc48d107
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112139- (2023)
Summary: Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear. Using a fixed cell kinase assay and phosphoproteomics, we show how CDK1 activity and
Externí odkaz:
https://doaj.org/article/2111334f555d437b8f423cf5d6bf87ff
Autor:
Stephen T. Hallett, Martyna W. Pastok, R. Marc L. Morgan, Anita Wittner, Katie L.I.M. Blundell, Ildiko Felletar, Stephen R. Wedge, Chrisostomos Prodromou, Martin E.M. Noble, Laurence H. Pearl, Jane A. Endicott
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1386-1398 (2017)
Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system. Like other Hsp90
Externí odkaz:
https://doaj.org/article/47f3367cf8e14eb7a9f180a5866f49b6
Autor:
Daniel J. Wood, Jane A. Endicott
Publikováno v:
Open Biology, Vol 8, Iss 9 (2018)
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcription, metabo
Externí odkaz:
https://doaj.org/article/78283468c0b240b89b8dd3b1bbb950bc
Publikováno v:
RSC Chemical Biology. 4:146-164
This review summarises recent developments in structural characterisation of CDKs and alternative non-ATP competitive ways to inhibit them.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68d70fab0232ecbe9da59129ea88a4d
https://doi.org/10.1039/d2cb00201a
https://doi.org/10.1039/d2cb00201a
Autor:
Gemma Davison, Mathew P. Martin, Shannon Turberville, Selma Dormen, Richard Heath, Amy B. Heptinstall, Marie Lawson, Duncan C. Miller, Yi Min Ng, James N. Sanderson, Ian Hope, Daniel J. Wood, Céline Cano, Jane A. Endicott, Ian R. Hardcastle, Martin E. M. Noble, Michael J. Waring
Publikováno v:
Journal of Medicinal Chemistry. 65:15416-15432
The development of ligands for biological targets is critically dependent on the identification of sites on proteins that bind molecules with high affinity. A set of compounds, called FragLites, can identify such sites, along with the interactions re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5f45f4a2b13dc353a06e52583b772
https://doi.org/10.1021/acs.jmedchem.2c01357
https://doi.org/10.1021/acs.jmedchem.2c01357
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). Meriolins represent a chemical structural hybrid between meridianins and variolins, two familie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862a2f4d144630c783bf14488d81f62d
https://doi.org/10.1158/0008-5472.c.6495774.v1
https://doi.org/10.1158/0008-5472.c.6495774.v1
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Supplementary Figure 4 from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3970f1381a1112fc3eac3f8d94c493
https://doi.org/10.1158/0008-5472.22368006
https://doi.org/10.1158/0008-5472.22368006
Autor:
Laurent Meijer, Vicente Notario, Jane A. Endicott, Aude Echalier, Benoît Joseph, Bernard Marquet, François Liger, Michael H.G. Kubbutat, Christoph Schächtele, Peter Drueckes, Silvia Mateo-Lozano, Jonathan C. Morris, Olivier Lozach, Yoan Ferandin, Séverine Marionneau-Lambot, Oscar M. Tirado, Karima Bettayeb
Methods and Materials, Figure 4 Legend from Meriolins, a New Class of Cell Death–Inducing Kinase Inhibitors with Enhanced Selectivity for Cyclin-Dependent Kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518409c14552a25e83b2c37283b71aa5
https://doi.org/10.1158/0008-5472.22368009
https://doi.org/10.1158/0008-5472.22368009