Zobrazeno 1 - 10
of 344
pro vyhledávání: '"Jane A Mitchell"'
Autor:
R Gisli Jenkins, A John Simpson, Nicholas D Weatherley, Guilhem Collier, Jim M Wild, David R Thickett, Shaney L Barratt, Nazia Chaudhuri, Ling-Pei Ho, Lisa G Spencer, John F Blaikley, Fasihul Khan, Iain Stewart, John Kenneth Baillie, Rod Lawson, Simon R Johnson, Paul Beirne, Mark Spears, Laura Fabbri, Joseph Jacob, Mark G Jones, Bibek Gooptu, Rachel C Chambers, Philip L Molyneaux, Peter M George, Michael A Gibbons, Emma K Denneny, Joanna C Porter, Manuela Platé, Stephen M Bianchi, Chris E Brightling, Richard James Allen, Annemarie Docherty, Jane A Mitchell, Ian P Hall, Jonathan Brooke, Louise V Wain, Malcolm Semple, Raminder Aul, Neil A Hanley, Krisnah Poinasamy, Pilar Rivera-Ortega, DJF Smith, Stefan C Stanel, A A Roger Thompson, Simon LF Walsh, Mark Everard Weeks, Dan G Wootton, Karen Piper Hanley
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/5d520253a7b4481e90cf8d3281a60c82
Autor:
Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183025 (2017)
RationaleNitric oxide synthase (NOS) is a biomarker/target in sepsis. NOS activity is driven by amino acids, which cycle to regulate the substrate L-arginine in parallel with cycles which regulate the endogenous inhibitors ADMA and L-NMMA. The relati
Externí odkaz:
https://doaj.org/article/2e318961191b4024bb0cead40dbb6561
Autor:
Blerina Ahmetaj-Shala, Michael Olanipekun, Abel Tesfai, Niall MacCallum, Nicholas S. Kirkby, Gregory J. Quinlan, Chih-Chin Shih, Ryota Kawai, Sharon Mumby, Mark Paul-Clark, Elizabeth J. Want, Jane A. Mitchell
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Externí odkaz:
https://doaj.org/article/9334704285f14cf0b336bf208608e733
Autor:
Mark Paul-Clark, Wagdi Elsheikh, Nicholas Kirkby, Melissa Chan, Pallavi Devchand, Terence A Agbor, Kyle L Flannigan, Charlotte Cheadle, Maxim Freydin, Angela Ianaro, Jane A Mitchell, John L Wallace
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147289 (2016)
Nonsteroidal anti-inflammatory drugs have been shown to reduce the incidence of gastrointestinal cancers, but the propensity of these drugs to cause ulcers and bleeding limits their use. H2S has been shown to be a powerful cytoprotective and anti-inf
Externí odkaz:
https://doaj.org/article/fd245ce58bce4fb7a72354c9cdeb2d65
Autor:
Nicholas S Kirkby, Martina H Lundberg, William R Wright, Timothy D Warner, Mark J Paul-Clark, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98165 (2014)
Cyxlo-oxygenase (COX)-2 inhibitors, including traditional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with increased cardiovascular side effects, including myocardial infarction. We and others have shown that COX-1 and not COX-2 driv
Externí odkaz:
https://doaj.org/article/496c671654e540fda0ae65c895136f06
Autor:
Daniel M Reed, Gabor Foldes, Timothy Gatheral, Koralia E Paschalaki, Zsuzsanna Lendvai, Zsolt Bagyura, Tamas Nemeth, Judit Skopal, Bela Merkely, Aurica G Telcian, Leila Gogsadze, Michael R Edwards, Peter J Gough, John Bertin, Sebastian L Johnston, Sian E Harding, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e91119 (2014)
Human embryonic stem cell-derived endothelial cells (hESC-EC), as well as other stem cell derived endothelial cells, have a range of applications in cardiovascular research and disease treatment. Endothelial cells sense Gram-negative bacteria via the
Externí odkaz:
https://doaj.org/article/241a3f71d5eb429f83104ac2d430c14d
Autor:
Nicholas S Kirkby, Anne K Zaiss, Paula Urquhart, Jing Jiao, Philip J Austin, Malak Al-Yamani, Martina H Lundberg, Louise S MacKenzie, Timothy D Warner, Anna Nicolaou, Harvey R Herschman, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69524 (2013)
There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found
Externí odkaz:
https://doaj.org/article/18a323ab2fc043b0bc1ea6141626660a
Autor:
William R Wright, Katarzyna Parzych, Damian Crawford, Charles Mein, Jane A Mitchell, Mark J Paul-Clark
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30120 (2012)
BACKGROUND:Cigarette smoking is responsible for 5 million deaths worldwide each year, and is a major risk factor for cardiovascular and lung diseases. Cigarette smoke contains a complex mixture of over 4000 chemicals containing 10(15) free radicals.
Externí odkaz:
https://doaj.org/article/e20de584a3054854855d056f62e1cc99
Autor:
Claire M F Potter, Sophie Schobesberger, Martina H Lundberg, Peter D Weinberg, Jane A Mitchell, Julia Gorelik
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31228 (2012)
To measure the elongation and compliance of endothelial cells subjected to different patterns of shear stress in vitro, and to compare these parameters with the elongation and compliance of endothelial cells from different regions of the intact aorta
Externí odkaz:
https://doaj.org/article/2e413708ca474c9984187484c010c179
A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses.
Autor:
Timothy Gatheral, Daniel M Reed, Laura Moreno, Peter J Gough, Bart J Votta, Clark A Sehon, David J Rickard, John Bertin, Eric Lim, Andrew G Nicholson, Jane A Mitchell
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42386 (2012)
Understanding the mechanisms by which pathogens induce vascular inflammation and dysfunction may reveal novel therapeutic targets in sepsis and related conditions. The intracellular receptor NOD1 recognises peptidoglycan which features in the cell wa
Externí odkaz:
https://doaj.org/article/5d1c7be4724b464285ac6ff607299987