Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jane, Osbourn"'
Autor:
Georgia Bullen, Jacob D. Galson, Gareth Hall, Pedro Villar, Lien Moreels, Line Ledsgaard, Giada Mattiuzzo, Emma M. Bentley, Edward W. Masters, David Tang, Sophie Millett, Danielle Tongue, Richard Brown, Ioannis Diamantopoulos, Kothai Parthiban, Claire Tebbutt, Rachael Leah, Krishna Chaitanya, Sandra Ergueta-Carballo, Deividas Pazeraitis, Sachin B. Surade, Omodele Ashiru, Lucia Crippa, Richard Cowan, Matthew W. Bowler, Jamie I. Campbell, Wing-Yiu Jason Lee, Mark D. Carr, David Matthews, Paul Pfeffer, Simon E. Hufton, Kovilen Sawmynaden, Jane Osbourn, John McCafferty, Aneesh Karatt-Vellatt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Passive immunization using monoclonal antibodies will play a vital role in the fight against COVID-19. The recent emergence of viral variants with reduced sensitivity to some current antibodies and vaccines highlights the importance of broad cross-re
Externí odkaz:
https://doaj.org/article/ecdc7cf013814d728091e23cf673cdda
Autor:
Jacob D. Galson, Sebastian Schaetzle, Rachael J. M. Bashford-Rogers, Matthew I. J. Raybould, Aleksandr Kovaltsuk, Gavin J. Kilpatrick, Ralph Minter, Donna K. Finch, Jorge Dias, Louisa K. James, Gavin Thomas, Wing-Yiu Jason Lee, Jason Betley, Olivia Cavlan, Alex Leech, Charlotte M. Deane, Joan Seoane, Carlos Caldas, Daniel J. Pennington, Paul Pfeffer, Jane Osbourn
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B cell population is also
Externí odkaz:
https://doaj.org/article/77318244b0ea49a7afe210f8b341f044
Autor:
Michael Overstreet, Vanessa Muniz-Medina, Ruoyan Chen, James Kurasawa, Stacy Kentner, Deepali Malhotra, Jane Osbourn, Jill Walker
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/75cbb845e8ff4749aec5d327a3c881a3
Autor:
Junhui Sun, Weidong Hao, Natasha Fillmore, Hanley Ma, Danielle Springer, Zu‐Xi Yu, Agnieszka Sadowska, Andrew Garcia, Ruoyan Chen, Vanessa Muniz‐Medina, Kim Rosenthal, Jia Lin, Denison Kuruvilla, Jane Osbourn, Sotirios K. Karathanasis, Jill Walker, Elizabeth Murphy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 24 (2019)
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin‐2 is a peptide hormone that mediates pleiotropic cardiovascular effects, including antifibrotic, angiog
Externí odkaz:
https://doaj.org/article/c5f74268cf9e4cc6a8104908bee069d8
Autor:
Jill Walker, Jane Osbourn, Arnaud C. Tiberghien, Nazzareno Dimasi, Dipesha P. Shah, Terrence O'Day, Steven Novick, William O. Iverson, Yuling Wu, Bo Zheng, Shannon Breen, Subramanya Karanth, Ryan Fleming, Agnieszka Sadowska, Christopher Ward, Vanessa Muniz-Medina, Suneetha B. Thomas, Elaine M. Hurt, Michael G. Overstreet, Saravanan Rajan, Ruoyan Chen
Multiple myeloma is a hematologic cancer that disrupts normal bone marrow function and has multiple lines of therapeutic options, but is incurable as patients ultimately relapse. We developed a novel antibody–drug conjugate (ADC) targeting CS-1, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063a7b8839eda8429b31260763a0368a
https://doi.org/10.1158/1535-7163.c.6542664
https://doi.org/10.1158/1535-7163.c.6542664
Autor:
Jill Walker, Jane Osbourn, Arnaud C. Tiberghien, Nazzareno Dimasi, Dipesha P. Shah, Terrence O'Day, Steven Novick, William O. Iverson, Yuling Wu, Bo Zheng, Shannon Breen, Subramanya Karanth, Ryan Fleming, Agnieszka Sadowska, Christopher Ward, Vanessa Muniz-Medina, Suneetha B. Thomas, Elaine M. Hurt, Michael G. Overstreet, Saravanan Rajan, Ruoyan Chen
Supplementary Materials and Methods, Supplementary Table S1. Sources of cell lines and cell growth media; Supplemental Table S2. Sources of antibodies for flow cytometry; Supplementary Table S3. CS-1 ADC Characteristics, Supplemental Table S4. Pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62318dd34971780d373a1e55ed154426
https://doi.org/10.1158/1535-7163.22520520.v1
https://doi.org/10.1158/1535-7163.22520520.v1
Autor:
Matthew Kraman, Carlo Zimarino, Danielle Minns, Jorge Dias, Chelsea Povall, Helen Graves, Bradley Holub, Ralph Minter, Jacob Galson, Jane Osbourn, Donna Finch
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1de7b539733754cb66617c7e6ae5ff42
https://doi.org/10.1136/jitc-2022-sitc2022.1353
https://doi.org/10.1136/jitc-2022-sitc2022.1353
Autor:
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan, Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, Vidyashankara Iyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, Dongmei Zhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, Herren Wu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167935 (2016)
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubilit
Externí odkaz:
https://doaj.org/article/c7112dc536a744a789e3b298aa48181d
Autor:
Elizabeth Murphy, Weidong Hao, Andrew Garcia, Hanley Ma, Vanessa Muniz-Medina, Jia Lin, Jill Walker, Kim Rosenthal, Denison Kuruvilla, Junhui Sun, Zu-Xi Yu, Natasha Fillmore, Ruoyan Chen, Sotirios K. Karathanasis, Agnieszka Sadowska, Jane Osbourn, Danielle A. Springer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Heart failure is one of the leading causes of death in Western countries, and there is a need for new therapeutic approaches. Relaxin‐2 is a peptide hormone that mediates pleiotropic cardiovascular effects, including antifibrotic, angiog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda9b49f336b722ca97ba637c3644367
http://europepmc.org/articles/PMC6951077
http://europepmc.org/articles/PMC6951077
Autor:
Bo Zheng, Dipesha P. Shah, Jill Walker, Subramanya Karanth, William O. Iverson, Vanessa Muniz-Medina, Yuling Wu, Ruoyan Chen, Nazzareno Dimasi, Jane Osbourn, Arnaud C. Tiberghien, Suneetha B. Thomas, Saravanan Rajan, Elaine M. Hurt, Shannon Breen, Ryan Fleming, Agnieszka Sadowska, Michael G. Overstreet, Christopher Ward, Terrence O'Day, Steven Novick
Publikováno v:
Molecular cancer therapeutics. 19(8)
Multiple myeloma is a hematologic cancer that disrupts normal bone marrow function and has multiple lines of therapeutic options, but is incurable as patients ultimately relapse. We developed a novel antibody–drug conjugate (ADC) targeting CS-1, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24820dd9755e2b004133692d71eb38f
https://pubmed.ncbi.nlm.nih.gov/32404408
https://pubmed.ncbi.nlm.nih.gov/32404408