Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Jane, Mellor"'
Autor:
Raian E. Contreras, Tim Gruber, Ismael González-García, Sonja C. Schriever, Meri De Angelis, Noemi Mallet, Miriam Bernecker, Beata Legutko, Dhiraj Kabra, Mathias Schmidt, Matthias H. Tschöp, Ruth Gutierrez-Aguilar, Jane Mellor, Cristina García-Cáceres, Paul T. Pfluger
Publikováno v:
Molecular Metabolism, Vol 90, Iss , Pp 102033- (2024)
With age, metabolic perturbations accumulate to elevate our obesity burden. While age-onset obesity is mostly driven by a sedentary lifestyle and high calorie intake, genetic and epigenetic factors also play a role. Among these, members of the large
Externí odkaz:
https://doaj.org/article/89b3b5348a5c4a20ab8e96a7a643232f
Autor:
Silvia Raineri, Julia A. Sherriff, Kevin S. J. Thompson, Huw Jones, Paul T. Pfluger, Nicholas E. Ilott, Jane Mellor
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-21 (2022)
Abstract Background Obesity, metabolic disease and some psychiatric conditions are associated with changes to relative abundance of bacterial species and specific genes in the faecal microbiome. Little is known about the impact of pharmacologically i
Externí odkaz:
https://doaj.org/article/cbbfacdeffaf4e49921e504aedbbeeb6
Autor:
Abigail R. R. Guillermo, Karolina Chocian, Gavriil Gavriilidis, Julien Vandamme, Anna Elisabetta Salcini, Jane Mellor, Alison Woollard
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Evidence of global heterochromatin decay and aberrant gene expression in models of physiological and premature ageing have long supported the “heterochromatin loss theory of ageing”, which proposes that ageing is aetiologicall
Externí odkaz:
https://doaj.org/article/194508ad184f48f08a8ab0577b076117
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109755- (2021)
Summary: Spt4 is a transcription elongation factor with homologs in organisms with nucleosomes. Structural and in vitro studies implicate Spt4 in transcription through nucleosomes, and yet the in vivo function of Spt4 is unclear. Here, we assess the
Externí odkaz:
https://doaj.org/article/18b757a9577544e0bb3ae74bc4ecd5ba
Autor:
Thomas Brown, Françoise S Howe, Struan C Murray, Meredith Wouters, Philipp Lorenz, Emily Seward, Scott Rata, Andrew Angel, Jane Mellor
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 2, Pp 1-21 (2018)
Abstract Antisense transcription is widespread in genomes. Despite large differences in gene size and architecture, we find that yeast and human genes share a unique, antisense transcription‐associated chromatin signature. We asked whether this sig
Externí odkaz:
https://doaj.org/article/c408574a75694f5da6f293c21d61ecc0
Autor:
Víctor Sánchez-Gaya, Salvador Casaní-Galdón, Manuel Ugidos, Zheng Kuang, Jane Mellor, Ana Conesa, Sonia Tarazona
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The Yeast Metabolic Cycle (YMC) is a model system in which levels of around 60% of the yeast transcripts cycle over time. The spatial and temporal resolution provided by the YMC has revealed that changes in the yeast metabolic landscape and chromatin
Externí odkaz:
https://doaj.org/article/ff3c54c32cbe4203bbd6c622af09b88f
Autor:
Silvia Raineri, Jane Mellor
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Mutations in genes encoding enzymes of the tricarboxylic acid cycle often contribute to cancer development and progression by disrupting cell metabolism and altering the epigenetic landscape. This is exemplified by the isoforms of isocitrate dehydrog
Externí odkaz:
https://doaj.org/article/7fc5ed1192d54cf78a4ed011f01d4ef2
Autor:
Françoise S Howe, Andrew Russell, Anna R Lamstaes, Afaf El-Sagheer, Anitha Nair, Tom Brown, Jane Mellor
Publikováno v:
eLife, Vol 6 (2017)
CRISPRi, an adapted CRISPR-Cas9 system, is proposed to act as a strand-specific roadblock to repress transcription in eukaryotic cells using guide RNAs (sgRNAs) to target catalytically inactive Cas9 (dCas9) and offers an alternative to genetic interv
Externí odkaz:
https://doaj.org/article/ed121737be8b4012bce760dad1ea298a
Autor:
David Mant, Alastair Gray, Siân Pugh, Helen Campbell, Stephen George, Alice Fuller, Bethany Shinkins, Andrea Corkhill, Jane Mellor, Elizabeth Dixon, Louisa Little, Rafael Perera-Salazar, John Primrose
Publikováno v:
Health Technology Assessment, Vol 21, Iss 32 (2017)
Background: Intensive follow-up after surgery for colorectal cancer is common practice but lacks a firm evidence base. Objective: To assess whether or not augmenting symptomatic follow-up in primary care with two intensive methods of follow-up [monit
Externí odkaz:
https://doaj.org/article/bc71d44fd7b94ff2ab02a62dceab74cb
Autor:
Steve Thomas Pannakal, Sibylle Jäger, Albert Duranton, Amit Tewari, Subarna Saha, Aneesha Radhakrishnan, Nita Roy, Jean François Kuntz, Soraya Fermas, Darryl James, Jane Mellor, Namita Misra, Lionel Breton
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179813 (2017)
The traditional Indian medicine, Ayurveda, provides insights and practical solutions towards a healthy life style. Rasayana is a branch of Ayurveda known for preserving and promoting health, enhancing the quality of life and delaying the aging proces
Externí odkaz:
https://doaj.org/article/df6e3869af7a42b5bf2ea6da8203b367