Výsledky vyhledávání - "Jane, Escott"

Akademický článek

Zibotentan in systemic sclerosis-associated chronic kidney disease: a phase II randomised placebo-controlled trial

Autor: Edward P. Stern, Lauren V. Host, Ivy Wanjiku, K. Jane Escott, Peter S. Gilmour, Rachel Ochiel, Robert Unwin, Aine Burns, Voon H. Ong, Helen Cadiou, Aidan G. O’Keeffe, Christopher P. Denton

Publikováno v: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)

Abstract Background We report results from a phase II randomised placebo-controlled trial assessing zibotentan, a highly selective endothelin receptor antagonist (ERA), in chronic kidney disease (CKD) secondary to systemic sclerosis (SSc). Methods Th

Externí odkaz: https://doaj.org/article/e076d30c8d2b4636b01f9033cf571d46

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Akademický článek

A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough

Autor: Huda Badri, Carmen Gibbard, Dimitra Denton, Imran Satia, Bashar Al-Sheklly, Rachel J. Dockry, Kimberley Holt, Kevin McGuiness, Sam Treadway, Peter Whorwell, Lesley Houghton, Augustine Lee, K. Jane Escott, Theresa Lee, Greame Wilkinson, Alison Holt, Brendan J. Canning, Jacky A. Smith

Publikováno v: ERJ Open Research, Vol 8, Iss 1 (2022)

Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABAB) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use. Lesogaberan is a novel

Externí odkaz: https://doaj.org/article/cf3a12b94f2440f4b3583988978dc4f8

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Akademický článek

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Effect of centrally and peripherally acting GABA

Autor: Huda, Badri, Carmen, LGibbard, Dimitra, Denton, Imran, Satia, Rachel J, Dockry, Kimberley, Holt, Jane, Escott, Greame, Wilkinson, Alison, Holt, Brendan J, Canning, Jacky A, Smith

Publikováno v: Pulmonary pharmacologytherapeutics. 71

Currently there are no effective licensed anti-tussive therapies. Understanding how the neuronal mechanisms mediating the cough reflex in animal models translate to humans is important for the development of effective therapies. Pre-clinical studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::38e4457a444167f153b09cc1a92911c6
https://pubmed.ncbi.nlm.nih.gov/34571095

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Effect of centrally and peripherally acting GABAB agonism on the healthy human cough reflex

Autor: Brendan J. Canning, Jacky Smith, Huda Badri, Rachel Dockry, Alison Holt, Dimitra Denton, Carmen LGibbard, Kimberley Holt, Jane Escott, Imran Satia, Greame Wilkinson

Publikováno v: Badri, H, Lgibbard, C, Denton, D, Satia, I, Dockry, R J, Holt, K, Escott, J, Wilkinson, G, Holt, A, Canning, B J & Smith, J A 2021, ' Effect of centrally and peripherally acting GABAB agonism on the healthy human cough reflex ', Pulmonary pharmacology & therapeutics, vol. 71, 102079 . https://doi.org/10.1016/j.pupt.2021.102079

BackgroundCurrently there are no effective licensed anti-tussive therapies. Understanding how the neuronal mechanisms mediating the cough reflex in animal models translate to humans is important for the development of effective therapies. Pre-clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edaee3758a32557443417156d5a398f
https://doi.org/10.1016/j.pupt.2021.102079

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Drug repurposing: progress, challenges and recommendations

Autor: Munir Pirmohamed, David Cavalla, Andrew D. Wells, Andrew J. Doig, Philippe Sanseau, Tim Guilliams, Francesco Iorio, Christine J. McNamee, Sudeep Pushpakom, K. Jane Escott, Joanna Latimer, Shirley Hopper, Patrick A. Eyers, Alan Norris

Publikováno v: NATURE REVIEWS DRUG DISCOVERY

Given the high attrition rates, substantial costs and slow pace of new drug discovery and development, repurposing of 'old' drugs to treat both common and rare diseases is increasingly becoming an attractive proposition because it involves the use of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821d3e357a2d91fb1cfb7090bc94e339
https://pubmed.ncbi.nlm.nih.gov/30310233

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GSK-3 beta inhibition suppresses instability-induced osteolysis by a dual action on osteoblast and osteoclast differentiation

Autor: Rune Vinther Madsen, Mathias P.G. Bostrom, Mehdi Amirhosseini, F. Patrick Ross, K. Jane Escott, Anna Fahlgren

Currently, there are no medications available to treat aseptic loosening of orthopedic implants. Using osteoprotegerin fusion protein (OPG-Fc), we previously blocked instability-induced osteoclast differentiation and peri-prosthetic osteolysis. Wnt/b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea294777fd24d7db40b9980581fcbd7
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148660

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Pioneering government-sponsored drug repositioning collaborations: progress and learning

Autor: K. Jane Escott, Craig Wegner, Menelas N. Pangalos, Alison Holt, Chris Watkins, Donald E. Frail, Madeleine Brady, Hitesh J. Sanganee

Publikováno v: Nature Reviews Drug Discovery. 14:833-841

A new model for translational research and drug repositioning has recently been established based on three-way partnerships between public funders, the pharmaceutical industry and academic investigators. Through two pioneering initiatives - one invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa63b7fc4aa2f31824412c65486f5e83
https://doi.org/10.1038/nrd4707

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