The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers

Autor: Janas, C., Mast, M.P., Kirsamer, L., Angioni, C., Gao, F., Mäntele, W., Dressman, J., Wacker, M.G.

The dispersion releaser (DR) is a dialysis-based setup for the analysis of the drug release from nanosized drug carriers. It is mounted into dissolution apparatus 2 of the United States Pharmacopoeia. The present study evaluated the DR technique inve

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https://publica.fraunhofer.de/handle/publica/251732

A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes.

Autor: Wallenwein CM; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt (Main), Germany; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt (Main), Germany., Nova MV; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt (Main), Germany; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt (Main), Germany., Janas C; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt (Main), Germany., Jablonka L; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt (Main), Germany; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt (Main), Germany., Gao GF; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt (Main), Germany., Thurn M; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt (Main), Germany; Institute of Pharmaceutical Technology, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt (Main), Germany., Albrecht V; Biolitec Research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany., Wiehe A; Biolitec Research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany., Wacker MG; National University of Singapore, Department of Pharmacy, 6 Science Drive 2, Singapore 117546, Singapore. Electronic address: phamgw@edu.nus.sg.

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2019 Oct; Vol. 143, pp. 44-50. Date of Electronic Publication: 2019 Aug 14.

The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers.

Autor: Janas C; Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany., Mast MP; Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany., Kirsamer L; Goethe University, Institute for Biophysics, D-60438 Frankfurt, Germany., Angioni C; Goethe University, Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, D-60590 Frankfurt, Germany., Gao F; Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany., Mäntele W; Goethe University, Institute for Biophysics, D-60438 Frankfurt, Germany., Dressman J; Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany., Wacker MG; Goethe University, Institute of Pharmaceutical Technology, D-60438 Frankfurt, Germany; Fraunhofer-Institute for Molecular Biology and Applied Ecology, Department of Pharmaceutical Technology and Nanosciences, D-60438 Frankfurt, Germany. Electronic address: matthias.wacker@ime.fraunhofer.de.

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2017 Jun; Vol. 115, pp. 73-83. Date of Electronic Publication: 2017 Feb 16.

Nanocarriers for photodynamic therapy-rational formulation design and medium-scale manufacture.

Autor: Villa Nova M; Laboratory of R&D of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, Brazil., Janas C; Institute of Pharmaceutical Technology, Goethe University, 60438 Frankfurt (Main), Germany., Schmidt M; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany., Ulshoefer T; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany., Gräfe S; biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany., Schiffmann S; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany., de Bruin N; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany., Wiehe A; biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany., Albrecht V; biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany., Parnham MJ; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany., Luciano Bruschi M; Laboratory of R&D of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringá, Av. Colombo, 5790, Maringá, Paraná, Brazil., Wacker MG; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Project group for Translational Medicine & Pharmacology (TMP), 60596 Frankfurt/ Main, Germany. Electronic address: matthias.wacker@ime.fraunhofer.de.

Publikováno v: International journal of pharmaceutics [Int J Pharm] 2015 Aug 01; Vol. 491 (1-2), pp. 250-60. Date of Electronic Publication: 2015 Jun 26.

Miniaturized screening of polymers for amorphous drug stabilization (SPADS): rapid assessment of solid dispersion systems.

Autor: Wyttenbach N; pRED, Small Molecule Research, Formulation Research, F. Hoffmann-La Roche AG, Basel, Switzerland. nicole.wyttenbach@roche.com, Janas C, Siam M, Lauer ME, Jacob L, Scheubel E, Page S

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2013 Aug; Vol. 84 (3), pp. 583-98. Date of Electronic Publication: 2013 Feb 08.