Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Janani Iyer"'
Autor:
Marissa Burke, Kelly Wong, Yuli Talyansky, Siddhita D. Mhatre, Carol Mitchell, Cassandra M. Juran, Makaila Olson, Janani Iyer, Stephanie Puukila, Candice G. T. Tahimic, Lane K. Christenson, Moniece Lowe, Linda Rubinstein, Yasaman Shirazi-Fard, Marianne B. Sowa, Joshua S. Alwood, April E. Ronca, Amber M. Paul
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Exposure to cosmic ionizing radiation is an innate risk of the spaceflight environment that can cause DNA damage and altered cellular function. In astronauts, longitudinal monitoring of physiological systems and interactions between these sy
Externí odkaz:
https://doaj.org/article/a49ceff1b5d94721b1f2bc6e8f711071
Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids
Autor:
Jennifer Chou, Johnny R. Ramroop, Amanda M. Saravia-Butler, Brian Wey, Matthew P. Lera, Medaya L. Torres, Mary Ellen Heavner, Janani Iyer, Siddhita D. Mhatre, Sharmila Bhattacharya, Shubha Govind
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108759- (2024)
Summary: While fruit flies (Drosophila melanogaster) and humans exhibit immune system dysfunction in space, studies examining their immune systems’ interactions with natural parasites in space are lacking. Drosophila parasitoid wasps modify blood c
Externí odkaz:
https://doaj.org/article/a629fa82de41491d937df4a70a74b200
Autor:
Joshua S. Alwood, Ajitkumar P. Mulavara, Janani Iyer, Siddhita D. Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W. Jones, Xiao Wen Mao, Rajeev I. Desai, Alexandra M. Whitmire, Thomas J. Williams
Publikováno v:
Life, Vol 13, Iss 9, p 1852 (2023)
Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain region
Externí odkaz:
https://doaj.org/article/fae5ebc0ec5a4b04b825de8bc8b7ab7e
Autor:
Stephanie Puukila, Olivia Siu, Linda Rubinstein, Candice G. T. Tahimic, Moniece Lowe, Steffy Tabares Ruiz, Ivan Korostenskij, Maya Semel, Janani Iyer, Siddhita D. Mhatre, Yasaman Shirazi-Fard, Joshua S. Alwood, Amber M. Paul, April E. Ronca
Publikováno v:
Life, Vol 13, Iss 5, p 1214 (2023)
Exposure to space galactic cosmic radiation is a principal consideration for deep space missions. While the effects of space irradiation on the nervous system are not fully known, studies in animal models have shown that exposure to ionizing radiatio
Externí odkaz:
https://doaj.org/article/783b8f85f80648558e9d9925d3da7f2f
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 16, Iss 4, Pp ZR01-ZR04 (2022)
Present case series describes the three different types of attachments use for tooth supported overdenture for prosthetic rehabilitation. Loss of teeth causes continuous resorption of the bone leading to a compromised treatment. Retaining two or more
Externí odkaz:
https://doaj.org/article/782031c5ff0e41cdb1b8b43381daecac
Autor:
Lucilla Pizzo, Micaela Lasser, Tanzeen Yusuff, Matthew Jensen, Phoebe Ingraham, Emily Huber, Mayanglambam Dhruba Singh, Connor Monahan, Janani Iyer, Inshya Desai, Siddharth Karthikeyan, Dagny J Gould, Sneha Yennawar, Alexis T Weiner, Vijay Kumar Pounraja, Arjun Krishnan, Melissa M Rolls, Laura Anne Lowery, Santhosh Girirajan
Publikováno v:
PLoS Genetics, Vol 17, Iss 4, p e1009112 (2021)
We previously identified a deletion on chromosome 16p12.1 that is mostly inherited and associated with multiple neurodevelopmental outcomes, where severely affected probands carried an excess of rare pathogenic variants compared to mildly affected ca
Externí odkaz:
https://doaj.org/article/ea88765e5dca40999d37fc1d27f96ec3
Autor:
Tanzeen Yusuff, Matthew Jensen, Sneha Yennawar, Lucilla Pizzo, Siddharth Karthikeyan, Dagny J Gould, Avik Sarker, Erika Gedvilaite, Yurika Matsui, Janani Iyer, Zhi-Chun Lai, Santhosh Girirajan
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008792 (2020)
While rare pathogenic copy-number variants (CNVs) are associated with both neuronal and non-neuronal phenotypes, functional studies evaluating these regions have focused on the molecular basis of neuronal defects. We report a systematic functional an
Externí odkaz:
https://doaj.org/article/5f99cb0ded5442ca8e008ae6d0d92172
Autor:
Mayanglambam Dhruba Singh, Matthew Jensen, Micaela Lasser, Emily Huber, Tanzeen Yusuff, Lucilla Pizzo, Brian Lifschutz, Inshya Desai, Alexis Kubina, Sneha Yennawar, Sydney Kim, Janani Iyer, Diego E Rincon-Limas, Laura Anne Lowery, Santhosh Girirajan
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008590 (2020)
The 1.6 Mbp deletion on chromosome 3q29 is associated with a range of neurodevelopmental disorders, including schizophrenia, autism, microcephaly, and intellectual disability. Despite its importance towards neurodevelopment, the role of individual ge
Externí odkaz:
https://doaj.org/article/70c2a6475aa74212a798ae4353e5a86f
Autor:
Janani Iyer, Mayanglambam Dhruba Singh, Matthew Jensen, Payal Patel, Lucilla Pizzo, Emily Huber, Haley Koerselman, Alexis T. Weiner, Paola Lepanto, Komal Vadodaria, Alexis Kubina, Qingyu Wang, Abigail Talbert, Sneha Yennawar, Jose Badano, J. Robert Manak, Melissa M. Rolls, Arjun Krishnan, Santhosh Girirajan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 gen
Externí odkaz:
https://doaj.org/article/d7ac17fe1f8f4fac96fe435cdcaaa18c
Autor:
Janani Iyer, Qingyu Wang, Thanh Le, Lucilla Pizzo, Sebastian Grönke, Surendra S. Ambegaokar, Yuzuru Imai, Ashutosh Srivastava, Beatriz Llamusí Troisí, Graeme Mardon, Ruben Artero, George R. Jackson, Adrian M. Isaacs, Linda Partridge, Bingwei Lu, Justin P. Kumar, Santhosh Girirajan
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 5, Pp 1427-1437 (2016)
About two-thirds of the vital genes in the Drosophila genome are involved in eye development, making the fly eye an excellent genetic system to study cellular function and development, neurodevelopment/degeneration, and complex diseases such as cance
Externí odkaz:
https://doaj.org/article/72d18acb1b274b0f8846de16bf2ebfcc