Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Autor: Cho Yeow Koh, Norrapat Shih, Christina Y. C. Yip, Aaron Wei Liang Li, Weiming Chen, Fathiah S. Amran, Esther Jia En Leong, Janaki Krishnamoorthy Iyer, Grace Croft, Muhammad Ibrahim Bin Mazlan, Yen-Lin Chee, Eng-Soo Yap, Dougald M. Monroe, Maureane Hoffman, Richard C. Becker, Dominique P. V. de Kleijn, Vaishali Verma, Amita Gupta, Vijay K. Chaudhary, A. Mark Richards, R. Manjunatha Kini, Mark Y. Chan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used i

Externí odkaz: https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

Autor: Reka A. Otvos, Janaki Krishnamoorthy Iyer, René van Elk, Chris Ulens, Wilfried M. A. Niessen, Govert W. Somsen, R. Manjunatha Kini, August B. Smit, Jeroen Kool

Publikováno v: Toxins, Vol 7, Iss 7, Pp 2336-2353 (2015)

The 5-HT3 receptor is a ligand-gated ion channel, which is expressed in the nervous system. Its antagonists are used clinically for treatment of postoperative- and radiotherapy-induced emesis and irritable bowel syndrome. In order to better understan

Externí odkaz: https://doaj.org/article/0bcd8222bddc492cb2f1aad3e6d57a63

Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency

Autor: Catherine P.M. Hayward, Karen A. Moffat, M. S. Badin, Justin Brunet, Marnie Timleck, E. Spitzer, L. Graf, Janaki Krishnamoorthy Iyer

Publikováno v: International Journal of Laboratory Hematology. 40:400-407

INTRODUCTION Dense granule (DG) deficiency (DGD) is a feature of some platelet function disorders (PFD) with a prevalence similar to von Willebrand disease. Most laboratories assess for DGD using whole mount platelet preparations and electron microsc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a795de40160f05c3f5dce6e63611978
https://doi.org/10.1111/ijlh.12801

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Autor: Nicholas R. Casewell, Julien Slagboom, Jeroen C. Visser, Ryan J. R. McCleary, Fernanda C. Cardoso, Jeroen Kool, August B. Smit, Bjorn R. van Doodewaerd, Janaki Krishnamoorthy Iyer, Govert W. Somsen, Reka A. Otvos, Richard J. Lewis, Wilfried M. A. Niessen, R. Manjunatha Kini

Publikováno v: Slagboom, J, Otvos, R A, Cardoso, F C, Iyer, J, Visser, J C, van Doodewaerd, B R, McCleary, R J R, Niessen, W M A, Somsen, G W, Lewis, R J, Kini, R M, Smit, A B, Casewell, N R & Kool, J 2018, ' Neurotoxicity fingerprinting of venoms using
microfluidic AChBP profiling ', Toxicon, vol. 148, pp. 213-222 . https://doi.org/10.1016/j.toxicon.2018.04.022
Toxicon, 148, 213-222. Elsevier Limited

Venoms from snakes are rich sources of highly active proteins with potent affinity towards a variety of enzymes and receptors. Of the many distinct toxicities caused by envenomation, neurotoxicity plays an important role in the paralysis of prey by s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00bd1665bed78a0a36926162e7070e2
https://research.vu.nl/en/publications/d097d741-7419-4931-af63-fbdd15de032b

Avathrin: a novel thrombin inhibitor derived from a multi-copy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum

Autor: Kunchithapadam Swaminathan, Sadaaki Iwanaga, Patricia A. Nuttall, Cho Yeow Koh, R. Manjunatha Kini, Janaki Krishnamoorthy Iyer, Jun Mizuguchi, Mark Y. Chan, Ladislav Roller, Chacko Jobichen, Mária Kazimírová

Publikováno v: FASEB Journal. 31(7)

Tick saliva is a rich source of antihemostatic compounds. We amplified a cDNA from the salivary glands of the tropical bont tick (Amblyomma variegatum) using primers based on the variegin sequence, which we previously identified as a novel thrombin i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d14305034f635ba65f286ff74db8820
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