Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Janak Khimchand Padia"'
Autor:
Marek W. Cholody, Kapil N. Bhalla, Anupam Verma, Glynn Weldon Gilcrease, Jared Bearss, Sunil Sharma, Janak Khimchand Padia, Stephen Horrigan, Hariprasad Vankayalapati, Raffaella Soldi, Venkataswamy Sorna
Publikováno v:
Journal of medicinal chemistry. 58(15)
The Wnt/β-catenin signaling pathway plays a vital role in cell growth, the regulation, cell development, and the differentiation of normal stem cells. Constitutive activation of the Wnt/β-catenin signaling pathway is found in many human cancers, an
Autor:
Randy Ramharack, Peggy Liao, Janak Khimchand Padia, Bruce D. Roth, Patt William Chester, Helen Tsenwhei Lee, Mark A Spahr, Jason K. Pontrello, Karen Elaine Sexton, Mark A. Massa
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4827-4845
Compounds of the general structure A and B were investigated for their activity as lipoprotein(a), [Lp(a)], assembly (coupling) inhibitors. SAR around the amino acid derivatives (structure A) gave compound 14-6 as a potent coupling inhibitor. Oral do
Autor:
Janak Khimchand Padia, Bruce David Roth, N. Suman-Chauhan, Julius Pablo, Bharat Kalidas Trivedi, Lakhbir Singh, Mark J. Field, Ken Meecham, Louise Webdale, Rob D. Pinnock, Joanna Hinton
Publikováno v:
Journal of medicinal chemistry. 41(7)
We have designed a novel series of CCK-B receptor antagonists by combining key pharmacophores, an arylurea moiety of 1 and a quinazolinone ring of 3, from two known series. Our earlier studies showed that compounds with methylene linkers in our "targ
Autor:
C.O. Kneen, Janak Khimchand Padia, N. Suman-Chauhan, Louise Webdale, Lakhbir Singh, D S Wright, D.R. Hill, J P Hinton, Mark J. Field, M.C. Pritchard, A Holmes, S Rose, Philip Boden, J. M. Eden, Bharat K. Trivedi
Publikováno v:
Journal of medicinal chemistry. 41(1)
We have previously described the design and development of CI-988, a peptoid analogue of CCK-4 with excellent binding affinity and selectivity for the CCK-B receptor. Due to its anxiolytic profile in animal models of anxiety, this compound was develo