Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies

Autor: Fátima Duarte Freire, Túlio Flávio Accioly de Lima e Moura, Fernanda Nervo Raffin, Cícero Flávio Soares Aragão, Janaina da Silva Goes

Publikováno v: Brazilian Journal of Pharmaceutical Sciences, Vol 55 (2019)
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18015
Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18015
Brazilian Journal of Pharmaceutical Sciences
Universidade de São Paulo (USP)
instacron:USP

Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it unde

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