Výsledky vyhledávání - "Janaiah Kota"

Akademický článek

Global targetome analysis reveals critical role of miR-29a in pancreatic stellate cell mediated regulation of PDAC tumor microenvironment

Autor: Shatovisha Dey, Sheng Liu, Tricia D. Factora, Solaema Taleb, Primavera Riverahernandez, Lata Udari, Xiaoling Zhong, Jun Wan, Janaiah Kota

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of malignancies with a nearly equal incidence and mortality rates in patients. Pancreatic stellate cells (PSCs) are critical players in PDAC microenvironm

Externí odkaz: https://doaj.org/article/8260258835e8483c96a6471f06f99b2b

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Akademický článek

Loss of miR-29a/b1 promotes inflammation and fibrosis in acute pancreatitis

Autor: Shatovisha Dey, Lata M. Udari, Primavera RiveraHernandez, Jason J. Kwon, Brandon Willis, Jeffrey J. Easler, Evan L. Fogel, Stephen Pandol, Janaiah Kota

Publikováno v: JCI Insight, Vol 6, Iss 19 (2021)

MicroRNA-29 (miR-29) is a critical regulator of fibroinflammatory processes in human diseases. In this study, we found a decrease in miR-29a in experimental and human chronic pancreatitis, leading us to investigate the regulatory role of the miR-29a/

Externí odkaz: https://doaj.org/article/ccd29945ae6d4cd399638e7be17fca29

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Akademický článek

A Systematic Review of miR-29 in Cancer

Autor: Jason J. Kwon, Tricia D. Factora, Shatovisha Dey, Janaiah Kota

Publikováno v: Molecular Therapy: Oncolytics, Vol 12, Iss , Pp 173-194 (2019)

MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a wel

Externí odkaz: https://doaj.org/article/dcbfb29077f94378b37e8433aa22d988

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Akademický článek

Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice

Autor: Kayla A. Quirin, Jason J. Kwon, Arafat Alioufi, Tricia Factora, Constance J. Temm, Max Jacobsen, George E. Sandusky, Kim Shontz, Louis G. Chicoine, K. Reed Clark, Joshua T. Mendell, Murray Korc, Janaiah Kota

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 8-20 (2018)

Recombinant adeno-associated virus (rAAV)-mediated gene delivery shows promise to transduce the pancreas, but safety/efficacy in a neoplastic context is not well established. To identify an ideal AAV serotype, route, and vector dose and assess safety

Externí odkaz: https://doaj.org/article/cf264a0361034b6aa1a667a262402c19

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