In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)

Autor: Thomas Kurz, Finn K. Hansen, Matthias U. Kassack, Lena Schumacher, Gerhard Fritz, Annabelle Friedrich, Marc Pflieger, Wynand P. Roos, Jana van Stuijvenberg, Ann-Sophie Assmann, Wolfgang A. Schulz

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 13
International Journal of Molecular Sciences, Vol 21, Iss 4747, p 4747 (2020)

Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of non-malignant diseases, HDACi with a wide therapeutic window and low hazard potential are

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