1540 Age-associated NAD decline impairs mitochondrial fitness and function of CAR-T cells

Autor: George Coukos, Denis Migliorini, Helen Carrasco Hope, Jana de Sostoa, Pierpaolo Ginefra, Yi-Hsuan Chiang, Cristina Jimenez Luna, Jesús Corria Osorio, Nicola Vannini

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/d29c7a86c27646b684926a5246e95264

Evidence of Anti-tumoral Efficacy in an Immune Competent Setting with an iRGD-Modified Hyaluronidase-Armed Oncolytic Adenovirus

Autor: Ahmed Abdullah Al-Zaher, Rafael Moreno, Carlos Alberto Fajardo, Marcel Arias-Badia, Martí Farrera, Jana de Sostoa, Luis Alfonso Rojas, Ramon Alemany

Publikováno v: Molecular Therapy: Oncolytics, Vol 8, Iss , Pp 62-70 (2018)

To enhance adenovirus-mediated oncolysis, different approaches that tackle the selectivity, tumor penetration, and spreading potential of oncolytic adenoviruses have been reported. We have previously demonstrated that insertion of the internalizing A

Externí odkaz: https://doaj.org/article/0a2e8c7b9ae940cbaf08ac217ac2324d

Data from Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy

Autor: Ramon Alemany, Carl H. June, Jana de Sostoa, Marcel Arias-Badia, Rafael Moreno, Luis Alfonso Rojas, Sonia Guedan, Carlos Alberto Fajardo

Antiviral immune responses present a major hurdle to the efficacious use of oncolytic adenoviruses as cancer treatments. Despite the existence of a highly immunosuppressive tumor environment, adenovirus-infected cells can nonetheless be efficiently c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c46b4182d57e3acbc6928d98fc9fb4a
https://doi.org/10.1158/0008-5472.c.6509795

Supplementary Figures 1 through 7, Supplementary Tables 1 and 3, and Supplementary Materials and Methods from Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression

Autor: Purificación Muñoz, Francesc Viñals, Alberto Villanueva, Manel Esteller, Miguel Ángel Pujana, Antonio Gómez Moruno, Eva González-Suárez, Annie Rodolosse, Joan Maria Viñals, Oriol Bermejo, Diana Pérez Sidelnikova, Rosa M. Penín, Maria Urpí, Jana de Sostoa, Adrià Bernat-Peguera, Pilar Simón-Extremera, Victoria da Silva-Diz

Figure S1. Generation and characterization of orthotopic SCC lineages. Figure S2. Analysis of CSC frequency and EMT induction during SCC progression. Figure S3. Characterization of primary culture cells derived of WD-SCCs and PD/S-SCCs. Figure S4. Ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e9ee1b6e9257073379ebbb403299ec
https://doi.org/10.1158/0008-5472.22409586.v1

Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness

Autor: Rafael Moreno, Ramon Alemany, Estela Núñez-Manchón, Jana de Sostoa, Cristina Fillat, Martí Farrera-Sal, Miriam Bazan-Peregrino

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 14
Dipòsit Digital de la UB
Universidad de Barcelona
International Journal of Molecular Sciences, Vol 21, Iss 5158, p 5158 (2020)

Oncolytic adenoviruses (OAds) present limited efficacy in clinics. The insertion of therapeutic transgenes into OAds genomes, known as &ldquo
arming OAds&rdquo
has been the main strategy to improve their therapeutic potential. Different app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5193d2f818cb4e6f626c6a5e81350f16