Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Jana Zdarova-Karasova"'
Autor:
Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho
Publikováno v:
BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes. Methods To det
Externí odkaz:
https://doaj.org/article/ba8425cd990247f4bd02fb26adefa794
Autor:
Jana Zdarova-Karasova, Martina Hrabinova, Kamil Kuca, Ladislav Novotný, Jan Misík, Miroslav Pohanka
Publikováno v:
Sensors, Vol 9, Iss 5, Pp 3627-3634 (2009)
Cholinesterase activity in blood of laboratory rats was monitored. Rats were intoxicated with paraoxon at dosis of 0 – 65 – 125 – 170 – 250 – 500 nmol. The 250 nmol dose was found to be the LD50. An electrochemical sensor was found useful t
Externí odkaz:
https://doaj.org/article/9626dc0af5dc46088c4fbd7122af2fb5
Autor:
Martin Valis, Alzbeta Dlabkova, Jakub Hort, Francesco Angelucci, Jaroslav Pejchal, Kamil Kuca, Zbysek Pavelek, Jana Zdarova Karasova, Michal Novotny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115226- (2023)
Externí odkaz:
https://doaj.org/article/e9d9c5fb4f944a3ab5793b47851d58ee
Autor:
Martin Valis, Alzbeta Dlabkova, Jakub Hort, Francesco Angelucci, Jaroslav Pejchal, Kamil Kuca, Zbysek Pavelek, Jana Zdarova Karasova, Michal Novotny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114223- (2023)
Background: The acetylcholinesterase inhibitor donepezil is administered as a treatment for Alzheimer's disease (AD). However, the appropriate donepezil dosage is still a matter of debate. Methods: Forty AD patients receiving 10 mg/day of donepezil w
Externí odkaz:
https://doaj.org/article/9493af4d107e474493dfe188b7444fcc
Autor:
Chrysostomi Christina Tsianou, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Stanislav Rejchrt, Martin Valis, Jana Zdarova Karasova, Ilja Tacheci, Veronika Knoblochova, Ondrej Soukup, Jan Bures
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286386 (2023)
BackgroundRivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clin
Externí odkaz:
https://doaj.org/article/18153c20d6b24bac911c694b74ac254a
Autor:
Jiri Kassa, Jana Zdarova Karasova
Publikováno v:
Toxicology Mechanisms and Methods. :1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1bd0b39c76c9ba89bcb9f6c7f1b79d
https://doi.org/10.1080/15376516.2023.2202730
https://doi.org/10.1080/15376516.2023.2202730
Autor:
Jan Bures, Jaroslav Kvetina, Vera Radochova, Ilja Tacheci, Eva Peterova, David Herman, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Tomas Douda, Vit Sestak, Ladislav Douda, Jana Zdarova Karasova
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227781 (2020)
BACKGROUND:Memantine, currently available for the treatment of Alzheimer's disease, is an uncompetitive antagonist of the N-methyl-D-aspartate type of glutamate receptors. Under normal physiologic conditions, these unstimulated receptor ion channels
Externí odkaz:
https://doaj.org/article/29c4d9cce488436da5450f497c763729
Autor:
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Martin Valis, Stanislav Rejchrt, Veronika Knoblochova, Jana Zdarova Karasova
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 590 (2021)
Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoe
Externí odkaz:
https://doaj.org/article/18dd72615a184ffbb613d098ea3a205c
Autor:
Martin Valis, David Herman, Nela Vanova, Jiri Masopust, Oldrich Vysata, Jakub Hort, Zbysek Pavelek, Blanka Klimova, Kamil Kuca, Jan Misik, Jana Zdarova Karasova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Memantine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist utilized as a palliative cure for Alzheimer’s disease. This is the second study examining the memantine concentrations in cerebrospinal fluid. The previously published st
Externí odkaz:
https://doaj.org/article/eadf77827c654fb3b821b45dd8aee3ef
Autor:
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova
Publikováno v:
Molecules, Vol 26, Iss 8, p 2160 (2021)
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet. Pharmacokinetic parameters of d
Externí odkaz:
https://doaj.org/article/42d2564ea2aa4166bfcad13a00e081d3