Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Jana Zdarova Karasova"'
Autor:
Martin Valis, Alzbeta Dlabkova, Jakub Hort, Francesco Angelucci, Jaroslav Pejchal, Kamil Kuca, Zbysek Pavelek, Jana Zdarova Karasova, Michal Novotny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115226- (2023)
Externí odkaz:
https://doaj.org/article/e9d9c5fb4f944a3ab5793b47851d58ee
Autor:
Martin Valis, Alzbeta Dlabkova, Jakub Hort, Francesco Angelucci, Jaroslav Pejchal, Kamil Kuca, Zbysek Pavelek, Jana Zdarova Karasova, Michal Novotny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114223- (2023)
Background: The acetylcholinesterase inhibitor donepezil is administered as a treatment for Alzheimer's disease (AD). However, the appropriate donepezil dosage is still a matter of debate. Methods: Forty AD patients receiving 10 mg/day of donepezil w
Externí odkaz:
https://doaj.org/article/9493af4d107e474493dfe188b7444fcc
Autor:
Chrysostomi Christina Tsianou, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Stanislav Rejchrt, Martin Valis, Jana Zdarova Karasova, Ilja Tacheci, Veronika Knoblochova, Ondrej Soukup, Jan Bures
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0286386 (2023)
BackgroundRivastigmine is a pseudo-irreversible cholinesterase inhibitor used for therapy of Alzheimer's disease and non-Alzheimer dementia syndromes. In humans, rivastigmine can cause significant gastrointestinal side effects that can limit its clin
Externí odkaz:
https://doaj.org/article/18153c20d6b24bac911c694b74ac254a
Autor:
Jan Bures, Jaroslav Kvetina, Vera Radochova, Ilja Tacheci, Eva Peterova, David Herman, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Tomas Douda, Vit Sestak, Ladislav Douda, Jana Zdarova Karasova
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227781 (2020)
BACKGROUND:Memantine, currently available for the treatment of Alzheimer's disease, is an uncompetitive antagonist of the N-methyl-D-aspartate type of glutamate receptors. Under normal physiologic conditions, these unstimulated receptor ion channels
Externí odkaz:
https://doaj.org/article/29c4d9cce488436da5450f497c763729
Autor:
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Martin Valis, Stanislav Rejchrt, Veronika Knoblochova, Jana Zdarova Karasova
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 590 (2021)
Galantamine has been used as a treatment for Alzheimer disease. It has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). Nausea (in about 20%), vomiting (10%) and diarrhoe
Externí odkaz:
https://doaj.org/article/18dd72615a184ffbb613d098ea3a205c
Autor:
Martin Valis, David Herman, Nela Vanova, Jiri Masopust, Oldrich Vysata, Jakub Hort, Zbysek Pavelek, Blanka Klimova, Kamil Kuca, Jan Misik, Jana Zdarova Karasova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Memantine is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist utilized as a palliative cure for Alzheimer’s disease. This is the second study examining the memantine concentrations in cerebrospinal fluid. The previously published st
Externí odkaz:
https://doaj.org/article/eadf77827c654fb3b821b45dd8aee3ef
Autor:
Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Lukas Prchal, Darina Kohoutova, Martin Valis, Martin Novak, Rafael Dolezal, Marcela Kopacova, Stanislav Rejchrt, Vit Sestak, Veronika Knoblochova, Eva Peterova, Jana Zdarova Karasova
Publikováno v:
Molecules, Vol 26, Iss 8, p 2160 (2021)
Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diarrhea, occur in 20–30% of patients. The pathogenesis of these dysmotility associated disorders has not been fully clarified yet. Pharmacokinetic parameters of d
Externí odkaz:
https://doaj.org/article/42d2564ea2aa4166bfcad13a00e081d3
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7883 (2020)
Antidotes against organophosphates often possess physicochemical properties that mitigate their passage across the blood–brain barrier. Cucurbit[7]urils may be successfully used as a drug delivery system for bisquaternary oximes and improve central
Externí odkaz:
https://doaj.org/article/4c838e3f7fb3438484f00fab4adbd382
Autor:
Kamil Kuca, Brian J. Bennion, Rafael Dolezal, Filip Zemek, Vendula Sepsova, Jana Zdarova Karasova, Jan Korabecny
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 16882-16900 (2013)
Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity. H
Externí odkaz:
https://doaj.org/article/e19b4f37d9ec4d0297c7104bfe17610c
Autor:
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova
Publikováno v:
Molecules, Vol 14, Iss 12, Pp 4915-4921 (2009)
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and butyryl
Externí odkaz:
https://doaj.org/article/2f2fa07940354b5097e604981538403b