Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jana Vargova"'
Autor:
Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://doaj.org/article/6487d4fed0064893867020e3dda083eb
Autor:
Viktória Buľková, Jana Vargová, Marián Babinčák, Rastislav Jendželovský, Zbyněk Zdráhal, Pavel Roudnický, Ján Košuth, Peter Fedoročko
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 163, Iss , Pp 114829- (2023)
The presence of key hypoxia regulators, namely, hypoxia-inducible factor (HIF)-1α or HIF-2α, in tumors is associated with poor patient prognosis. Hypoxia massively activates several genes, including the one encoding the BCRP transporter that proffe
Externí odkaz:
https://doaj.org/article/19987f68c8654c6486eade0e3a6e5a2f
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1075 (2022)
It is more than sixty years since the era of modern photodynamic therapy (PDT) for cancer began. Enhanced selectivity for malignant cells with a reduced selectivity for non-malignant cells and good biocompatibility along with the limited occurrence o
Externí odkaz:
https://doaj.org/article/e63aa1a21ecf4a61a249e5e97710d241
Autor:
Marián Babinčák, Rastislav Jendželovský, Ján Košuth, Martin Majerník, Jana Vargová, Kamil Mikulášek, Zbyněk Zdráhal, Peter Fedoročko
Publikováno v:
Cancers, Vol 13, Iss 7, p 1646 (2021)
Skyrin (SKR) is a plant bisanthraquinone secondary metabolite from the Hypericum genus with potential use in anticancer therapy. However, its effect and mechanism of action are still unknown. The negative effect of SKR on HCT 116 and HT-29 cancer cel
Externí odkaz:
https://doaj.org/article/e541d22929c34847b60538d145ae1617
Autor:
Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnatova, Tomáš Kučera, Petr Bzonek, Nikola Novakova, Daniel Jun, Lucie Junova, Jan Korábečný, Kamil Kuča, Mária Kožurková
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3830 (2021)
A series of novel C4-C7-tethered biscoumarin derivatives (12a–e) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin 12d was found to be the most effective inhibitor of both acetyl
Externí odkaz:
https://doaj.org/article/8c388bb7284d4588979e48d7f965924d
Autor:
Eva Konkoľová, Monika Hudáčová, Slávka Hamuľaková, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Mária Kožurková
Publikováno v:
Molecules, Vol 26, Iss 4, p 1133 (2021)
A549 human lung carcinoma cell lines were treated with a series of new drugs with both tacrine and coumarin pharmacophores (derivatives 1a–2c) in order to test the compounds’ ability to inhibit both cancer cell growth and topoisomerase I and II a
Externí odkaz:
https://doaj.org/article/0af2efc10a534d30b4ed3b66d04503a4