Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jana Tchekalarova"'
Autor:
Jana Tchekalarova, Desislava Krushovlieva, Petj Ivanova, Zlatina Nenchovska, Gergana Toteva, Milena Atanasova
Publikováno v:
Behavioral and Brain Functions, Vol 20, Iss 1, Pp 1-14 (2024)
Abstract Background Aging affects anxiety levels in rats while the pineal gland, via its hormone melatonin, could modulate their inherited life “clock.” The present study aimed to explore the impact of plasma melatonin deficiency on anxiety respo
Externí odkaz:
https://doaj.org/article/5c258f268aa24ea5bb42ff74662c68a1
Autor:
Stela Georgieva, Petar Todorov, Jana Tchekalarova, Subaer Subaer, Petia Peneva, Kalin Chakarov, Hartati Hartati, Sitti Faika
Publikováno v:
Pharmaceuticals, Vol 17, Iss 6, p 770 (2024)
The discovery of new peptides and their derivatives is an outcome of ongoing efforts to identify a peptide with significant biological activity for effective usage as a possible therapeutic agent. Spinorphin peptides have been documented to exhibit n
Externí odkaz:
https://doaj.org/article/8d90d9e0658a40ecbbb76eddc5f54ac4
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2912 (2023)
Four 5,5′-diphenylhydantoin Schiff bases possessing different aromatic species (SB1–SB4) were recently synthesized and characterized using spectroscopic and electrochemical tools. The present study aimed to ascertain the anticonvulsant activity o
Externí odkaz:
https://doaj.org/article/7be3df2ff10a438f8a2a8d4f38a64de5
Autor:
Jana Tchekalarova, Natasha Ivanova, Zlatina Nenchovska, Rumiana Tzoneva, Tzveta Stoyanova, Veselina Uzunova, Slavina Surcheva, Alex Tzonev, Violina T. Angelova, Pavlina Andreeva-Gateva
Publikováno v:
Saudi Pharmaceutical Journal, Vol 28, Iss 12, Pp 1566-1579 (2020)
Based on the pharmacophore model of melatonin (MT1) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents. In the present study, the three most potent
Externí odkaz:
https://doaj.org/article/bf5eca59897f48d085a387a99592b627
Autor:
Michaela Shishmanova-Doseva, Jana Tchekalarova, Zlatina Nenchovska, Natasha Ivanova, Katerina Georgieva, Lyudmil Peychev
Publikováno v:
Folia Medica, Vol 62, Iss 4, Pp 723-729 (2020)
Introduction: Epilepsy and antiepileptic drugs can affect negatively the cognitive abilities of patients.Aim: The present study aimed to evaluate the effect of topiramate (TPM) and lacosamide (LCM) on the emotional and cognitive re-sponses in naive a
Externí odkaz:
https://doaj.org/article/62494b83f678445183ada28dfdc19269
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1425 (2022)
The endogenous hemorphins are bioactive peptides with activity on opioid receptors. They are extensively studied and summarized in numerous reviews. During the last decade, several research teams have synthesized, characterized, and pharmacologically
Externí odkaz:
https://doaj.org/article/6aedf1229e8e403a86f831c7fefbed2a
Autor:
Petar Todorov, Stela Georgieva, Jana Tchekalarova, Subaer Subaer, Petia Peneva, Hartati Hartati
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1251 (2022)
The emergence of diverse peptide derivatives has been due to constant efforts to find a specific peptide with pronounced biological activity for effective application as a therapeutic. Spinorphin-peptide products have been reported to possess various
Externí odkaz:
https://doaj.org/article/68c7448fd4d14b0ea4defd241f9333f1
Autor:
Stanislav Marchev, Pavlina Andreeva-Gateva, Roumiana Tzoneva, Slavina Surcheva, Alex Tzonev, Kalina Kamenova, Violina T. Angelova, Jana Tchekalarova, Mila Vlaskovska
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 33, Iss 1, Pp 98-107 (2019)
We have recently identified several aroylhydrazone-based molecular hybrids with antiseizure activity. We aimed to investigate the analgesic activity of these molecules further. Male ICR mice were injected intraperitoneally with the tested substances
Externí odkaz:
https://doaj.org/article/c2cd2ac56de845f3b7e5d8a8a2a7ba0c
Publikováno v:
Neurobiology of Disease, Vol 115, Iss , Pp 127-144 (2018)
Inflammatory signal molecules are suggested to be involved in the mechanism underlying comorbid depression in epilepsy. In the present study, we tested the hypothesis that the novel antidepressant agomelatine, a potent melatonin MT1 and MT2 receptor
Externí odkaz:
https://doaj.org/article/13138110e0cf4089b89293b343150327
Autor:
Jana Tchekalarova, Dimitrinka Atanasova, Zlatina Nenchovska, Milena Atanasova, Lidia Kortenska, Rumyana Gesheva, Nikolai Lazarov
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 1-14 (2017)
Recent studies about the novel antidepressant agomelatine, which is a mixed MT1 and MT2 melatonin receptor agonist and 5HT2C serotonin receptor antagonist possessing an anticonvulsant and neuroprotective action, suggest that it may have potential to
Externí odkaz:
https://doaj.org/article/a88c9399598846bf80d5ffe433037908