Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Jana Sopkova ‐ de Oliveira Santos"'
Autor:
Marc Farag, Charline Kieffer, Nicolas Guedeney, Anne Sophie Voisin-Chiret, Jana Sopkova-de Oliveira Santos
Publikováno v:
Molecules, Vol 28, Iss 13, p 5155 (2023)
X-linked inhibitor of apoptosis protein (XIAP) exercises its biological function by locking up and inhibiting essential caspase-3, -7 and -9 toward apoptosis execution. It is overexpressed in multiple human cancers, and it plays an important role in
Externí odkaz:
https://doaj.org/article/e94df2824aed43ca9b7361ce247907c4
Autor:
Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, Fanny Fontaine, Serge Perato, Sylvain Rault, Olivier Helynck, Fernando Arenzana-Seisdedos, Jana Sopkova-de Oliveira Santos, Bernard Lagane, Hélène Munier-Lehmann, Philippe Colin
Publikováno v:
Molecules, Vol 28, Iss 3, p 1156 (2023)
The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers. Here, we identified new CXCR4 ligands in the CERM
Externí odkaz:
https://doaj.org/article/2649592c172747d6a3a95d1a2c3b0285
Autor:
Quitterie Rochoux, Jana Sopkova-de Oliveira Santos, Christian Marcelli, Anne Rovelet-Lecrux, Virginie Chevallier, Jean-Jacques Dutheil, Sylvain Leclercq, Karim Boumédiene, Catherine Baugé, Juliette Aury-Landas
Publikováno v:
Biomolecules, Vol 11, Iss 10, p 1460 (2021)
The role of genetics in the development of osteoarthritis is well established but the molecular bases are not fully understood. Here, we describe a family carrying a germline mutation in COMP (Cartilage Oligomeric Matrix Protein) associated with thre
Externí odkaz:
https://doaj.org/article/5471e4bd379a473092fa578fdf786223
Autor:
Benjamin Guieu, Cedric Lecoutey, Rémi Legay, Audrey Davis, Jana Sopkova de Oliveira Santos, Cosimo Damiano Altomare, Marco Catto, Christophe Rochais, Patrick Dallemagne
Publikováno v:
Molecules, Vol 26, Iss 1, p 80 (2020)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated agains
Externí odkaz:
https://doaj.org/article/9be4c6aa85634db592c868ceb0d9f6e3
Autor:
Clément Vigier, Dimitri Fayolle, Hussein El Siblani, Jana Sopkova ‐ de Oliveira Santos, Frederic Fabis, Thomas Cailly, Emmanuelle Dubost
Publikováno v:
Angewandte Chemie International Edition. 61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d74366b32051f4e5a866796b28db59
https://doi.org/10.1002/anie.202208580
https://doi.org/10.1002/anie.202208580
Autor:
Christophe Rochais, Patrick Dallemagne, Jana Sopkova-de Oliveira Santos, Julien Lalut, Pauline Zipfel
Publikováno v:
Synthesis. 53:3799-3814
Aminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. To increase the chemical diversity in this series, the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold was explored.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bea733dade18251af18ba7e8a4e2946f
https://doi.org/10.1055/a-1523-1409
https://doi.org/10.1055/a-1523-1409
Autor:
François-Xavier Toublet, Cédric Lecoutey, Julien Lalut, Bérénice Hatat, Audrey Davis, Marc Since, Sophie Corvaisier, Thomas Freret, Jana Sopkova de Oliveira Santos, Sylvie Claeysen, Michel Boulouard, Patrick Dallemagne, Christophe Rochais
Publikováno v:
Molecules, Vol 24, Iss 15, p 2786 (2019)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease which is still poorly understood. The drugs currently used against AD, mainly acetylcholinesterase inhibitors (AChEI), are considered clinically insufficient and are responsible
Externí odkaz:
https://doaj.org/article/8a4bfc5092844dbebc8144c2bdd2f874
Autor:
Ronan Bureau, Mohammed Benabderrahmane, Jana Sopkova-de Oliveira Santos, Anne Sophie Voisin-Chiret
Publikováno v:
Journal of Chemical Information and Modeling. 60:3172-3187
In this study, we explored the structural dynamics of Mcl-1, an anti-apoptotic protein. On the basis of structural ensembles, the essential dynamics was extracted and showed two major axes of variability: a breathing motion at the binding interface a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42bc3857ca4d98d7ed05e02aa5e0498f
https://doi.org/10.1021/acs.jcim.0c00315
https://doi.org/10.1021/acs.jcim.0c00315
Autor:
Mohammed Benabderrahmane, Jana Sopkova-de Oliveira Santos, Anne Sophie Voisin-Chiret, Ronan Bureau
Publikováno v:
Journal of chemical information and modeling. 61(11)
Detection of cryptic pockets (hidden protein pockets) is a hot topic in structure-based drug discovery, especially for drugging the yet undruggable proteome. The experimental detection of cryptic pockets is still considered an expensive endeavor. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f3cfd1d1c7ccfeaec7a039df48e6a1
https://pubmed.ncbi.nlm.nih.gov/34748701
https://pubmed.ncbi.nlm.nih.gov/34748701
Autor:
Johanna Giovannini, Willy Smeralda, Marie Jouanne, Jana Sopkova-de Oliveira Santos, Marco Catto, Anne Sophie Voisin-Chiret
Publikováno v:
Drug discovery today. 27(5)
Tauopathies are neurodegenerative disorders associated with the accumulation of abnormal tubulin associated unit (tau) protein in the brain. Tau pathologies include a broad spectrum of diseases, with Alzheimer's disease (AD) being the most common tau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a053bb39d283a6da000beef6bb3d584b
https://pubmed.ncbi.nlm.nih.gov/35085785
https://pubmed.ncbi.nlm.nih.gov/35085785