Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jana Schwieger"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Neurotrophic factors (NTF) play key roles in the survival of neurons, making them promising candidates for therapy of neurodegenerative diseases. In the case of the inner ear, sensorineural hearing loss (SNHL) is characterized over time by a degenera
Externí odkaz:
https://doaj.org/article/991d7ca42ed0471e987d560d457d71fa
Autor:
Verena Scheper, Melanie Schmidtheisler, Florian Lasch, Heiko von der Leyen, Armin Koch, Jana Schwieger, Andreas Büchner, Anke Lesinski-Schiedat, Thomas Lenarz
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background The standard therapy for patients suffering from sensorineural hearing loss is cochlear implantation. The insertion of the electrode array into the cochlea, with potential mechanical trauma and the presence of this foreign body in
Externí odkaz:
https://doaj.org/article/0e03aba5689f4ab3943e9853368e523a
Autor:
Farnaz Matin-Mann, Ziwen Gao, Jana Schwieger, Martin Ulbricht, Vanessa Domsta, Stefan Senekowitsch, Werner Weitschies, Anne Seidlitz, Katharina Doll, Meike Stiesch, Thomas Lenarz, Verena Scheper
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1242 (2022)
Postoperative restenosis in patients with external ear canal (EEC) atresia or stenosis is a common complication following canaloplasty. Our aim in this study was to explore the feasibility of using a three dimensionally (3D)-printed, patient-individu
Externí odkaz:
https://doaj.org/article/a23ea856672b4fa4b1f865d988de10b1
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 589 (2022)
Cochlear hair cell damage and spiral ganglion neuron (SGN) degeneration are the main causes of sensory neural hearing loss. Cochlear implants (CIs) can replace the function of the hair cells and stimulate the SGNs electrically. The condition of the S
Externí odkaz:
https://doaj.org/article/5c23924b7f6c435e83d218911b996bc3
Autor:
Jana Schwieger, Anika Hamm, Michael M. Gepp, André Schulz, Andrea Hoffmann, Thomas Lenarz, Verena Scheper
Publikováno v:
Journal of Tissue Engineering, Vol 11 (2020)
The cochlear implant outcome is possibly improved by brain-derived neurotrophic factor treatment protecting spiral ganglion neurons. Implantation of genetically modified mesenchymal stem cells may enable the required long-term brain-derived neurotrop
Externí odkaz:
https://doaj.org/article/e38a5a6e280c4ce69be67c4e7bb61741
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1896 (2021)
Dexamethasone is widely used in preclinical studies and clinical trials to treat inner ear disorders. The results of those studies vary widely, maybe due to the different dexamethasone formulations used. Laboratory (lab) and medical grade (med) dexam
Externí odkaz:
https://doaj.org/article/cecf0fde12874e23a6167b7289a1dc51
Autor:
Verena Scheper, Andrea Hoffmann, Michael M. Gepp, André Schulz, Anika Hamm, Christoph Pannier, Peter Hubka, Thomas Lenarz, Jana Schwieger
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Background: The success of a cochlear implant (CI), which is the standard therapy for patients suffering from severe to profound sensorineural hearing loss, depends on the number and excitability of spiral ganglion neurons (SGNs). Brain-derived neuro
Externí odkaz:
https://doaj.org/article/fa4f2b01558148c7b323c541a1c5c266
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133680 (2015)
The functionality of cochlear implants (CI) depends, among others, on the number and excitability of surviving spiral ganglion neurons (SGN). The spatial separation between the SGN, located in the bony axis of the inner ear, and the CI, which is inse
Externí odkaz:
https://doaj.org/article/43b1c159f9b74eba97a2b59a19339eda
Publikováno v:
Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 775-778 (2021)
Inner ear trauma caused by cochlear implantation is a severe clinical problem. It was shown that an electrode alginate coating can reduce the insertion forces in vitro. The grade of the alginate viscosity can be adjusted by using different metal ions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750bcddafc27f0142ac408614a49b2aa
https://doaj.org/article/f18d4b90d22645c9ada84f1bcf3c6806
https://doaj.org/article/f18d4b90d22645c9ada84f1bcf3c6806