Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jana Schirmeyer"'
Autor:
Jana Schirmeyer, Thomas Eick, Eckhard Schulz, Sabine Hummert, Christian Sattler, Ralf Schmauder, Klaus Benndorf
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010376 (2022)
Cyclic nucleotide-gated (CNG) ion channels of olfactory sensory neurons contain three types of homologue subunits, two CNGA2 subunits, one CNGA4 subunit and one CNGB1b subunit. Each subunit carries an intracellular cyclic nucleotide binding domain (C
Externí odkaz:
https://doaj.org/article/ebc7e5e9eecf4c9593cc5cb6b7fb22cd
Autor:
Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118
Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ee041afd71a562ab3c4251498b6ca
http://europepmc.org/articles/PMC8325370
http://europepmc.org/articles/PMC8325370
Autor:
Nisa Wongsamitkul, Thomas Eick, Eckhard Schulz, Thomas Zimmer, Ralf Schmauder, Jana Schirmeyer, Sabine Hummert, Vasilica Nache, Klaus Benndorf
Publikováno v:
Scientific Reports. 8
Scientific Reports 6; Article number: 20974; published online: 09 February 2016; updated: 28 June 2018 The Acknowledgements section in this Article is incomplete. “We would like to thank G. Ditze, G. Sammler, F. Horn, M. Händel, K. Schoknecht, S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c658a870ad141dfca37cc05a8ef80a5
https://doi.org/10.1038/srep47001
https://doi.org/10.1038/srep47001
Autor:
Jana Schirmeyer, Enrico Leipold, Christian Mawrin, Matthias Platzer, Karol Szafranski, Stefan H. Heinemann
Publikováno v:
Channels, 8(3):210–215
The voltage-gated sodium channel Na(V)1.8 (encoded by SCN10A) is predominantly expressed in dorsal root ganglia(DRG) and plays a critical role in pain perception. We analyzed SCN10A transcripts isolated from human DRGs using deep sequencing and found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c30a7db748fde94630bd4bbc0864b11
https://doi.org/10.4161/chan.28146
https://doi.org/10.4161/chan.28146
Autor:
Enrico Leipold, Stefan H. Heinemann, René Markgraf, Oliver Hartley, Jana Schirmeyer, Marianne Paolini-Bertrand
Publikováno v:
British Journal of Pharmacology, Vol. 167, No 3 (2012) pp. 576-86
BACKGROUND AND PURPOSE Voltage-gated sodium channels (Na(V) channels) are key players in the generation and propagation of action potentials, and selective blockade of these channels is a promising strategy for clinically useful suppression of electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301aa490031217cb0f1423bded86ea00
https://doi.org/10.1111/j.1476-5381.2012.02004.x
https://doi.org/10.1111/j.1476-5381.2012.02004.x
Autor:
Diana Imhof, Jana Schirmeyer, Alesia Miloslavina, Michael Kijas, René Markgraf, Stefan H. Heinemann, Enrico Leipold
Publikováno v:
Neuropharmacology. 61:105-111
Voltage-gated sodium channels (Na(V) channels) play a pivotal role in neuronal excitability; they are specifically targeted by μ-conotoxins from the venom of marine cone snails. These peptide toxins bind to the outer vestibule of the channel pore th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bc7b9496c6f072d11aa2791d798aec
https://doi.org/10.1016/j.neuropharm.2011.03.008
https://doi.org/10.1016/j.neuropharm.2011.03.008
Autor:
Stefan H. Heinemann, Jana Schirmeyer, Karol Szafranski, Enrico Leipold, Matthias Platzer, Christian Mawrin
Publikováno v:
Journal of Molecular Neuroscience. 41:310-314
The voltage-gated sodium channel subtype Na(V)1.8 (SCN10A) is exclusively expressed in dorsal root ganglia (DRG) and plays a critical role in pain perception. We isolated mRNA from human, rat, and mouse DRGs and screened for alternatively spliced iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7d6e5e6c2fd9a61a9750cc5a3d5faf
https://doi.org/10.1007/s12031-009-9315-3
https://doi.org/10.1007/s12031-009-9315-3
Autor:
Jana Schirmeyer, Toshinori Hoshi, Martin Schink, Stefan H. Heinemann, Enrico Leipold, Roland Schönherr
Dorsal root ganglion (DRG) neurons are important relay stations between the periphery and the central nervous system and are essential for somatosensory signaling. Reactive species are produced in a variety of physiological and pathophysiological con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5264d4c6d8cf181549538f9b5a485d9
https://europepmc.org/articles/PMC5165275/
https://europepmc.org/articles/PMC5165275/
Autor:
Jana Schirmeyer, Sabine Hummert, Thomas Zimmer, Eckhard Schulz, Ralf Schmauder, Vasilica Nache, Klaus Benndorf, Thomas Eick, Nisa Wongsamitkul
Publikováno v:
Biophysical Journal. 108:192a
Cyclic nucleotide-gated (CNG) channels mediate signal transduction in photoreceptors and olfactory cells. Wild-type olfactory CNG channels are composed of three types of subunits, CNGA2, CNGA4, and CNGB1b. Out of these only CNGA2 subunits can form fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe8dc94c9f6e20ddd4fdb30c94c0822
https://doi.org/10.1016/j.bpj.2014.11.1063
https://doi.org/10.1016/j.bpj.2014.11.1063
Publikováno v:
Biophysical Journal. (2):290a
Cyclic nucleotide-gated (CNG) ion channels, key components in the sensory transduction of vision and odour, are non-selective cation channels, activated by the binding of cAMP or cGMP. Native CNG channels of olfactory sensory neurons are heterotetram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d338393ecc4f090eed64aa743397ee3