Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jana Raynor"'
Autor:
Jana Raynor, Adora Lin, Sarah A. Hummel, Kristin Lampe, Michael Jordan, Kasper Hoebe, David A. Hildeman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Increasing evidence points to a key role for NK cells in controlling adaptive immune responses. In studies examining the role of CD1d on CD4+ T cell responses, we found that a line of CD1d-deficient mice on the C57BL/6J background had a homozygous 12
Externí odkaz:
https://doaj.org/article/a73f170725f04db8a4eb0e4e13944ccd
Autor:
Maha Almanan, Jana Raynor, Allyson Sholl, Mei Wang, Claire Chougnet, Rhonda D Cardin, David A Hildeman
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006507 (2017)
Cytomegalovirus (CMV) causes a persistent, lifelong infection. CMV persists in a latent state and undergoes intermittent subclinical viral reactivation that is quelled by ongoing T cell responses. While T cells are critical to maintain control of inf
Externí odkaz:
https://doaj.org/article/044cf3d209704fe59f1edf663fbfbbf8
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
T cells play pivotal roles in shaping host immune responses in infectious diseases, autoimmunity, and cancer. The activation of T cells requires immune and growth factor-derived signals. However, alterations in nutrients and metabolic signals tune T
Externí odkaz:
https://doaj.org/article/b20a4632d2c74a5e864c72ed6fe0e87b
Autor:
George S. Deepe, Jana Raynor, Jennifer T. Ingram, Ireti Ogunsulire, Alexander L. Dent, Allan J. Zajac, Sarah A. Hummel, Markus M. Xie, Christoph Hölscher, Senad Divanovic, Shibabrata Mukherjee, Claire Chougnet, Sing Sing Way, Harinder Singh, David A. Hildeman, Anna Malyshkina, Emily R. Miraldi, Ankur Saini, Theresa Alenghat, Maha Almanan
Publikováno v:
Science Advances
Elevated IL-10 in aged mice suppresses immune responses and has implications for vaccine nonresponsiveness in the elderly.
Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to
Aging results in profound immune dysfunction, resulting in the decline of vaccine responsiveness previously attributed to
Autor:
Kun-Po Li, David A. Hildeman, Maha Almanan, Rebekah Karns, Senad Divanovic, Claire A. Chougnet, Jana Raynor
Publikováno v:
The Journal of Immunology. 195:944-952
Regulatory T cells (Tregs), a subset of CD4+ T cells, dramatically accumulate with age in humans and mice and contribute to age-related immune suppression. Recently, we showed that a majority of accumulating Tregs in aged mice expressed low levels of
Autor:
Allyson Sholl, Celine S. Lages, David R. Plas, David A. Hildeman, Pamela J. Fink, Pulak Tripathi, Claire A. Chougnet, Jana Raynor
Publikováno v:
The Journal of Immunology. 186:156-163
We have previously shown that regulatory T cells (Treg) accumulate dramatically in aged animals and negatively impact the ability to control persistent infection. However, the mechanisms underlying the age-dependent accrual of Treg remain unclear. In
Autor:
Mei Wang, Maha Almanan, Allyson Sholl, Rhonda D. Cardin, David A. Hildeman, Claire A. Chougnet, Jana Raynor
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006507 (2017)
PLoS Pathogens
PLoS Pathogens
Cytomegalovirus (CMV) causes a persistent, lifelong infection. CMV persists in a latent state and undergoes intermittent subclinical viral reactivation that is quelled by ongoing T cell responses. While T cells are critical to maintain control of inf
Autor:
Maha A Almanan, Jana Raynor, Claire Chougnet, Nathan Salamonis, Surya Amarachintha, Kris Steinbrecher, David A Hildeman
Publikováno v:
The Journal of Immunology. 198:154.10-154.10
Type 1 regulatory T cells (Tr1) are a unique population of CD4+ Foxp3− cells that express high levels of IL-10, and have been defined based on their expression of CD49b and LAG-3. Despite the critical roles played by Tr1 cells in controlling T cell
Autor:
Sema Kurtulus, David A. Hildeman, Marc Pellegrini, Kun-Po Li, Toe J, Jana Raynor, Pulak Tripathi, Allyson Sholl
During the effector CD8+ T-cell response, transcriptional differentiation programs are engaged that promote effector T cells with varying memory potential. Although these differentiation programs have been used to explain which cells die as effectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef8a8fc5b59273ee8e12b7350393dfe
https://europepmc.org/articles/PMC4262773/
https://europepmc.org/articles/PMC4262773/