Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jana Mládková"'
Publikováno v:
Biomedical Chromatography. 27:111-121
We optimized and validated a rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of six metabolites of homocysteine metabolism: homocysteine, methionine, cysteine, S-adenosylmethionine, S-adenos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4e49373f53f71f9014dcdba0118fa46
https://doi.org/10.1002/bmc.2755
https://doi.org/10.1002/bmc.2755
Autor:
Jana, Mládková, Jana, Hladílková, Carrie E, Diamond, Katherine, Tryon, Kazuhiro, Yamada, Timothy A, Garrow, Pavel, Jungwirth, Markos, Koutmos, Jiří, Jiráček
Publikováno v:
Proteins. 82(10)
Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. This reaction supports S-adenosylmethionine biosynthesis, which is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::251800115df32fd3df3e45549ea69844
https://pubmed.ncbi.nlm.nih.gov/24895213
https://pubmed.ncbi.nlm.nih.gov/24895213
Autor:
Jana Mládková, Martina Chrudinová, Marek Kořínek, Zuzana Demianová, Irena Selicharová, Jiří Jiráček
Publikováno v:
Biochimica et biophysica acta. 1834(8)
Both cardiovascular disease and liver injury are major public health issues. Hyperhomocysteinemia has been linked to cardiovascular diseases, and defects in methyl group metabolism, often resulting in hyperhomocysteinemia, are among the key molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc67939c8b24b58d159a53ca5e27719
https://pubmed.ncbi.nlm.nih.gov/23689031
https://pubmed.ncbi.nlm.nih.gov/23689031
Autor:
Zuzana Demianová, Václav Vaněk, Jana Mládková, Timothy A. Garrow, Jiří Jiráček, Tomáš Elbert, Miloš Buděšínský
Publikováno v:
Journal of medicinal chemistry. 55(15)
Betaine-homocysteine S-methyltransferase 2 (BHMT-2) catalyzes the transfer of a methyl group from S-methylmethionine to l-homocysteine, yielding two molecules of l-methionine. It is one of three homocysteine methyltransferases in mammals, but its ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf4570b58db56ca21d6984becdd2042
https://pubmed.ncbi.nlm.nih.gov/22775318
https://pubmed.ncbi.nlm.nih.gov/22775318
Autor:
Marek, Kořínek, Václav, Sístek, Jana, Mládková, Petr, Mikeš, Jiří, Jiráček, Irena, Selicharová
Publikováno v:
Biomedical chromatography : BMC. 27(1)
We optimized and validated a rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of six metabolites of homocysteine metabolism: homocysteine, methionine, cysteine, S-adenosylmethionine, S-adenos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa7376e3c083826c9dac9b44f66e3d0f
https://pubmed.ncbi.nlm.nih.gov/22653757
https://pubmed.ncbi.nlm.nih.gov/22653757
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 449 (2010)
BMC Cancer
BMC Cancer
Background Transformed phenotypes are common to cell lines derived from various cancers. Proteome profiling is a valuable tool that may reveal uncharacteristic cell phenotypes in transformed cells. Changes in expression of glutathione S-transferases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad235bb393591301786b341529a34824
http://www.biomedcentral.com/1471-2407/10/449
http://www.biomedcentral.com/1471-2407/10/449
Autor:
Milos Budesínský, Vaclav Vanek, Ivona Hančlová, Markos Koutmos, Miloslav Sanda, Ivan Rosenberg, Jiri Brynda, Jana Mládková, Petra Kabeleová, Timothy A. Garrow, Jiri Jiracek, Milan Kozisek
Publikováno v:
Journal of medicinal chemistry. 52(12)
Betaine-homocysteine S-methyltransferase (BHMT) catalyzes the transfer of a methyl group from betaine to l-homocysteine, yielding dimethylglycine and l-methionine. In this study, we prepared a new series of BHMT inhibitors. The inhibitors were design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0f22e380dc5336ea6cebabbdf54ba3
https://pubmed.ncbi.nlm.nih.gov/19534555
https://pubmed.ncbi.nlm.nih.gov/19534555
Autor:
Zuzana Demianová, Jana Mládková, Miloš Buděšínský, Václav Vaněk, Timothy A. Garrow, Tomáš Elbert, Jiří Jiráček
Publikováno v:
Journal of Medicinal Chemistry. 55:8974-8974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21d2930895e07bb93d397b6120a7d45e
https://doi.org/10.1021/jm3013079
https://doi.org/10.1021/jm3013079
Autor:
Václav Vaněk, Miloš Buděšínský, Petra Kabeleová, Miloslav Šanda, Milan Kožíšek, Ivona Hančlová, Jana Mládková, Jiří Brynda, Ivan Rosenberg, Markos Koutmos, Timothy A. Garrow, Jiří Jiráček
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 12, p3652-3665, 14p
Autor:
Jana Mládková, Aruna Vashishta, Irena Selicharová, Martin Fusek, Vaclav Vetvicka, Jiri Jiracek, Sujata Saraswat Ohri, Miloslav Sanda
Publikováno v:
Scopus-Elsevier
Human MDA-MB-231 derived breast cancer cell lines 1833 and 4175 have different metastatic potentials in terms of their tissue tropisms and aggressiveness. Cell line 1833 is specifically metastatic to the bone. The highly aggressive cell line 4175 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5418394f0d9e368496a24db5c0f49a24
http://www.scopus.com/inward/record.url?eid=2-s2.0-43749106948&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-43749106948&partnerID=MN8TOARS
