Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jana Maixnerova"'
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 696 (2023)
The synthetic analogs of regulatory peptides radiolabeled with adequate radionuclides are perspective tools in nuclear medicine. However, undesirable uptake and retention in the kidney limit their application. Specific in vitro methods are used to ev
Externí odkaz:
https://doaj.org/article/d71df960877b48b6b4e2559bce6d6f86
Publikováno v:
Cells, Vol 11, Iss 19, p 2974 (2022)
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role in drug metabolism and elimination, but also promotes tumor growth, drug resistance, and met
Externí odkaz:
https://doaj.org/article/de607d68ad2e43dbb50e089162525b94
Autor:
Josef Skoda, Klara Dohnalova, Karel Chalupsky, Aaron Stahl, Markus Templin, Jana Maixnerova, Stanislav Micuda, Lars Grøntved, Albert Braeuning, Petr Pavek
Publikováno v:
Skoda, J, Dohnalova, K, Chalupsky, K, Stahl, A, Templin, M, Maixnerova, J, Micuda, S, Grøntved, L, Braeuning, A & Pavek, P 2022, ' Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice ', Biochemical Pharmacology, vol. 197, 114905 . https://doi.org/10.1016/j.bcp.2021.114905
Biochemical pharmacology
Biochemical pharmacology
The constitutive androstane receptor (CAR) controls xenobiotic clearance, regulates liver glucose, lipid metabolism, and energy homeostasis. These functions have been mainly discovered using the prototypical mouse-specific CAR ligand TCPOBOP in wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ea4d97bdea4366ddc6d0d793fba9ec
https://portal.findresearcher.sdu.dk/da/publications/063b1649-44df-41de-b110-b8485051d696
https://portal.findresearcher.sdu.dk/da/publications/063b1649-44df-41de-b110-b8485051d696
Autor:
Klára Konečná, Adéla Diepoltová, Pavlína Holmanová, Ondřej Jand’ourek, Marcela Vejsová, Barbora Voxová, Pavel Bárta, Jana Maixnerová, František Trejtnar, Marta Kučerová-Chlupáčová
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The greatest threat and medicinal impact within gram-positive pathogens are posed by two bacterial genera, Staphylococcus and Enterococcus. Chalcones have a wide range of biological activities and are recognized as effective templates in medicinal ch
Externí odkaz:
https://doaj.org/article/4da402bc3a974b44916136f26d267479
Autor:
Václav Pflégr, Jana Maixnerová, Jiřina Stolaříková, Adrián Pál, Jana Korduláková, František Trejtnar, Jarmila Vinšová, Martin Krátký
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1302 (2021)
The combination of two active scaffolds into one molecule represents a proven approach in drug design to overcome microbial drug resistance. We designed and synthesized more lipophilic esters of 2-(2-isonicotinoylhydrazineylidene)propanoic acid, obta
Externí odkaz:
https://doaj.org/article/2ccda21cb08d4267811d33b82546ab2f
Autor:
Martin Krátký, Šárka Štěpánková, Klára Konečná, Katarína Svrčková, Jana Maixnerová, Markéta Švarcová, Ondřej Janďourek, František Trejtnar, Jarmila Vinšová
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1229 (2021)
A series of thirty-one hydrazones of aminoguanidine, nitroaminoguanidine, 1,3-diaminoguanidine, and (thio)semicarbazide were prepared from various aldehydes, mainly chlorobenzaldehydes, halogenated salicylaldehydes, 5-nitrofurfural, and isatin (yield
Externí odkaz:
https://doaj.org/article/fcac6a015aab4e599dcb6c73d4149617