Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jana L. Mooster"'
Autor:
Jossef F Osborn, Samuel J Hobbs, Jana L Mooster, Tahsin N Khan, Augustus M Kilgore, Jake C Harbour, Jeffrey C Nolz
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007633 (2019)
Memory CD8+ T cells in the circulation rapidly infiltrate non-lymphoid tissues following infection and provide protective immunity in an antigen-specific manner. However, the subsequent fate of memory CD8+ T cells after entering non-lymphoid tissues
Externí odkaz:
https://doaj.org/article/3d83680066fd4304be459b61fd72a3bb
Autor:
Adam G W Matthews, Christine E Briggs, Keiichi Yamanaka, Trudy N Small, Jana L Mooster, Francisco A Bonilla, Marjorie A Oettinger, Manish J Butte
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121489 (2015)
Omenn syndrome is a primary immunodeficiency disorder, featuring susceptibility to infections and autoreactive T cells and resulting from defective genomic rearrangement of genes for the T cell and B cell receptors. The most frequent etiologies are h
Externí odkaz:
https://doaj.org/article/e1ffde0e4f2e44db9b5eb5986ea137b8
Publikováno v:
The Journal of Experimental Medicine
CD8+ T cells activated during viral infection migrate to infected skin in an antigen-independent manner. Local recognition of antigens drives the differentiation into Trm CD8+ T cells.
Tissue-resident memory (Trm) CD8+ T cells are functionally d
Tissue-resident memory (Trm) CD8+ T cells are functionally d
Autor:
Haifa H. Jabara, Severine Le Bras, Balthasar A. Heesters, Raif S. Geha, Jana L. Mooster, Oliver T. Burton, Hamid Mattoo, Claire Galand, Michel J. Massaad, John P. Manis, Juhan Yoon
Publikováno v:
The Journal of Experimental Medicine
Mooster et al. created a knock-in mouse harboring a mutation (S32I) in IκBα that has been identified in a patient with ectodermal dysplasia with immunodeficiency. The mice are characterized by defective architectural cell function; they lack lymph
Autor:
Jossef F. Osborn, Samuel J. Hobbs, Michael W. Munks, Jeffrey C. Nolz, Jana L. Mooster, John T. Harty, Ann B. Hill, Conrad Barry
Publikováno v:
Science Immunology. 2
Trafficking of memory CD8+ T cells out of the circulation is essential to provide protective immunity against intracellular pathogens in non-lymphoid tissues. However, the molecular mechanisms that dictate the trafficking potential of diverse memory
Autor:
Francisco A. Bonilla, Christine Briggs, Marjorie A. Oettinger, Trudy N. Small, Jana L. Mooster, Keiichi Yamanaka, Manish J. Butte, Adam G. W. Matthews
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0121489 (2015)
PloS one, vol 10, iss 4
PLoS ONE, Vol 10, Iss 4, p e0121489 (2015)
PloS one, vol 10, iss 4
Omenn syndrome is a primary immunodeficiency disorder, featuring susceptibility to infections and autoreactive T cells and resulting from defective genomic rearrangement of genes for the T cell and B cell receptors. The most frequent etiologies are h
Autor:
Elizabeth L. Holbrook, Ursula Schulze-Gahmen, Maurice J. Bessman, WenLian Xu, Stephen R. Holbrook, Wasantha Ranatunga, Emma Hill, Jana L. Mooster, Steven E. Brenner
Publikováno v:
Journal of Molecular Biology. 339:103-116
We have determined the crystal structure, at 1.4 A, of the Nudix hydrolase DR1025 from the extremely radiation resistant bacterium Deinococcus radiodurans. The protein forms an intertwined homodimer by exchanging N-terminal segments between chains. W
Publikováno v:
The Journal of Immunology. 196:119.20-119.20
Following successful vaccination or pathogen clearance, recently activated CD8+ T cells that survive contraction differentiate into long-lived memory populations and provide host protection against re-infection. We have previously demonstrated that m
Autor:
Alessandra Simonetti, Luigi D. Notarangelo, Jana L. Mooster, Caterina Cancrini, Maria Luisa Romiti, Raif S. Geha, Gigliola Di Matteo, Paolo Rossi, Silvia Di Cesare, Douglas R. McDonald
Publikováno v:
Journal of Allergy and Clinical Immunology. 126:127-132.e7
Background Nuclear factor-κB (NF-κB) is a key transcription factor that regulates both innate and adaptive immunity as well as ectodermal development. Mutations in the coding region of the IκB kinase γ/NF-κB essential modifier (NEMO) gene cause