Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest.

Autor: Jana Lützkendorf, Elisabeth Wieduwild, Katrin Nerger, Nina Lambrecht, Hans-Joachim Schmoll, Carsten Müller-Tidow, Lutz Peter Müller

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169921 (2017)

Adult stem cells including multipotent mesenchymal stromal cells (MSC) acquire a high amount of DNA-damage due to their prolonged lifespan. MSC may exert specific mechanisms of resistance to avoid loss of functional activity. We have previously shown

Externí odkaz: https://doaj.org/article/86eb2debf2014e78809892cf1d7b7c7d

IGHV1-69 BCRs with virus-neutralizing mutations show lymphoma-like transcriptomes in patients with chronic HCV infection

Autor: Christoph Schultheiß, Edith Willscher, Lisa Paschold, Christin Ackermann, Moritz Escher, Rebekka Scholz, Maximilian Knapp, Jana Lützkendorf, Lutz Müller, Julian Schulze zur Wiesch, Mascha Binder

Chronic hepatitis C virus (HCV) infection leads to a complex interplay with adaptive immune cells that may result in cryoglobulinemia or lymphoma. Although direct-acting antiviral (DAA) therapy has decreased the incidence of severe liver damage, its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33665026cf6c17deab9e9cc8472faa13
https://doi.org/10.21203/rs.3.rs-2719495/v1

MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models

Autor: Sara, Werner, Jana, Lützkendorf, Thomas, Müller, Lutz P, Müller, Guido, Posern

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

Tumour growth and metastatic colonization is strongly influenced by the tumour stroma, including cancer-associated fibroblasts (CAF). Multipotent mesenchymal stromal cells (MSC) are a possible source of CAF following myofibroblastic differentiation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7835ae578d58b8c56532ff8daa20b73d
http://link.springer.com/article/10.1038/s41598-019-48142-z

Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest

Autor: Nina Lambrecht, Hans-Joachim Schmoll, Carsten Müller-Tidow, Jana Lützkendorf, Lutz P. Müller, Elisabeth Wieduwild, Katrin Nerger

Publikováno v: PLoS ONE
PLoS ONE, 2017, 12 (1), pp.e0169921. ⟨10.1371/journal.pone.0169921⟩
PLoS ONE, Vol 12, Iss 1, p e0169921 (2017)
PLoS ONE, Public Library of Science, 2017, 12 (1), pp.e0169921. ⟨10.1371/journal.pone.0169921⟩

International audience; Adult stem cells including multipotent mesenchymal stromal cells (MSC) acquire a high amount of DNA-damage due to their prolonged lifespan. MSC may exert specific mechanisms of resistance to avoid loss of functional activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c8902227e5b28511b931108e2227cc
https://hal.science/hal-01996187

Multipotent mesenchymal stromal cells promote tumor growth in distinct colorectal cancer cells by a β1-integrin-dependent mechanism

Autor: Miriam, Widder, Jana, Lützkendorf, Henrike, Caysa, Susanne, Unverzagt, Claudia, Wickenhauser, Ralf A, Benndorf, Hans-Joachim, Schmoll, Carsten, Müller-Tidow, Thomas, Müller, Lutz P, Müller

Publikováno v: International journal of cancer. 138(4)

Tumor-stroma interactions play an essential role in the biology of colorectal carcinoma (CRC). Multipotent mesenchymal stromal cells (MSC) may represent a pivotal part of the stroma in CRC, but little is known about the specific interaction of MSC wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eddabe21ef6c7118a69e4234af9df850
https://pubmed.ncbi.nlm.nih.gov/26356035