Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jana K Rundle"'
Autor:
Anubha Mahajan, Xueling Sim, Hui Jin Ng, Alisa Manning, Manuel A Rivas, Heather M Highland, Adam E Locke, Niels Grarup, Hae Kyung Im, Pablo Cingolani, Jason Flannick, Pierre Fontanillas, Christian Fuchsberger, Kyle J Gaulton, Tanya M Teslovich, N William Rayner, Neil R Robertson, Nicola L Beer, Jana K Rundle, Jette Bork-Jensen, Claes Ladenvall, Christine Blancher, David Buck, Gemma Buck, Noël P Burtt, Stacey Gabriel, Anette P Gjesing, Christopher J Groves, Mette Hollensted, Jeroen R Huyghe, Anne U Jackson, Goo Jun, Johanne Marie Justesen, Massimo Mangino, Jacquelyn Murphy, Matt Neville, Robert Onofrio, Kerrin S Small, Heather M Stringham, Ann-Christine Syvänen, Joseph Trakalo, Goncalo Abecasis, Graeme I Bell, John Blangero, Nancy J Cox, Ravindranath Duggirala, Craig L Hanis, Mark Seielstad, James G Wilson, Cramer Christensen, Ivan Brandslund, Rainer Rauramaa, Gabriela L Surdulescu, Alex S F Doney, Lars Lannfelt, Allan Linneberg, Bo Isomaa, Tiinamaija Tuomi, Marit E Jørgensen, Torben Jørgensen, Johanna Kuusisto, Matti Uusitupa, Veikko Salomaa, Timothy D Spector, Andrew D Morris, Colin N A Palmer, Francis S Collins, Karen L Mohlke, Richard N Bergman, Erik Ingelsson, Lars Lind, Jaakko Tuomilehto, Torben Hansen, Richard M Watanabe, Inga Prokopenko, Josee Dupuis, Fredrik Karpe, Leif Groop, Markku Laakso, Oluf Pedersen, Jose C Florez, Andrew P Morris, David Altshuler, James B Meigs, Michael Boehnke, Mark I McCarthy, Cecilia M Lindgren, Anna L Gloyn, T2D-GENES consortium and GoT2D consortium
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004876 (2015)
Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have identified common variant signals which explain 4.8% and 1.2% of trait variance, respectively. It is hypothesized that low-frequency and rare variants could contrib
Externí odkaz:
https://doaj.org/article/cec1ab88480748b08bff91f2f1d31386
In addition to the directly mutagenic effects of energy deposition in DNA, ionizing radiation is associated with a variety of untargeted and delayed effects that result in ongoing bone marrow damage. Delayed effects are genotype dependent with CBA/Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cae8a21e81edb8201139b085986abfa
https://doi.org/10.1158/0008-5472.c.6497747.v1
https://doi.org/10.1158/0008-5472.c.6497747.v1
Supplementary Table 1 from Indirect Macrophage Responses to Ionizing Radiation: Implications for Genotype-Dependent Bystander Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d475ca46db25a9312f8520e8bf2e73a
https://doi.org/10.1158/0008-5472.22375238.v1
https://doi.org/10.1158/0008-5472.22375238.v1
Supplementary Table 2 from Indirect Macrophage Responses to Ionizing Radiation: Implications for Genotype-Dependent Bystander Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3399a718580a6dedcb0fab8ab0d5cf1c
https://doi.org/10.1158/0008-5472.22375235
https://doi.org/10.1158/0008-5472.22375235
Supplementary Table 3 from Indirect Macrophage Responses to Ionizing Radiation: Implications for Genotype-Dependent Bystander Signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bada2e4d84e737d1b97567b78fac9cd
https://doi.org/10.1158/0008-5472.22375232.v1
https://doi.org/10.1158/0008-5472.22375232.v1
Autor:
Pål R. Njølstad, Kevin Colclough, Anders Molven, Sameena Nawaz, Anna L. Gloyn, Sian Ellard, Anubha Mahajan, Jana K. Rundle, Neelam Hassanali, Laeya A. Najmi, Amanda J. Bennett, Mark I. McCarthy, Ingvild Aukrust, Alba Kaci, Sara Althari, Lise Bjørkhaug, Janne Molnes, Timme van der Lugt
Publikováno v:
American Journal of Human Genetics
American Journal of Human Genetics, 107(4), 670-682. Cell Press
American Journal of Human Genetics, 107(4), 670-682. Cell Press
Exome sequencing in diabetes presents a diagnostic challenge because depending on frequency, functional impact, and genomic and environmental contexts, HNF1A variants can cause maturity-onset diabetes of the young (MODY), increase type 2 diabetes ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6b48115fc98c03391f2e9ae6d33a62
https://hdl.handle.net/11250/2684674
https://hdl.handle.net/11250/2684674
Autor:
Wieland Kiess, Josée Dupuis, Yingchang Lu, Yii-Der Ida Chen, Sara M. Willems, George Dedoussis, Frida Renström, Carolina Medina-Gomez, Tamara B. Harris, Cramer Christensen, Audrey Y. Chu, Nicola L. Beer, Emil V. R. Appel, Niels Grarup, Fredrik Karpe, Mark I. McCarthy, Yuning Chen, Veikko Salomaa, Sylvain Sebert, Richard A. Jensen, Joel N. Hirschhorn, Lars Lind, Jocelyn E. Manning Fox, Caroline Hayward, Patrick E. MacDonald, Matti Uusitupa, Stavroula Kanoni, Carola Marzi, Kenneth Rice, Leslie A. Lange, Ken Sin Lo, Jennifer L. Asimit, Nisa M. Maruthur, Leonard Lipovich, James S. Floyd, Rona J. Strawbridge, Magdalena Zoledziewska, Anne Raimondo, Robert Sladek, Alexandra I. F. Blakemore, Hugoline G. de Haan, Danish Saleheen, Ji Chen, Neil Robertson, Ching-Yu Cheng, Heiner Boeing, Min A. Jhun, Marjo-Riitta Järvelin, Anubha Mahajan, Rainer Rauramaa, Satu Männistö, Paul M. Ridker, Ivan Brandslund, Hester M. den Ruijter, Tien Yin Wong, Alison D. Murray, Jaakko Tuomilehto, Xueling Sim, Igor Rudan, Martijn van de Bunt, Jin Li, Marit E. Jørgensen, Marie-France Hivert, Archie Campbell, Salman M. Tajuddin, Pekka Jousilahti, Lawrence F. Bielak, Juan P. Fernandez, Eleanor Wheeler, Alan B. Zonderman, Anne Clark, Lori L. Bonnycastle, Kurt Lohman, Peter Kovacs, Jung-Jin Lee, Jennifer Wessel, Wesam A Alhejily, Gerard Pasterkamp, John M. Starr, Ping An, Matthias Blüher, Jian'an Luan, Hanieh Yeghootkar, Jakob Stokholm, Michael Roden, Blair H. Smith, Johanna Jakobsdottir, Franco Giulianini, Andrianos M. Yiorkas, Hidetoshi Kitajima, Michael A. Province, Aliki-Eleni Farmaki, Kerrin S. Small, Juha Saltevo, Robert A. Scott, Alena Stančáková, Gaëlle Marenne, Asif Rasheed, Ruth J. F. Loos, David J. Porteous, Cecilia M. Lindgren, Inês Barroso, Gail Davies, Anna L. Gloyn, Shuai Wang, Paul Redmond, Xiuqing Guo, Ele Ferrannini, Mariaelisa Graff, Cornelia M. van Duijn, Juha Auvinen, David R. Weir, Kay-Tee Kaw, Tarunveer S. Ahluwalia, Olov Rolandsson, Wei Zhao, Paul Elliott, Torben Hansen, Abbas Dehghan, Bram P. Prins, Michiel L. Bots, Alison Pattie, Jun Liu, Gonçalo R. Abecasis, Maria Karaleftheri, Claudia Langenberg, Jan-Håkan Jansson, Marja Vääräsmäki, James S. Pankow, Rebecca S. Fine, Jaana Lindström, Ozren Polasek, Vinicius Tragante, Soren K. Thomsen, Jana K. Rundle, Najaf Amin, Saima Afaq, Jennifer A. Smith, Anne U. Jackson, Eirini Marouli, Weihua Zhang, Tim D. Spector, Paul W. Franks, Serena Sanna, Mark J. Caulfield, Heikki A. Koistinen, Jaspal S. Kooner, Tea Skaaby, Francis S. Collins, Eva Rabing Brix Petersen, Arfan Ikram, Sander W. van der Laan, Johanna Kuusisto, Jette Bork-Jensen, Daniel I. Chasman, Michele K. Evans, Emmanouil Tsafantakis, A. I. Tarasov, Ian J. Deary, Hans Bisgaard, Dennis O. Mook-Kanamori, Helen R. Warren, Kent D. Taylor, Andrew D. Morris, Eleftheria Zeggini, Sharon L.R. Kardia, Emma Ahlqvist, Gert J. de Borst, Torben Jørgensen, Antonella Mulas, Man Li, Betina H. Thuesen, Yuan Shi, Timo A. Lakka, Jie Yao, Tapani Ebeling, Natasha H. J. Ng, Sai Chen, Leena Kinnunen, Antje Körner, Klaus Bønnelykke, Lorraine Southam, Anette P. Gjesing, Ilonca Vaartjes, Heather M. Highland, Göran Hallmans, Anke Tönjes, Markku Laakso, Lenore J. Launer, Josef Coresh, Oscar H. Franco, Yongmei Liu, Beverley Balkau, Leena Moilanen, Karl-Heinz Herzig, James G. Wilson, Jennifer A. Brody, Renée de Mutsert, Alisa K. Manning, Anne E. Justice, Matthias B. Schulze, Sandosh Padmanabhan, Jose C. Florez, Shuang Feng, Heather M. Stringham, Bruce M. Psaty, Erwin P. Bottinger, Hannu Puolijoki, Vilmundur Gudnason, Leif Groop, Nicholas J. Wareham, Karina Meidtner, Andrew P. Morris, Taulant Muka, Benoit Hastoy, Panos Deloukas, Pirjo Komulainen, Ayse Demirkan, Francesco Cucca, Stefan Gustafsson, Eric Boerwinkle, Patrik Rorsman, Mike A. Nalls, Erik Ingelsson, Colin N. A. Palmer, Allan Linneberg, Tiinamaija Tuomi, Dan E. Arking, Steve Franks, Jonathan Marten, Mark Walker, Ruifang Li-Gao, Kai Savonen, Michael Stumvoll, Andreas Fritsche, E-Shyong Tai, Mark O. Goodarzi, Matt J. Neville, Oluf Pedersen, Eero Kajantie, Ching-Ti Liu, Michael Boehnke, Aaron Leong, Patricia B. Munroe, Patricia A. Peyser, Jessica D. Faul, John C. Chambers, John Danesh, Sirkka Keinänen-Kiukaanniemi, Giorgio Pistis, Karen L. Mohlke, Folkert W. Asselbergs, James B. Meigs, Tibor V. Varga, Erica L. Kleinbrink, Andrew T. Hattersley, Nathan A. Bihlmeyer, Harald Grallert, Albert V. Smith, Konstantin Strauch, Jerome I. Rotter, Frits R. Rosendaal
Publikováno v:
SSRN Electronic Journal.
SummaryMetabolic dysregulation in multiple tissues alters glucose homeostasis and influences risk for type 2 diabetes (T2D). To identify pathways and tissues influencing T2D-relevant glycemic traits (fasting glucose [FG], fasting insulin [FI], two-ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785079dbcb50e1abe846740e443e2f2a
https://doi.org/10.2139/ssrn.3469835
https://doi.org/10.2139/ssrn.3469835
Autor:
Laura J. Scott, Neil Robertson, Anders Hamsten, Domenico Palli, Susanne Moebus, Bernhard O. Boehm, Gunnar Sigurðsson, Paul W. Franks, C. N. A. Palmer, Sonali Pechlivanis, Katharine R. Owen, Michael E. Reschen, Sarah Edkins, Jason Carey, Christopher A. O’Callaghan, Norman Klopp, Caroline S. Fox, Petter Storm, N. William Rayner, Johan G. Eriksson, Thomas Illig, Anubha Mahajan, Erik Ingelsson, Allan Linneberg, Andrew R. Wood, Oddgeir L. Holmen, Nicola L. Beer, Mark I. McCarthy, Frank B. Hu, Peter Almgren, Heiner Boeing, Peter Donnelly, Carl Platou, Veikko Salomaa, Karl-Heinz Jöcke, Wen-Hong L. Kao, Lori L. Bonnycastle, Denis Rybin, Benjamin F. Voight, Peter Kraft, Inês Barroso, Claudia Langenberg, Teresa Ferreira, Peter Kovacs, Anne Raimondo, Christian Theil Have, Ulf de Faire, Torben Hansen, Han Chen, James B. Meigs, Timothy M. Frayling, Noël P. Burtt, Gerald Steinbach, Eric Boerwinkle, Michael Stumvoll, Stefan Gustafsson, Lars Lind, Andrew D. Morris, Alena Stančáková, Panagiotis Deloukas, Kari Stefansson, Augustine Kong, Hans A. Kestler, Andrew T. Hattersley, Beverley Balkau, Lorenzo Pasquali, Yingchang Lu, Nicola D. Kerrison, George B. Grant, Eeva Korpi-Hyövälti, Steven Wiltshire, Karl Gertow, Jorge Ferrer, Barbara Thorand, Inga Prokopenko, Matthias Blüher, Yvonne T. van der Schouw, Olga McLeod, Oluf Pedersen, Leena Peltonen, Anil Chalisey, Eleftheria Zeggini, Joseph Trakalo, Eric J.G. Sijbrands, Rainer Rauramaa, Guillaume Charpentier, Satu Männistö, Cordelia Langford, Lewin Eisele, Damiano Baldassarre, Lennart C. Karssen, Rona J. Strawbridge, Ghazala Mirza, Peter S. Chines, Roman Wennauer, Sara M. Willems, Erwin P. Bottinger, Timo Saaristo, Stéphane Cauchi, Ching-Ti Liu, Martijn van de Bunt, Valgerdur Steinthorsdottir, David Altshuler, Hyun Min Kang, Michael Boehnke, Jaakko Tuomilehto, Peter M. Nilsson, Kyle J. Gaulton, Jian'an Luan, Loic Yengo, David Couper, Reedik Mägi, Harald Grallert, Simone Wahl, Juha Saltevo, Phoenix Kwan, Cecilia M. Lindgren, Peter Lichtner, Richard N. Bergman, Andrew Crenshaw, João Fadista, Michael Roden, Annette Peters, Robert A. Scott, Unnur Thorsteinsdottir, James S. Pankow, Yeji Lee, Cornelia M. van Duijn, Samuli Ripatti, Francis S. Collins, Stéphane Lobbens, Niels Grarup, Ruth J. F. Loos, Julia Meyer, Marit E. Jørgensen, Christian Herder, Inger Njølstad, John R. B. Perry, Markus M. Nöthen, Man Li, Martina Müller-Nurasyid, Valeriya Lyssenko, Pierre Fontanillas, Michael D. Linderman, Leena Kinnunen, Jana K. Rundle, Elena Tremoli, Marilyn C. Cornelis, Tanya M. Teslovich, Todd Green, Raimund Erbel, Elisabeth M. van Leeuwen, Bengt Sennblad, Olle Melander, Sirkka Keinänen-Kiukaanniemi, Markku Laakso, Eero Lindholm, Alex S. F. Doney, Anke Tönjes, Maija Hassinen, Thomas W. Mühleisen, Gonçalo R. Abecasis, Nancy L. Pedersen, Thomas Sparsø, Johanna Kuusisto, Dorothée Thuillier, Qi Sun, Ian Dunham, Himanshu Chheda, Adam E. Locke, Philippe Froguel, Nicholas J. Wareham, Bruna Gigante, Jose C. Florez, Mozhgan Dorkhan, Omri Gottesman, Liming Liang, Anna Jonsson, Tiinamaija Tuomi, Leif Groop, Steve E. Humphries, Heikki A. Koistinen, Kristian Hveem, Astradur B. Hreidarsson, Jason Flannick, Torben Jørgensen, Clement Ma, Mattias Frånberg, Ewan Birney, Andrew P. Morris, Timo A. Lakka, Rob M. van Dam, Heather M. Stringham, Christian Gieger, Elodie Eury, Konstantin Strauch, Anna L. Gloyn, Rafn Benediktsson, Andres Metspalu, David J. Hunter, Karen L. Mohlke, Gudmar Thorleifsson, Josée Dupuis, Emmi Tikkanen, Christian Fuchsberger, Evelin Mihailov, Christopher J. Groves, Soren K. Thomsen, Tõnu Esko, Anne U. Jackson, Karin Leander, Douglas M. Ruderfer, Nikolay Oskolkov, Sekar Kathiresan, Robert Sladek, Lu Qi, Jasmina Kravic, Carmen Navarro
Publikováno v:
Nature Genetics, 47, 1415. Nature Publishing Group
Nature Genetics, 47(12), 1415-+. Nature Publishing Group
Nature genetics, 47(12), 1415-+. Nature Publishing Group
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A E, Rayner, N W, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Jørgensen, M E, Hansen, T & DIAGRAM Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature Genetics
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A, William Rayner, N, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Balkau, B, Jørgensen, T & DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature genetics
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Genetics, 47(12), 1415-+. Nature Publishing Group
Nature genetics, 47(12), 1415-+. Nature Publishing Group
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A E, Rayner, N W, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Jørgensen, M E, Hansen, T & DIAGRAM Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature Genetics
Gaulton, K J, Ferreira, T, Lee, Y, Raimondo, A, Mägi, R, Reschen, M E, Mahajan, A, Locke, A, William Rayner, N, Robertson, N, Scott, R A, Prokopenko, I, Scott, L J, Green, T, Sparso, T, Thuillier, D, Yengo, L, Grallert, H, Wahl, S, Frånberg, M, Strawbridge, R J, Kestler, H, Chheda, H, Eisele, L, Gustafsson, S, Steinthorsdottir, V, Thorleifsson, G, Qi, L, Karssen, L C, van Leeuwen, E M, Willems, S M, Li, M, Chen, H, Fuchsberger, C, Kwan, P, Ma, C, Linderman, M, Lu, Y, Thomsen, S K, Rundle, J K, Beer, N L, van de Bunt, M, Chalisey, A, Kang, H M, Voight, B F, Abecasis, G R, Almgren, P, Baldassarre, D, Balkau, B, Jørgensen, T & DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium 2015, ' Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci ', Nature Genetics, vol. 47, no. 12, pp. 1415-1425 . https://doi.org/10.1038/ng.3437
Nature genetics
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
To access publisher's full text version of this article click on the hyperlink at the bottom of the page We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0b5ee13e5230169a934120dd03c1e8
https://dspace.library.uu.nl/handle/1874/332306
https://dspace.library.uu.nl/handle/1874/332306
Autor:
Anna L. Gloyn, Kara Osbak, Jana K. Rundle, Anne Raimondo, Joseph Grimsby, Amy Barrett, Emma L. Edghill, Kirsty J. Wensley, Nicola L. Beer, Kevin Colcough, N. D. Tribble, Martijn van de Bunt, Lucia Valentinova, Anna M. Steele, Sian Ellard
Publikováno v:
Diabetes Care; Vol 35
Diabetes Care
Diabetes Care
OBJECTIVE To demonstrate the importance of using a combined genetic and functional approach to correctly interpret a genetic test for monogenic diabetes. RESEARCH DESIGN AND METHODS We identified three probands with a phenotype consistent with maturi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a9df11952531041afaf036eeebd5c1
Publikováno v:
Cancer research. 68(2)
In addition to the directly mutagenic effects of energy deposition in DNA, ionizing radiation is associated with a variety of untargeted and delayed effects that result in ongoing bone marrow damage. Delayed effects are genotype dependent with CBA/Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f80230eb45293d36984b828c35fe280
https://pubmed.ncbi.nlm.nih.gov/18199539
https://pubmed.ncbi.nlm.nih.gov/18199539