The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy.

Autor: René A J Crans, Jana Janssens, Sofie Daelemans, Elise Wouters, Robrecht Raedt, Debby Van Dam, Peter P De Deyn, Kathleen Van Craenenbroeck, Christophe P Stove

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210567 (2019)

BackgroundIn gene expression studies via RT-qPCR many conclusions are inferred by using reference genes. However, it is generally known that also reference genes could be differentially expressed between various tissue types, experimental conditions

Externí odkaz: https://doaj.org/article/34a0321889814f3f9d9076c54f4ba413

Monoaminergic and Kynurenergic Characterization of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis in Cerebrospinal Fluid and Serum

Autor: Ido P. Kema, Peter Paul De Deyn, Claude van der Ley, Jana Janssens, Martijn van Faassen, Yannick Vermeiren

Publikováno v: Neurochemical Research, 45(5), 1191-1201
Neurochemical Research 45 (2020) 5
Neurochemical research
NEUROCHEMICAL RESEARCH, 45(5), 1191-1201. SPRINGER/PLENUM PUBLISHERS
Neurochemical Research

Exploring the neurochemical continuum between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with respect to monoamines and kynurenines in cerebrospinal fluid (CSF) and serum, may be useful to identify possible new research/the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ec2c877a5a0a14538da3ca9a4ddd79
https://doi.org/10.1007/s11064-020-03002-5

Evaluating the applicability of mouse SINEs as an alternative normalization approach for RT-qPCR in brain tissue of the APP23 model for Alzheimer's disease

Autor: Peter Paul De Deyn, Debby Van Dam, Jana Janssens, Jo Vandesompele, Christophe P. Stove, Kathleen Van Craenenbroeck, Rene A. J. Crans

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
JOURNAL OF NEUROSCIENCE METHODS
Journal of Neuroscience Methods, 320, 128-137. ELSEVIER SCIENCE BV
Journal of neuroscience methods

Background: The choice of appropriate reference genes (RGs) for use in reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been thoroughly investigated, since the inclusion of unstable RGs might cause inaccurate gene expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb86d026c085148f27b4b14ebe6e8a6
https://research.rug.nl/en/publications/6c9b0d4f-d3c2-47ec-88d3-4ec0c367ec9b

Sampling issues of cerebrospinal fluid and plasma monoamines : investigation of the circadian rhythm and rostrocaudal concentration gradient

Autor: Izaak den Daas, Peter Paul De Deyn, Anthony Absalom, Jana Janssens, Sawal Atmosoerodjo, Yannick Vermeiren

Publikováno v: Neurochemistry international
Neurochemistry International, 128, 154-162. PERGAMON-ELSEVIER SCIENCE LTD
Neurochemistry International 128 (2019)
Neurochemistry International, 128, 154-162

Biomarkers for neurodegenerative dementias offer interesting prospects regarding diagnosis and disease monitoring. Monoamines such as dopamine, (nor)adrenaline, serotonin (5-hydroxytryptamine or 5-HT), and their respective metabolites homovanillic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea90eebfe3b992854c5095d322c7deff
https://hdl.handle.net/10067/1595850151162165141

[P4–473]: BIOLOGICAL FLUID MONOAMINE LEVELS TO EXPLORE THE NEUROCHEMICAL CONTINUUM BETWEEN FRONTOTEMPORAL DEMENTIA AND AMYOTROPHIC LATERAL SCLEROSIS

Autor: Jana Janssens, Yannick Vermeiren, Peter Paul De Deyn, Tony Aerts, Debby Van Dam

Publikováno v: Alzheimer's & Dementia. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2153da22a07922b56278bada10457a48
https://doi.org/10.1016/j.jalz.2017.07.634