Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jana Janočková"'
Autor:
Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://doaj.org/article/6487d4fed0064893867020e3dda083eb
Autor:
Youssef Dgachi, Hélène Martin, Rim Malek, Daniel Jun, Jana Janockova, Vendula Sepsova, Ondrej Soukup, Isabel Iriepa, Ignacio Moraleda, Emna Maalej, M. Carmo Carreiras, Bernard Refouvelet, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 163-170 (2019)
In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs
Externí odkaz:
https://doaj.org/article/e3c0e08c463645d08a8cc7dd58a4bda9
Autor:
Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 583-606 (2018)
Alzheimer’s disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist
Externí odkaz:
https://doaj.org/article/f4d7abc278ba4229b488013ba972aa08
Autor:
Jana Janockova, Rafael Dolezal, Eugenie Nepovimova, Tereza Kobrlova, Marketa Benkova, Kamil Kuca, Jan Konecny, Eva Mezeiova, Michaela Melikova, Vendula Hepnarova, Avi Ring, Ondrej Soukup, Jan Korabecny
Publikováno v:
Molecules, Vol 23, Iss 11, p 2926 (2018)
The neuropeptides, orexin A and orexin B (also known as hypocretins), are produced in hypothalamic neurons and belong to ligands for orphan G protein-coupled receptors. Generally, the primary role of orexins is to act as excitatory neurotransmitters
Externí odkaz:
https://doaj.org/article/5d196cdbcad34cc5a090e956de18bdd5
Autor:
Youssef Dgachi, Oscar M. Bautista-Aguilera, Mohamed Benchekroun, Hélène Martin, Alexandre Bonet, Damijan Knez, Justyna Godyń, Barbara Malawska, Stanislav Gobec, Mourad Chioua, Jana Janockova, Ondrej Soukup, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Publikováno v:
Molecules, Vol 21, Iss 5, p 634 (2016)
We report herein the straightforward two-step synthesis and biological assessment of novel racemic benzochromenopyrimidinones as non-hepatotoxic, acetylcholinesterase inhibitors with antioxidative properties. Among them, compound 3Bb displayed a mixe
Externí odkaz:
https://doaj.org/article/275dbed00fe84937878fb5586f6d45ed
Autor:
Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová, Rastislav Jendželovský, Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnatova, Tomáš Kučera, Petr Bzonek, Nikola Novakova, Daniel Jun, Lucie Junova, Jan Korábečný, Kamil Kuča, Mária Kožurková
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3830 (2021)
A series of novel C4-C7-tethered biscoumarin derivatives (12a–e) linked through piperazine moiety was designed, synthesized, and evaluated biological/therapeutic potential. Biscoumarin 12d was found to be the most effective inhibitor of both acetyl
Externí odkaz:
https://doaj.org/article/8c388bb7284d4588979e48d7f965924d
Autor:
Annachiara Gandini, Ana Elisa Gonçalves, Silvia Strocchi, Claudia Albertini, Jana Janočková, Anna Tramarin, Daniela Grifoni, Eleonora Poeta, Ondrej Soukup, Diego Muñoz-Torrero, Barbara Monti, Raimon Sabaté, Manuela Bartolini, Giuseppe Legname, Maria Laura Bolognesi
Publikováno v:
ACS Chemical Neuroscience. 13:3314-3329
Alzheimer's disease (AD), the most common type of dementia, currently represents an extremely challenging and unmet medical need worldwide. Amyloid-β (Aβ) and Tau proteins are prototypical AD hallmarks, as well as validated drug targets. Accumulati
Publikováno v:
Ekológia (Bratislava), Vol 34, Iss 3, Pp 281-292 (2015)
The strictly protected natural area of Sucha Bela Gorge, located in the Slovak Paradise National Park, Slovakia, is exposed to environmental degradation by heavy tourist loads. Although educational and technical measures have been put in place, there
Autor:
Óscar M, Bautista-Aguilera, Stefanie, Hagenow, Alejandra, Palomino-Antolin, Víctor, Farré-Alins, Lhassane, Ismaili, Pierre-Louis, Joffrin, María L, Jimeno, Ondřej, Soukup, Jana, Janočková, Lena, Kalinowsky, Ewgenij, Proschak, Isabel, Iriepa, Ignacio, Moraleda, Johannes S, Schwed, Alejandro, Romero Martínez, Francisco, López-Muñoz, Mourad, Chioua, Javier, Egea, Rona R, Ramsay, José, Marco-Contelles, Holger, Stark
Publikováno v:
Angewandte Chemie (International ed. in English). 56(41)
The therapy of complex neurodegenerative diseases requires the development of multitarget-directed drugs (MTDs). Novel indole derivatives with inhibitory activity towards acetyl/butyrylcholinesterases and monoamine oxidases A/B as well as the histami
Autor:
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2605-2620 (2022)
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the mo
Externí odkaz:
https://doaj.org/article/1b4b604d4ed2463eadfec515d42a5564