Physico-chemical characterization of bilirubin-10-sulfonate and comparison of its acid–base behavior with unconjugated bilirubin

Autor: Adam Čepa, Veronika Dejmková, Ladislav Lešetický, Ivan Jelínek, Stanislav Smrček, Martin Štícha, Jana Jašprová, Marie Urbanová, Iryna Goncharova, Martin Dračínský, Eliška Procházková, Donald J. Ostrow, Libor Vítek

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Unconjugated bilirubin (UCB) is the end-product of heme catabolism in the intravascular compartment. Although beneficial for human health when mildly elevated in the body, when present at greater than a critical threshold concentration, UCB

Externí odkaz: https://doaj.org/article/76e84440156a41a0b3afe937582ade16

Inhibition of Lipid Accumulation in Skeletal Muscle and Liver Cells: A Protective Mechanism of Bilirubin Against Diabetes Mellitus Type 2

Autor: Claudia A. Hana, Eva-Maria Klebermass, Theresa Balber, Markus Mitterhauser, Ruth Quint, Yvonne Hirtl, Antonia Klimpke, Sophie Somloi, Juliana Hutz, Elisabeth Sperr, Paulina Eder, Jana Jašprová, Petra Valášková, Libor Vítek, Elke Heiss, Karl-Heinz Wagner

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Ectopic lipid accumulation in skeletal muscle and liver drives the pathogenesis of diabetes mellitus type 2 (DMT2). Mild hyperbilirubinaemia has been repeatedly suggested to play a role in the prevention of DMT2 and is known for its capacity to shape

Externí odkaz: https://doaj.org/article/b0b61de1ce7240eb9f32b589bdda3d89

Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia

Autor: Dicky Struik, Rick Havinga, Lori W E van der Schoor, Sanne de Wit, Johan W. Jonker, Robert H. Tukey, Libor Vítek, Andrea B. Schreuder, Henkjan J. Verkade, Anna Bertolini, Petra Valášková, Elvira Mennillo, André A. Weber, Shujuan Chen, Jana Jašprová, Vincent W. Bloks, Eva Rettenmeier

Publikováno v: Scientific Reports, 11(1):11107. Nature Publishing Group
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Neonatal hyperbilirubinemia or jaundice is associated with kernicterus, resulting in permanent neurological damage or even death. Conventional phototherapy does not prevent hyperbilirubinemia or eliminate the need for exchange transfusion. Here we in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60cbafbcae8193448363254ae0105a0
https://research.rug.nl/en/publications/9bf99e8f-1982-4c37-93e5-fd86ee8f1e22

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects

Autor: Lucie Muchová, Kateřina Vaňková, Jana Jašprová, Jaroslav Zelenka, Roman Sobotka, Jan Rasl, Tomáš Vomastek, Libor Vítek, Aleš Dvořák, Ivana Marková, Iva Subhanová, Iva Novosádová

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
Oxidative Medicine and Cellular Longevity

Nutritional factors which exhibit antioxidant properties, such as those contained in green plants, may be protective against cancer. Chlorophyll and other tetrapyrrolic compounds which are structurally related to heme and bilirubin (a bile pigment wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::547fbfe379b2edef38337b9f98bdb343
https://doi.org/10.1155/2018/4069167

Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice

Autor: David Biedermann, Lucie Muchová, Kateřina Valentová, Lucie Petrásková, Libor Vítek, Jana Jašprová, Jakub Šuk, Vladimír Křen

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity

Bilirubin is considered to be one of the most potent endogenous antioxidants in humans. Its serum concentrations are predominantly affected by the activity of hepatic bilirubin UDP-glucuronosyl transferase (UGT1A1). Our objective was to analyze the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2360aae0fb695826d62f1c62f6c4d5