Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption.

Autor: Jana Husse, Sophie Charlotte Hintze, Gregor Eichele, Hendrik Lehnert, Henrik Oster

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52983 (2012)

Human and animal studies demonstrate that short sleep or poor sleep quality, e.g. in night shift workers, promote the development of obesity and diabetes. Effects of sleep disruption on glucose homeostasis and liver physiology are well documented. Ho

Externí odkaz: https://doaj.org/article/37f9fab8f9594f58b49e97c6c7034ed3

Dissecting and modeling photic and melanopsin effects to predict sleep disturbances induced by irregular light exposure in mice

Autor: Mio Kobayashi Frisk, Ludivine Robin-Choteau, Jessica W. Tsai, Gregor Eichele, Elisabeth Ruppert, Fanny Fuchs, L. Calvel, Jana Husse, Jeffrey Hubbard, Patrice Bourgin, Paul Franken

Publikováno v: Preoceedings of the National Academy of Sciences of the USA
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 25, pp. e2017364118

Significance Light pervasively affects physiology and behavior, especially the sleep–wake cycle (SWc), which is generated by clock signaling in the suprachiasmatic nuclei (SCN). Light synchronizes this clock and additionally exerts direct (circadia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da6966216985f4d3a7ed9a4eb8dab4ba
https://hdl.handle.net/21.11116/0000-0009-778F-121.11116/0000-0009-7779-A

Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

Autor: Jana Husse, Gabriela Salinas, Johanna L. Barclay, Judit Meyer-Kovac, Anthony H. Tsang, Alexei Leliavski, Thomas Lingner, Lea Ehrhardt, Henrik Oster, Isa Kolbe

Publikováno v: Molecular Metabolism, Vol 6, Iss 6, Pp 512-523 (2017)
Molecular Metabolism

Objective Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8020680862123f1eb61dfb1744bd21a
http://www.sciencedirect.com/science/article/pii/S2212877817301722

Tissue-Specific Dissociation of Diurnal Transcriptome Rhythms During Sleep Restriction in Mice

Autor: Nadine Naujokat, Jana Husse, Judit Meyer-Kovac, Henrik Oster, Johanna L. Barclay, Jana-Thabea Kiehn, Hendrik Lehnert

Publikováno v: Sleep

Study objectives: Shortened or mistimed sleep affects metabolic homeostasis, which may in part be mediated by dysregulation of endogenous circadian clocks. In this study, we assessed the contribution of sleep disruption to metabolic dysregulation by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc59dc0977d9f51b7443a29c1a74f49
https://pubmed.ncbi.nlm.nih.gov/28444394

Zirkadiane Uhren in Gehirn und Peripherie: biologische Funktion und Relevanz für die Klinik

Autor: Jana Husse, Alexei Leliavski, Henrik Oster

Publikováno v: Deutsche Medizinische Wochenschrift

In den meisten Organismen - von Cyanobakterien bis zum Menschen - haben sich genetisch kodierte zirkadiane Uhren entwickelt, die Verhalten und Physiologie an im Tagesverlauf veränderliche Umweltbedingungen adaptieren. Störungen der Uhr, zum Beispie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b94ea0d67520646fd62a4c19ea58ffb
https://doi.org/10.1055/s-0032-1332901