Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jana Hroudová"'
Autor:
Jiri Patocka, Jan Korabecny, Kamil Kuca, Zdenek Fisar, Jana Hroudova, Florian Nachon, Vlastimil Dohnal, Filip Zemek, Veronika Opletalova, Daniel Jun, Eugenie Nepovimova, Ondrej Holas, Kamil Musilek
Publikováno v:
Molecules, Vol 15, Iss 12, Pp 8804-8812 (2010)
A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Its in
Externí odkaz:
https://doaj.org/article/acc47589d8844599b46912943b1405e5
Autor:
Zdeněk Fišar, Jana Hroudová
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 191 (2024)
The progress in understanding the pathogenesis and treatment of Alzheimer’s disease (AD) is based on the recognition of the primary causes of the disease, which can be deduced from the knowledge of risk factors and biomarkers measurable in the earl
Externí odkaz:
https://doaj.org/article/b934321f133d47199f3ca25bf72af8b9
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1208 (2023)
Mitochondrial dysfunction is involved in the pathophysiology of psychiatric and neurodegenerative disorders and can be used as a modulator and/or predictor of treatment responsiveness. Understanding the mitochondrial effects of antidepressants is imp
Externí odkaz:
https://doaj.org/article/e297f50efb2e482d95aa589a19224122
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1564 (2023)
Mitochondrial dysfunction is an important cellular hallmark of aging and neurodegeneration. Platelets are a useful model to study the systemic manifestations of mitochondrial dysfunction. To evaluate the age dependence of mitochondrial parameters, ci
Externí odkaz:
https://doaj.org/article/3d2fb26ba6394849b0a29661dda1730f
Alzheimer's disease (AD) is associated with mitochondrial dysfunction and disturbances in neurotransmitter systems. Depression is a common comorbidity of AD, and the disruption of monoaminergic neurotransmission may be involved in the pathophysiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc76b624100284ee5ea5cbb3f83f335a
https://doi.org/10.21203/rs.3.rs-2402088/v1
https://doi.org/10.21203/rs.3.rs-2402088/v1
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13824
This determination of the mitochondrial effect of pharmacologically different antidepressants (agomelatine, ketamine and vortioxetine) was evaluated and quantified in vitro in pig brain-isolated mitochondria. We measured the activity of mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae53cf4dd8e2527fb2dc7eed59568aa
https://pubmed.ncbi.nlm.nih.gov/36430306
https://pubmed.ncbi.nlm.nih.gov/36430306
Autor:
Lucie Vinklářová, Ondřej Benek, Jiří Raboch, Monika Schmidt, Lukas Hroch, Kamil Musilek, Zdeněk Fišar, Jana Hroudová
Publikováno v:
Toxicology Letters. 339:12-19
Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a multifunctional mitochondr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5f6dd87b9c04545b4d79ce2dee5269
https://doi.org/10.1016/j.toxlet.2020.12.012
https://doi.org/10.1016/j.toxlet.2020.12.012
Publikováno v:
Molecular Neurobiology. 58:1102-1113
The trends of novel AD therapeutics are focused on multitarget-directed ligands (MTDLs), which combine cholinesterase inhibition with additional biological properties such as antioxidant properties to positively affect neuronal energy metabolism as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7ce33348b04aa0444da27a6fde517b
https://doi.org/10.1007/s12035-020-02172-1
https://doi.org/10.1007/s12035-020-02172-1
Autor:
Zdeněk, Fišar, Jana, Hroudová
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2277
Platelet mitochondria can be used in the study of mitochondrial dysfunction in various complex diseases and can help in finding biological markers for diagnosing the disease, monitoring its course and the effects of treatment. The aim of this chapter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed7b777d7b4e2bfb93ca610b93d2a7b2
https://pubmed.ncbi.nlm.nih.gov/34080156
https://pubmed.ncbi.nlm.nih.gov/34080156
Autor:
Hana Hansikova, Eva Kitzlerová, Jiří Zeman, Jana Hroudová, Roman Jirák, Jiří Raboch, Zdeněk Fišar, Martina Zvěřová, Laszlo Wenchich, Jana Křížová
Publikováno v:
Mitochondrion. 48:67-77
We analyzed activities of complex I, II, III, and IV, and citrate synthase (CS) in patients with major depressive disorder (MDD) or Alzheimer's disease (AD) presenting with or without depression. Associations of these parameters with disease or disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32507f0a2d7e81b42db45c23cb8d20f3
https://doi.org/10.1016/j.mito.2019.07.013
https://doi.org/10.1016/j.mito.2019.07.013